Proceedings of the National Academy of Sciences,
Journal Year:
2013,
Volume and Issue:
110(19)
Published: April 25, 2013
Significance
It
has
been
proposed
that
differential
physical
interactions
of
apolipoprotein
E
(apoE)
isoforms
with
soluble
amyloid-β
(Aβ)
in
brain
fluids
influence
the
metabolism
Aβ,
providing
a
major
mechanism
to
account
for
how
APOE
influences
Alzheimer’s
disease
risk.
The
current
study
challenges
this
proposal
and
clearly
shows
lipoproteins
containing
apoE
are
unlikely
play
significant
role
Aβ
by
binding
directly
physiological
such
as
cerebrospinal
fluid
or
interstitial
fluid.
Our
vitro
vivo
results
suggest
competing
same
clearance
pathways
within
brain.
Alzheimer s & Dementia,
Journal Year:
2016,
Volume and Issue:
12(3), P. 292 - 323
Published: March 1, 2016
During
the
past
decade,
a
conceptual
shift
occurred
in
field
of
Alzheimer's
disease
(AD)
considering
as
continuum.
Thanks
to
evolving
biomarker
research
and
substantial
discoveries,
it
is
now
possible
identify
even
at
preclinical
stage
before
occurrence
first
clinical
symptoms.
This
AD
has
become
major
focus
postulates
that
early
intervention
may
offer
best
chance
therapeutic
success.
To
date,
very
little
evidence
established
on
this
"silent"
disease.
A
clarification
needed
about
definitions
lexicon,
limits,
natural
history,
markers
progression,
ethical
consequence
detecting
asymptomatic
stage.
article
aimed
addressing
all
different
issues
by
providing
for
each
them
an
updated
review
literature
evidence,
with
practical
recommendations.
Molecular Neurodegeneration,
Journal Year:
2011,
Volume and Issue:
6(1), P. 85 - 85
Published: Jan. 1, 2011
The
hippocampus,
a
brain
area
critical
for
learning
and
memory,
is
especially
vulnerable
to
damage
at
early
stages
of
Alzheimer's
disease
(AD).
Emerging
evidence
has
indicated
that
altered
neurogenesis
in
the
adult
hippocampus
represents
an
event
course
AD.
Although
causal
links
have
not
been
established,
variety
key
molecules
involved
AD
pathogenesis
shown
impact
new
neuron
generation,
either
positively
or
negatively.
From
functional
point
view,
hippocampal
plays
important
role
structural
plasticity
network
maintenance.
Therefore,
dysfunctional
resulting
from
subtle
manifestations
may
turn
exacerbate
neuronal
vulnerability
contribute
memory
impairment,
whereas
enhanced
be
compensatory
response
represent
endogenous
repair
mechanism.
Here
we
review
recent
findings
on
alterations
associated
with
AD,
discuss
potential
neurogenesis-based
diagnostics
therapeutic
strategies
