HPA flexibility and FKBP5: promising physiological targets for conservation DOI Creative Commons
Cédric Zimmer, Blanca Jimeno, Lynn B. Martin

et al.

Published: Nov. 30, 2023

Hypothalamic-pituitary-adrenal axis (HPA) flexibility is an emerging concept recognizing that individuals will cope best with stressors probably be those using their hormones in the most adaptive way. The HPA considers glucocorticoids as molecules convey information about environment from brain to body so organismal phenotype comes complement prevailing conditions. In this context, FKBP5 protein appears set extent which circulating glucocorticoid concentrations can vary within and across stressors. Thus, expression, it causes, seem represent individual’s ability regulate its orchestrate responses As expression also easily measured blood, could a worthy target of conservation-oriented research attention. We first review known likely roles wildlife. then describe putative genetic, environmental, epigenetic causes variation among- within-individuals. Finally, we hypothesize how should affect fitness hence population viability response human-induced rapid environmental changes, particularly urbanization.

Language: Английский

Early-life environmental effects on birds: epigenetics and microbiome as mechanisms underlying long-lasting phenotypic changes DOI Creative Commons
Suvi Ruuskanen

Journal of Experimental Biology, Journal Year: 2024, Volume and Issue: 227(Suppl_1)

Published: March 7, 2024

ABSTRACT Although the long-lasting effects of variation in early-life environment have been well documented across organisms, underlying causal mechanisms are only recently starting to be unraveled. Yet understanding can help us predict how organisms will respond changing environments. Birds offer a great system which study developmental plasticity and its owing production large external eggs trajectories, combined with long tradition applied, physiological, ecological evolutionary research. Epigenetic changes (such as DNA methylation) suggested key mechanism mediating taxa. More recently, gut microbiome identified another potential mediator plasticity. As first step whether these contribute birds, this Review summarizes (both prenatal postnatal) influence epigenetic markers microbiome. The literature shows both biotic resources social environment) abiotic (thermal various anthropogenic stressors) factors modify yet data concerning many other environmental limited. links modifications lasting phenotypic still scarce, but hypothalamic–pituitary–adrenal axis one putative pathway. This identifies several knowledge gaps, including on long-term effects, stability molecular changes, lack diversity systems studied, provides directions for future

Language: Английский

Citations

6
Forecasting the future? Differential allocation of maternal hormones under different social contexts in the blue tit Cyanistes caeruleus DOI Creative Commons
Alejandro García Antón, Wendt Müller, Jorge García‐Campa

et al.

Royal Society Open Science, Journal Year: 2025, Volume and Issue: 12(4)

Published: April 1, 2025

Sociability, i.e. the tendency to interact with other individuals, varies significantly within populations, some individuals being consistently more sociable than others. Variation may be maintained because balance between costs (e.g. increase in aggressive disputes, infection risk) and benefits information exchange, cooperation) of sociability environmental context. At proximate level, apart from genes, mothers transfer non-genetic compounds their offspring that can influence development social skills. In this context, they adjust offspring’s match environment will experience after birth, for example, via prenatal hormones. To test this, we experimentally manipulated density as perceived by blue tit females before egg laying. We subsequently measured yolk testosterone concentrations interactions among family members post-hatching. Females were exposed a simulated high transferred less eggs control females. Network average degree (i.e. number brood) was not affected treatment, but broods lower showed higher network degree. This suggests experiencing an (but increased resource competition) deposit produce are probably sociable.

Language: Английский

Citations

0
HPA flexibility and FKBP5 : promising physiological targets for conservation DOI Open Access
Cédric Zimmer, Blanca Jimeno, Lynn B. Martin

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 379(1898)

Published: Feb. 5, 2024

Hypothalamic–pituitary–adrenal axis (HPA) flexibility is an emerging concept recognizing that individuals will cope best with stressors probably be those using their hormones in the most adaptive way. The HPA considers glucocorticoids as molecules convey information about environment from brain to body so organismal phenotype comes complement prevailing conditions. In this context, FKBP5 protein appears set extent which circulating glucocorticoid concentrations can vary within and across stressors. Thus, expression, it causes, seem represent individual's ability regulate its orchestrate responses As expression also easily measured blood, could a worthy target of conservation-oriented research attention. We first review known likely roles wildlife. then describe putative genetic, environmental epigenetic causes variation among individuals. Finally, we hypothesize how should affect fitness hence population viability response human-induced rapid changes, particularly urbanization. This article part theme issue ‘Endocrine variation: conceptual approaches recent developments’.

