PLoS ONE,
Journal Year:
2010,
Volume and Issue:
5(11), P. e13950 - e13950
Published: Nov. 15, 2010
Background
Late
Onset
Alzheimer's
disease
(LOAD)
is
the
leading
cause
of
dementia.
Recent
large
genome-wide
association
studies
(GWAS)
identified
first
strongly
supported
LOAD
susceptibility
genes
since
discovery
involvement
APOE
in
early
1990s.
We
have
now
exploited
these
GWAS
datasets
to
uncover
key
pathophysiological
processes.
Methodology
applied
a
recently
developed
tool
for
mining
data
biologically
meaningful
information
dataset.
The
principal
findings
were
then
tested
an
independent
Principal
Findings
found
significant
overrepresentation
signals
pathways
related
cholesterol
metabolism
and
immune
response
both
two
largest
LOAD.
Significance
Processes
innate
previously
been
implicated
by
pathological
epidemiological
disease,
but
it
has
unclear
whether
those
reflected
primary
aetiological
events
or
consequences
process.
Our
evidence
from
demonstrates
that
processes
are
aetiologically
relevant,
suggests
they
may
be
suitable
targets
novel
existing
therapeutic
approaches.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2016,
Volume and Issue:
2016(1)
Published: Jan. 1, 2016
There
is
significant
evidence
that,
in
living
systems,
free
radicals
and
other
reactive
oxygen
nitrogen
species
play
a
double
role,
because
they
can
cause
oxidative
damage
tissue
dysfunction
serve
as
molecular
signals
activating
stress
responses
that
are
beneficial
to
the
organism.
Mitochondria
have
been
thought
both
major
role
provide
protection
against
excessive
through
several
mechanisms,
including
stimulation
of
opening
permeability
transition
pores.
Until
recently,
functional
significance
ROS
sources
different
from
mitochondria
has
received
lesser
attention.
However,
most
recent
data,
besides
confirming
mitochondrial
protection,
show
interplay
between
cellular
sources,
so
activation
one
lead
sources.
Thus,
it
currently
accepted
various
conditions
all
contribution
processes
oxidatively
tissues
assure
their
survival,
mechanisms
such
autophagy
apoptosis.
Dialogues in Clinical Neuroscience,
Journal Year:
2009,
Volume and Issue:
11(2), P. 111 - 128
Published: June 30, 2009
More
than
25
million
people
in
the
world
today
are
affected
by
dementia,
most
suffering
from
Alzheimer's
disease.
In
both
developed
and
developing
nations,
disease
has
had
tremendous
impact
on
individuals,
caregivers,
society.
The
etiological
factors,
other
older
age
genetic
susceptibility,
remain
to
be
determined.
Nevertheless,
increasing
evidence
strongly
points
potential
risk
roles
of
vascular
factors
disorders
(eg,
cigarette
smoking,
midlife
high
blood
pressure
obesity,
diabetes,
cerebrovascular
lesions)
possible
beneficial
psychosocial
education,
active
social
engagement,
physical
exercise,
mentally
stimulating
activity)
pathogenetic
process
clinical
manifestation
dementing
disorders.
long-term
multidomain
interventions
toward
optimal
control
multiple
maintenance
socially
integrated
lifestyles
activities
expected
reduce
or
postpone
onset
including
Brain,
Journal Year:
2008,
Volume and Issue:
131(3), P. 681 - 689
Published: Jan. 18, 2008
To
be
diagnostically
useful,
structural
MRI
must
reliably
distinguish
Alzheimer's
disease
(AD)
from
normal
aging
in
individual
scans.
Recent
advances
statistical
learning
theory
have
led
to
the
application
of
support
vector
machines
for
detection
a
variety
states.
The
aims
this
study
were
assess
how
successfully
assigned
diagnoses
and
determine
whether
data-sets
combined
multiple
scanners
different
centres
could
used
obtain
effective
classification
We
linear
classify
grey
matter
segment
T1-weighted
MR
scans
pathologically
proven
AD
patients
cognitively
elderly
individuals
obtained
two
with
scanning
equipment.
Because
clinical
diagnosis
mild
is
difficult
we
also
tested
ability
differentiate
control
without
post-mortem
confirmation.
Finally
sought
use
these
methods
between
suffering
those
frontotemporal
lobar
degeneration.
Up
96%
verified
correctly
classified
using
whole
brain
images.
Data
achieving
comparable
results
separate
analyses.
Importantly,
data
one
centre
train
machine
accurately
ageing
another
subjects
scanner
Patients
mild,
clinically
probable
age/sex
matched
controls
separated
89%
cases
which
compatible
published
rates
best
centres.
This
method
confirmed
either
or
degeneration
their
respective
group.
Our
leads
three
conclusions:
Firstly,
healthy
subjects.
Secondly,
they
perform
well
differential
forms
dementia.
Thirdly,
robust
can
generalized
across
suggests
an
important
role
computer
based
diagnostic
image
analysis
practice.
