A nomogram to predict sarcopenia in middle-aged and older women: a nationally representative survey in China

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 5, 2025

Sarcopenia is a disease characterized by losing muscle mass, strength, and function with age. Studies have shown that sarcopenia generally higher in women than men. Therefore, this study used the 2015 China Health Retirement Longitudinal Study (CHARLS) data to explore further risk factors associated middle-aged older Chinese women. In study, from CHARLS database were analyzed, comprising 7,805 eligible participants. Participants categorized into either group (n = 2,160) or non-sarcopenia 5,645) based on presence absence of sarcopenia. Through utilization logistic regression analysis, multiple identified. Additionally, predictive value these was assessed applying receiver operating characteristic (ROC) curve analysis. Subsequently, visual nomogram prediction model developed incorporating identified R4.1.2 software. Age, area, education, marriage, waist circumference, stroke, body pain, depression, region may be closely related addition, integrated sarcopenia-related variables comprehensive index, ROC analysis results showed AUC composite index 0.738. This found age, waist, physical region. constructs help clinicians better screen potential female patients

Language: Английский

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The role of diet, obesity and body composition in epithelial ovarian cancer development and progression: Mechanisms and therapeutic implications

Gynecologic Oncology Reports, Journal Year: 2025, Volume and Issue: 58, P. 101718 - 101718

Published: March 16, 2025

Epithelial ovarian cancer (EOC) ranks among the deadliest cancers, with over half of newly diagnosed patients presenting metastatic disease, highlighting need for early detection strategies and a deeper understanding biologic factors that impact EOC progression treatment response. This paper aims to synthesize current literature on association between diet, obesity, body composition prognosis, drawing translational, molecular, clinical studies identify gaps in research inform preventative improve outcomes patients. The diet prognosis suggests role several dietary interventions prevention development progression, including increased intake animal-based proteins (specifically dairy products), fiber-rich foods, cruciferous vegetables, polyunsaturated fats, ongoing trials examine variations intermittent fasting fasting-mimicking diets However, nutritional survival therapeutic response remains largely understudied, low quality evidence this area limits ability form comprehensive recommendations. Therefore, study calls future recommendations ultimate goals improving patient life. Additionally, obesity high-fat may contribute through chronic low-grade inflammation, consideration adiposity intervention parameters should be investigated research.

Language: Английский

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The effect of oral nutritional supplementation combined with probiotics on the liver function and intestinal microflora in lung cancer chemotherapy patients through the gut-liver axis

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 24, 2025

The role of gut microbiota in cancer treatment research is receiving increasing attention. This study aims to evaluate the oral nutritional supplementation combined with probiotics on liver function and intestinal microflora lung chemotherapy patients. An evaluation was conducted involving 113 patients cancer, who were given routine hospitalization diet nutrition supplement (ONS). intervention group received probiotic supplementation, while control placebo. It lasted for 21 days. primary endpoint changes microflora. Secondary endpoints included immune status, blood lipids. Compared group, there differences serum levels ALT, AST, endotoxin amount (P < 0.05). However, no significant found nutrition, immune, lipids status. ONS could improve status We speculate that this may be due supplementing regulating gut-liver axis.

Language: Английский

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Pre-Operative Malnutrition in Patients with Ovarian Cancer: What Are the Clinical Implications? Results of a Prospective Study

Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 622 - 622

Published: Jan. 31, 2024

Background: Malnutrition was associated with worse survival outcomes, impaired quality of life, and deteriorated performance status across various cancer types. We aimed to identify risk factors for malnutrition in patients epithelial ovarian (EOC) impact on survival. Methods: In our prospective observational monocentric study, we included the primary recurrent EOC, tubal or peritoneal conducted. assessed serum laboratory parameters, body mass index, nutritional screening score (NRS-2002), bio-electrical impedance analysis. Results: recruited a total 152 patients. Patients > 65 years-old, ascites >500 mL, platinum-resistant EOC showed statistically significant increased when evaluated using NRS-2002 (p-values= 0.014, 0.001, 0.007, respectively). < 3 an independent predictive factor complete tumor resectability (p = 0.009). The ≥ had median overall (OS) seven months (95% CI 0–24 months), as compared 3, where OS forty-six 0.001). A phase angle (PhAα) ≤ 4.5 strongest predictor OS. Conclusions: found be incomplete cytoreduction prognostic poor Preoperative assessment is effective tool identification high-risk groups characterized by clinical outcome.

Language: Английский

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Factors Associated with Nutritional Risk Assessment in Critically Ill Patients Using the Malnutrition Universal Screening Tool (MUST)

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(5), P. 1236 - 1236

Published: Feb. 21, 2024

Background: Malnutrition is an underdiagnosed condition that negatively affects the clinical outcomes of patients, being associated with increased risk adverse events, hospital stay, and higher mortality. Therefore, nutritional assessment a required necessary process in patient care. The objective this study was to identify factors by applying Universal Screening Tool (MUST) scale population critically ill patients. Methods: This observational, analytical, retrospective study. Sociodemographic, clinical, hematological, biochemical variables their relationship mortality were analyzed. Results: Of 630 leading cause admission pathologies circulatory respiratory system (50%); 28.4% at high risk; 11.6% risk, hemoglobin, plasma urea nitrogen. Conclusions: presence gastrointestinal symptoms type support received during hospitalization could increase likelihood presenting medium/high while polycythemia reduced probability. An associative model found determine adequate specificity diagnostic validity index.