Language: Английский

Citations

1
Sedentary life accelerates epigenetic ageing in King penguins DOI Creative Commons
Robin Cristofari, Leyla R. Davis, Gaël Bardon

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Introductory paragraph Advances in medicine and food security have contributed to an increase human lifespan 1 . Yet, the associated rise sedentary behaviour obesity 2,3 already threatens these gains 4 Indeed, a growing body of evidence supports central role nutrient sensing energy management pathways regulating ageing rate healthspan 5,6 , but diversity lifestyles challenges our ability identify genetic epigenetic drivers this age acceleration. Here, we examine how transition wild King penguins zoo husbandry can closely mimic shift Western lifestyle humans, shed light on evolutionarily conserved changes responses conditions. We show that, just like modern zoo-housed experience extended lifespan, comes at cost accelerated throughout life. This is with differential methylation key growth maintenance including mTOR PI3K/Akt networks, as well specific lipid-rich diet adaptation heart-function. Our results demonstrate deeply link between availability one hand, acceleration other. Such evolutionary may turn help us improve risk detection and, ultimately, therapeutics for lifestyle-induced humans 7

Language: Английский

Citations

1
From maternal glucocorticoid and thyroid hormones to epigenetic regulation of offspring gene expression: An experimental study in a wild bird species DOI Creative Commons
Mikaela Hukkanen, Bin‐Yan Hsu, Nina Cossin‐Sevrin

et al.

Evolutionary Applications, Journal Year: 2023, Volume and Issue: 16(10), P. 1753 - 1769

Published: Oct. 1, 2023

Offspring phenotype at birth is determined by its genotype and the prenatal environment including exposure to maternal hormones. Variation in both glucocorticoids thyroid hormones can affect offspring phenotype, but underlying molecular mechanisms, especially those contributing long-lasting effects, remain unclear. Epigenetic changes (such as DNA methylation) have been postulated mediators of effects early-life environment. In this study, we elevated glucocorticoid on handling stress response (breath rate) well methylation gene expression receptor (GR) hormone (THR) great tits (Parus major). Eggs were injected before incubation onset with corticosterone (the main avian glucocorticoid) and/or (thyroxine triiodothyronine) simulate variation deposition. Breath rate during GR THR evaluated 14 days after hatching. Methylation status genes was analyzed from longitudinal blood cells sampled 7 hatching, following autumn. Elevated level significantly increased breath handling, indicating an enhanced metabolic response. Prenatal manipulation had CpG-site-specific putative promoter region, while it did not expression. negatively associated earlier hatching date chick size. or exhibit any significant relationship hormonal treatments examined covariates, suggesting that TH signaling may be more robust due crucial role development. This study provides some support hypothesis influence via epigenetic alterations, yet their possible adaptive optimizing prevailing conditions, context-dependency, interplay needs further research.

Language: Английский

Citations

3
From maternal glucocorticoid and thyroid hormones to epigenetic regulation of gene expression: an experimental study in a wild bird species DOI Creative Commons
Mikaela Hukkanen, Bin‐Yan Hsu, Nina Cossin‐Sevrin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 7, 2023

Offspring phenotype at birth is determined by its genotype and the prenatal environment including exposure to maternal hormones. Variation in both glucocorticoids thyroid hormones can affect offspring phenotype. However, underlying molecular mechanisms shaping phenotype, especially those contributing long-lasting effects, remain unclear. Epigenetic changes (such as DNA methylation) have been postulated mediators of effects early-life environment. In this study, we elevated glucocorticoid on handling stress response (breath rate), methylation gene expression receptor (GCR) hormone (THR) great tit ( Parus major ). Eggs were injected before incubation onset with corticosterone (main avian glucocorticoid) and/or (thyroxine triiodothyronine) simulate variation deposition. Breath rate during GCR THR evaluated 14 days after hatching. Methylation status genes analyzed from longitudinal blood samples taken 7 hatching, well following autumn. Elevated level significantly increased breath handling, indicating enhanced metabolism. Prenatal manipulation had CpG-site-specific putative promoter region, while it did not expression. was negatively associated earlier hatching date chick size. or exhibit any significant relationship hormonal treatments examined covariates, suggesting that TH signaling may be more robust due crucial role development. This study supports view influence metabolism via epigenetic alterations, yet their possible adaptive optimizing prevailing conditions, context-dependency, interplay needs further research.

Language: Английский

Citations

2
Glucocorticoid receptor expression in blood, but not across brain regions, reveals long-term effects of early life adversity in zebra finches DOI Creative Commons
Blanca Jimeno, Yoran H. Gerritsma, G. Mulder

et al.

