Impact of stress on excitatory and inhibitory markers of adolescent cognitive critical period plasticity

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 153, P. 105378 - 105378

Published: Aug. 27, 2023

Adolescence is a time of significant neurocognitive development. Prolonged maturation prefrontal cortex (PFC) through adolescence has been found to support improvements in executive function. Changes excitatory and inhibitory mechanisms critical period plasticity have be present the PFC adolescence, suggesting that environment may greater effect on development during this time. Stress one factor known affect neurodevelopment increasing risk for psychopathology. However, less about how stress experienced could adolescent-specific cognitive outcomes. In review, we synthesize findings from human animal literatures looking at experience cognition frontal neural activity. Studies indicate enhancing effects acute excitation within specific contexts, while chronic generally dampens processes impairs cognition. We propose model plasticity, thus potentially altering neurodevelopmental trajectories lead

Language: Английский

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Dorsal bed nucleus of the stria terminalis GABA neurons are necessary for chronic unpredictable stress-induced depressive behaviors in adolescent male mice

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 182, P. 347 - 357

Published: Jan. 18, 2025

Language: Английский

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Repeated stress gradually impairs auditory processing and perception

PLoS Biology, Journal Year: 2025, Volume and Issue: 23(2), P. e3003012 - e3003012

Published: Feb. 11, 2025

Repetitive stress, a common feature of modern life, is major risk factor for psychiatric and sensory disorders. Despite the prevalence perceptual abnormalities in these disorders, little known about how repetitive stress affects processing perception. Here, we combine mice, longitudinal measurement cortical activity, auditory-guided behaviors to test if sound perception neutral sounds adults are modulated by stress. We found that alters processing, increasing spontaneous activity while dampening sound-evoked responses pyramidal PV cells heightening SST cells. These alterations auditory culminated shifts, particularly reduction loudness Additionally, our work reveals impact on evolves gradually as stressor persists over time, emphasizing dynamic evolving nature this mechanism. Our findings provide insight into possible mechanism which behavior, challenging idea primarily modulates emotionally charged stimuli.

Language: Английский

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Early-Life Stress Caused by Maternal Deprivation Impacts Dendritic Morphology of Adult Male Mouse Neocortical Interneurons

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1909 - 1909

Published: Feb. 23, 2025

A substantial body of research suggests that early-life stress (ELS) is associated with neuropathology in adulthood. Maternal deprivation (MD) a commonly utilised model mice for the study specific neurological diseases. The appropriate growth dendrites essential optimal functioning nervous system. However, impact ELS on interneuron dendritic morphology remains unclear. To ascertain whether induces alterations GABAergic inhibitory interneurons layers II/III medial entorhinal cortex (mEC), somatosensory (SSC), motor (MC), and CA1 region hippocampus (Hp), 9-day-old male GAD-67-EGFP transgenic were subjected to 24 h MD. At postnatal day 60 (P60), animals sacrificed, their brains morphological analyses. results indicated MD affected interneurons. mean length segments examined cortical areas, except MC, significantly decreased, whereas number primary was unaffected. Furthermore, density GAD67-EGFP-positive decreased mEC Hp, but not MC. induction through developmental time window when significant changes occur rendered developing cells particularly susceptible stress, resulting reduction surviving at adult stage.

Language: Английский

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Brain mechanisms underlying the inhibitory control of thought

Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Language: Английский

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Long term effects of peripubertal stress on the thalamic reticular nucleus of female and male mice

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 200, P. 106642 - 106642

Published: Aug. 22, 2024

Adverse experiences during infancy and adolescence have an important enduring effect on the brain are predisposing factors for mental disorders, particularly major depression. This impact is notable in regions with protracted development, such as prefrontal cortex. The inhibitory neurons of this cortical region altered by peripubertal stress (PPS), female mice. In study we explored whether circuits thalamus impacted PPS male diencephalic structure, cortex, also completes its development postnatal life affected adverse experiences. long-term changes induced were exclusively found adult We that increases depressive-like behavior induces parvalbumin-expressing (PV+) cells thalamic reticular nucleus (TRN). observed reductions volume TRN, together those parameters related to structures/molecules regulate plasticity connectivity PV+ cells: perineuronal nets, matricellular structures surrounding neurons, polysialylated form neural cell adhesion molecule (PSA-NCAM). expression GluN1, but not GluN2C, NMDA receptor subunit was augmented TRN after PPS. An increase fluorescence intensity puncta synaptic output lateral posterior nucleus. These results demonstrate thalamus, vulnerable effects aversive early life, females. vulnerability probably might contribute psychiatric disorders.