Language: Английский

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Breaking Down Cachexia: A Narrative Review on the Prevalence of Cachexia in Cancer Patients and Its Associated Risk Factors

Nutrition and Cancer, Journal Year: 2024, Volume and Issue: 76(5), P. 404 - 418

Published: March 28, 2024

Cachexia is an irreversible condition that involves a significant loss of body weight, muscle mass, and adipose tissue. It complex variety metabolic, hormonal, immune-related factors, with the precise mechanisms not yet fully understood. In this review, prevalence cachexia in different types cancer as well potential risk factors was evaluated from literature retrieved databases such ScienceDirect, PubMed Scopus. Potential here include tumor-related location, stage cancer, patient-related age, gender, comorbidities. Several findings were observed where more prevalent male patients than females, higher incidences weight poorer outcomes. This may be due to compositions between gender. Additionally, at later stages, which brought about by late-stage diagnosis certain cancers. The anatomical location cancers pancreas stomach play factor their high cachexia. These are sites synthesis digestive enzymes hormones regulating appetite. issue faced could affect recovery. However, it poorly understood, limit therapeutic options. Hence, understanding disease perspectives (clinical pre-clinical), bridging those further improve our comprehension consequently

Language: Английский

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Low serum creatinine levels are associated with major post-operative complications in patients undergoing surgery with gynecologic oncologists

International Journal of Gynecological Cancer, Journal Year: 2024, Volume and Issue: 34(7), P. 1060 - 1069

Published: April 16, 2024

Serum creatinine is a byproduct of muscle metabolism, and low postulated to be associated with diminished mass. This study examined the association between pre-operative serum post-operative outcomes. retrospective cohort utilized 2014-2021 National Surgical Quality Improvement Program identify patients undergoing surgery gynecologic oncologists. Patients missing creatinine, end-stage renal disease, sepsis, septic shock, dialysis, or pregnancy were excluded. Pre-operative was categorized into markedly (≤0.44 mg/dL), mildly (0.45-0.64 normal (0.65-0.84 four categories elevated levels (0.85-1.04, 1.05-1.24, 1.25-1.44, ≥1.45 mg/dL). Outcomes included major (≥Grade 3) 30-day complications, any wound, cardiovascular pulmonary, renal, infectious, thromboembolic complications. Also readmissions, reoperations, mortality. Logistic regressions assessed stratification by albumin sensitivity analysis propensity score matching. Among 84 786 patients, 0.8% had low, 19.6% 50.2% creatinine; remainder creatinine. As decreased, risks complications increased in dose-dependent manner on univariable multivariable analyses. A total 9.6% (n=63) experienced second mg/dL (9.9%, n=141). On models, both higher odds (OR 1.715, 95% CI 1.299 2.264 OR 1.093, 1.001 1.193) infections 1.575, 1.118 2.218 1.165, 1.048 1.296) versus normal. Markedly similar ORs further pulmonary 2.301, 1.300 4.071), readmissions 1.403, 1.045 1.884), mortality 2.718, 1.050 7.031). After stratification, associations persisted for Propensity-weighted analyses demonstrated congruent findings. Low are oncology manner. can offer useful information risk surgical counseling, peri-operative management.

Language: Английский

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Glucagon-like peptide-1 (GLP-1) receptor agonists for weight management: A review for the gynecologic oncologist

Gynecologic Oncology, Journal Year: 2024, Volume and Issue: 190, P. 1 - 10

Published: Aug. 7, 2024

Language: Английский

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Prognostic value of the fibrinogen albumin ratio index (FARI) in nasopharyngeal carcinoma patients undergoing radiotherapy

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 23, 2023

Abstract There is mounting evidence that malnutrition and systemic inflammation status are involved in the prognosis of various cancers. In this study, we aimed to evaluate prognostic value pretreatment fibrinogen-albumin ratio index (FARI) nasopharyngeal carcinoma (NPC) patients receiving definite radiotherapy. NPC who received radiotherapy between January 2013 December 2019 were included. A receiver operating characteristic (ROC) curve was used determine optimal cutoff value. The clinicopathological characteristics compared via Chi-square test. Survival curves analyzed by Kaplan‒Meier method. factors evaluated univariate multivariate analyses Cox hazards regression analysis. total 225 enrolled, median follow-up time 48.5 months. High FARI correlated with worse ECOG score (p = 0.003), higher EBV-DNA titer 0.047), more advanced clinical stage < 0.001). multivariable analysis, independently predicted OS (HR 2.399, 95% CI 1.294–4.450, P 0.001), PFS 2.085, 1.200–3.625, 0.009), DMFS 2.527, 1.288–4.958, current findings suggest a high an independent predictor OS, undergoing

Language: Английский

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Role of Incretins in Muscle Functionality, Metabolism, and Body Composition in Breast Cancer: A Metabolic Approach to Understanding This Pathology

Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 280 - 280

Published: Jan. 25, 2024

A poorly studied issue in women with breast cancer is the role of incretins (GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1)) quantity quality muscle mass lean obese individuals. The current report aims to analyze patterns association incretin functionality body composition compared healthy (mammography BI-RADS I or II) elucidate whether GIP can be used estimate risk, conjunction overweight obesity, for cancer. We designed a case–control study diagnosis confirmed by biopsy different clinical stages (CS; n = 87) mastography II within last year (n 69). were grouped according index (BMI): (<25 kg/m2BS), (≥25–<30 (≥30 kg/m2BS). found that levels over 18 pg/mL associated risk OR 36.5 4.16, entire sample), particularly 8.8 6.5), coincidentally low indexes, showed an between cancer, defects, loss functionality.

Language: Английский

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