Physiology & Behavior, Journal Year: 2023, Volume and Issue: 271, P. 114310 - 114310

Published: Aug. 3, 2023

Early-life environment can affect organisms for life on many levels. The glucocorticoid receptor (GR) gene has a pivotal role mediating organismal physiological and behavioral responses to environmental change, is sensitive early-life conditions epigenetic programming. Longitudinal studies require non-lethal sampling of peripheral tissues (e.g. blood), but this approach dependent the extent which GR expression in covaries with central tissues. To test long-term effects early adversity across brain tissues, we manipulated developmental captive zebra finches (n = 45), rearing them either benign or harsh through manipulation parental foraging costs. We measured relative mRNA blood five regions adulthood: hippocampus, hypothalamus, amygdala, ventral striatum, nidopallium caudolaterale (analogous mammalian prefrontal cortex), using qPCR. further tested whether was modulated by natal brood size (which affected growth), age at sampling, sex. correlations among varied widely magnitude direction, ranging from -0.27 +0.80, indicating that our understanding associated phenotypes needs be region specific rather than organism wide. A more consistent pattern increased blood, striatum hippocampus; independent other Developmental treatment did not any directly, adult females found positive correlation between nestling mass expression. Thus, as reflected growth females, also one tissue, ubiquitous regions. These results point sex-dependent constraints during development, shaping only. Further study required investigate these tissue-dependent generally reflect adversity. This, together investigating consequences levels individual performance coping abilities, will fundamental towards mechanisms impacts life, quantified sampling.

Language: Английский

Citations

2
Maternally derived avian corticosterone affects offspring genome‐wide DNA methylation in a passerine species DOI Creative Commons
Anna Miltiadous, Damien L. Callahan, Antoine M. Dujon

et al.

Molecular Ecology, Journal Year: 2024, Volume and Issue: 33(6)

Published: Jan. 30, 2024

Avian embryos develop in an egg composition which reflects both maternal condition and the recent environment of their mother. In birds, yolk corticosterone (CORT) influences development by impacting pre- postnatal growth, as well nestling stress responses development. One possible mechanism through CORT may affect offspring is via changes to DNA methylation. We sought investigate this, for first time quantifying impact manipulations on non-invasively manipulated plasma concentrations egg-laying female zebra finches (Taeniopygia castanotis) with acute dose administered around ovulation collected eggs. then assessed methylation resulting embryonic tissue associated vitelline membrane blood vessels, during early (5 days after lay), using two established methods - liquid chromatography-mass spectrometry (LC-MS) methylation-sensitive amplification fragment length polymorphism (MS-AFLP). LC-MS analysis showed that global was lower from CORT-treated mothers, compared control embryos. contrast, vessel eggs mothers increases, samples. There a higher proportion second clutches, clutches. Locus-specific analyses MS-AFLP did not reveal treatment effect. Our results indicate elevation impacts patterns offspring. This could provide mechanistic understanding how mother's experience can her offspring's phenotype.

Language: Английский

Citations

0
Lasting benefits of embryonic eavesdropping on parent-parent communication DOI Creative Commons
Francisco Ruiz‐Raya, Alberto Velando

Science Advances, Journal Year: 2024, Volume and Issue: 10(35)

Published: Aug. 30, 2024

Developing embryos have traditionally been viewed as passive agents in the evolution of family conflicts, with maternal substances within uterus or eggs main factors modulating later expression offspring solicitation behaviors. Yet, parent-offspring conflict theory predicts that might also rely on alternative cues to adjust demand response prenatal parental capacity for resource provisioning. Here, we show how embryonic experience vocalizations carried out by parents during nest-relief displays at incubation adaptively shapes avian development, providing lasting benefits offspring. Genetic siblings prenatally exposed different levels parent-parent communication showed differences epigenetic patterns, adrenocortical responsiveness, and food behavior. The correspondence between acoustic context positively influenced nutritional status growth rate reared communicative parents. Offspring can thus retain strong control over their own development gathering information about generosity.

Language: Английский

Citations

0
HPA flexibility and FKBP5: promising physiological targets for conservation DOI Creative Commons
Cédric Zimmer, Blanca Jimeno, Lynn B. Martin

et al.

Published: Nov. 30, 2023

Hypothalamic-pituitary-adrenal axis (HPA) flexibility is an emerging concept recognizing that individuals will cope best with stressors probably be those using their hormones in the most adaptive way. The HPA considers glucocorticoids as molecules convey information about environment from brain to body so organismal phenotype comes complement prevailing conditions. In this context, FKBP5 protein appears set extent which circulating glucocorticoid concentrations can vary within and across stressors. Thus, expression, it causes, seem represent individual’s ability regulate its orchestrate responses As expression also easily measured blood, could a worthy target of conservation-oriented research attention. We first review known likely roles wildlife. then describe putative genetic, environmental, epigenetic causes variation among- within-individuals. Finally, we hypothesize how should affect fitness hence population viability response human-induced rapid environmental changes, particularly urbanization.

Language: Английский

Citations

0