Language: Английский

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MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 31, 2023

Chronic stress exerts profound negative effects on cognitive and emotional behaviours is a major risk factor for the development of neuropsychiatric disorders. However, molecular links between chronic its deleterious neuronal synaptic function remain elusive. Here, using combination in vitro vivo approaches, we demonstrate that upregulation miR-186-5p triggered by may be key mediator such changes, leading to dysfunction. Our results show expression levels are increased both in prefrontal cortex (PFC) mice exposed cortical neurons chronically dexamethasone. Additionally, viral overexpression PFC naïve induces anxiety- depressive-like behaviours. The through prolonged glucocorticoid receptor activation differentially affects glutamatergic GABAergic transmission, causing an imbalance excitation/inhibition altered network activity. At synapses, observed reduction AMPAR along with switch their subunit composition, whereas transmission was strengthened. These changes could rescued inhibitor. Overall, our establish novel link activation, induced stress, amenable therapeutic intervention.

Language: Английский

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Bimatoprost Ophthalmic Solution (BOS) 0.3 mg w/v for 1 Open Trial of Long-term Preventive Therapy of Migraine in 3 patients with Pathophysiologic Shift from Brain to Eye

Journal of Neuroscience and Neurological Disorders, Journal Year: 2023, Volume and Issue: 7(2), P. 134 - 154

Published: Nov. 9, 2023

Known since antiquity, migraine is a complex primary disorder, an episodic painful Autonomic Nervous System (ANS) storm, generally following the stress/post-stress phase. Despite exhaustive study of neuropeptides, neurochemicals, molecules, neurogenetics, neuroimaging along with animal and human experiments over last 50 years, scientific basis remains unknown. Straddling eight decades from Cortical Spreading Depression (CSD) to Calcitonin-Gene Related Peptide (CGRP) its antagonists, exponentially increasing data have failed create gestalt synthesis. This article lays cohesive robust fundamental principles for comprehension management migraine. The continuum between non-congestive Primary Open-Angle Glaucoma (POAG), Normal Tension (NTG), or Low-Tension (LTG) advancing. case sustained remission attacks (> 75%) 3 years - 5 ocular hypotensive topical Bimatoprost Ophthalmic Solution (BOS) 0.3% in N-of-1 trial patients refractory presented. A cause-effect-adaptive process underlies ANS-stress/post-stress-linked biology Vasopressin-serotonin-norepinephrine ‘homeostatic-adaptive system’ Lowers Intraocular Pressure (IOP), while enhancing anti-stress, antinociception, vasomotor, behaviour control functions, thereby selectively decreasing algogenic neural traffic ophthalmic division trigeminal nerve (V1), and, raising threshold develop Striking headache-aborting feature vomiting also likely linked several hundred-fold increase arginine-vasopressin secretion. Eye-cover tests self-ocular digital displacement are essential studying visual aura. Real-time physical Scintillating Scotoma (SS) floating ‘stars’ reported. spontaneous onset offset, self-limited duration attacks, as well female preponderance, age/menopause decline prevalence, elucidated. implants long-term effects, including bimatoprost, future management. Controlled trials required establish migraine-preventive effect revolutionary advance neuroscience.

Language: Английский

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Activation of somatostatin interneurons in the medial amygdala reverses long-term aggressive behavior associated to early-life stress in male mice

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 19, 2024

Abstract Early postnatal development is a critical period for the configuration of neural networks that support emotional and socio-affective behaviors. In this sense, children raised in stressful environments are at high risk developing maladaptive behaviors immediately or later life, including anti-social aggressive However, neurobiological bases such phenomena remain poorly understood. Here we showed that, long-term, maternal separation with early weaning (MSEW) decreased density somatostatin (SST) interneurons basolateral amygdala (BLA) females males, while their activity was only reduced medial (MeA) males. Interestingly, hypoactivity resulted increased aggressivity low social interest. To test whether manipulation MeA SST+ sufficient to reverse these negative behavioral outcomes, chemogenetically expressed hM3Dq receptors MSEW adult We found activation ameliorated interaction aggression traits. Altogether, our results highlight role neurons regulation interest point loss as plausible etiological mechanism linking life stress life.

Language: Английский

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MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Language: Английский

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