Rheumatology in the digital health era: status quo and quo vadis?

Nature Reviews Rheumatology, Journal Year: 2024, Volume and Issue: 20(12), P. 747 - 759

Published: Oct. 31, 2024

Language: Английский

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An immersive virtual reality exergame as a patient education approach in fibromyalgia: Pilot study

Digital Health, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 1, 2025

Background Immersive Virtual Reality (VR) has been applied in pain management for various conditions, but its use fibromyalgia (FM) remains underexplored. While physical activity plays a role treating FM, patients’ low tolerance often limits effectiveness. After reviewing the literature on VR and games we designed novel exergame to assist FM patients performing activity, evaluate feasibility. Materials Methods This pilot study involved three female subjects with four healthy volunteers. The main outcomes included qualitative assessments of exertion, levels, psychological states experienced during session, also device comfort. Results Improvements perceived exertion intensity were observed session comparison pre-exergame along reduction depression, stress anxiety levels while using immersive system. Most participants increase relaxation positive emotions exergame. Only one participant was not able complete all due musculoskeletal exacerbation; nevertheless, this patient reported an improvement motivation enjoyment gameplay. Many expressed greater perform exercises environment compared traditional training methods. Conclusion proposed is feasible system that might reduce anxiety, boosting both subjects. A calibration protocol required tailor each user's abilities.

Language: Английский

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Chronic pain, fibromyalgia, and long COVID

Exploration of Musculoskeletal Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Chronic pain is a common problem in rheumatology. A distinction made between nociceptive and nociplastic pain. Nociceptive is, for example, mechanistically explained by persistent inflammation. Neuropathic caused nerve damage of various possible causes. In contrast, not due to tissue or lesion the somatosensory nervous system—at least with currently available techniques. Nociplastic based on an altered perception through modulation stimulus processing. The concept central sensitization, together other neurobiological psychosocial mechanisms, considered be best explanation such conditions. syndrome fibromyalgia (FM), plays major role rheumatology—both terms differential diagnosis because management inflammatory rheumatic diseases can more difficult simultaneous presence FM. During coronavirus pandemic, syndromes similarities FM were described following COVID-19 infection. There growing scientific controversy as whether so-called long COVID (LCS) separate entity just variant

Language: Английский

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Study protocol for a prospective, randomized controlled confirmatory clinical investigation to evaluate the safety and efficacy of a multidisciplinary digital therapeutics in patients with patellofemoral pain syndrome

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Background: Patellofemoral pain is a prevalent knee condition affecting up to 40% of individuals, especially females aged teens 50s. Standard treatments, including exercise therapy, often yield insufficient long-term results, partly due low compliance and psychological factors like depression catastrophizing pain. A digital therapeutics ‘MORA Cure PFP’which combine structured progressive cognitive behavioral therapy via an app, offers solution overcome the limitations conventional treatment for patellofemoral patients. Methods: To evaluate safety efficacy MORA PFP, two-arm controlled trial will enroll 216 patients diagnosed with randomly assigned in 1:1 ratio control groups. The group use while perform self-guided exercises using educational materials. This aims determine if shows greater reduction usual intensity scores at 8 weeks compared group. Additional assessments include worst pain, function, depression, levels. Discussion: Key design elements clinical trial, such as selection, inclusion/exclusion criteria, number patients, primary endpoint, were designed consideration not only medical perspectives but also regulatory aspects software device, device approval health technology assessment. Trial registration: ClinicalTrials.gov., NCT06260865, registered 15th February 2024 (https://clinicaltrials.gov/study/NCT06260865)

Language: Английский

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The impact of exercise intensity on depression in fibromyalgia: a randomized controlled trial

Frontiers in Psychology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 27, 2024

Background Fibromyalgia (FM) is characterized by widespread chronic pain. Although pain the main symptom, approximately 90% of patients have depression. This study aimed to analyze effects Resistance Training (RT) with low and high intensity on depression in FM. Methods Thirty-eight women FM 31 healthy were allocated low-intensity, high-intensity, preferred-intensity, control groups. The underwent 8 weeks supervised RT, two sessions per week 1 h. low-intensity resistance training group (LIRT) performed sets 12 maximum repetitions. high-intensity (HIRT) four six repetitions, preferred (PI) three sets, eight according patient’s tolerance. did not perform any type exercise. Depression was assessed using Beck inventory before start intervention, after 4 weeks. Results higher levels than without disease. After weeks, there a difference depressive symptoms between HIRT LIRT ( p = 0.048), PI 0.048). Conclusion Prescribing RT or significantly reduce however, analyses groups indicated that more effective training. prescription exercise could vary among low, high, intensity, following tolerance for Clinical trial registration https://ensaiosclinicos.gov.br/rg/RBR-74pcmw , RBR-74pcmw.

Language: Английский

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Self-guided digital acceptance and commitment therapy as a treatment option for fibromyalgia

The Lancet, Journal Year: 2024, Volume and Issue: 404(10450), P. 315 - 317

Published: July 1, 2024

Language: Английский

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Generative AI-based knowledge graphs for the illustration and development of mHealth self-management content

Frontiers in Digital Health, Journal Year: 2024, Volume and Issue: 6

Published: Oct. 7, 2024

Background Digital therapeutics (DTx) in the form of mobile health (mHealth) self-management programs have demonstrated effectiveness reducing disease activity across various diseases, including fibromyalgia and arthritis. However, content online varies widely, making them difficult to compare. Aim This study aims employ generative artificial intelligence (AI)-based knowledge graphs network analysis categorize structure mHealth at example a program. Methods A multimodal program targeting post-viral fibromyalgia-like syndromes was developed. In addition general content, customized address specific features digital personas identified through hierarchical agglomerative clustering applied cohort 202 patients with chronic musculoskeletal pain undergoing assessment. Text files consisting 22,150 words divided into 24 modules were used as input data. Two AI web applications, ChatGPT-4 (OpenAI) Infranodus (Nodus Labs), create perform text analysis, 3D visualization. sentiment 129 patient feedback entries performed. Results The ChatGPT-generated graph model provided simple visual overview five primary edges: “Mental challenges”, “Stress its impact”, “Immune system function”, “Long COVID fibromyalgia” “Pain management therapeutic approaches”. visualization more complex graph, term “pain” appearing central edge, closely connecting “sleep”, “body”, “stress”. Topical cluster categories such “chronic management”, “sleep hygiene”, “immune “cognitive therapy”, “healthy eating”, “emotional development”, “fibromyalgia causes”, “deep relaxation”. Gap highlighted missing links, between “negative behavior” “systemic inflammation”. Retro-engineering showed significant conceptual similarities original analysis. Sentiment free comments revealed that most relevant topics addressed by program, exception social contacts. Conclusion Generative tools for can effectively illustrate DTx content. Knowledge are valuable increasing transparency programs, developing new frameworks, incorporating loops.

Language: Английский

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Digital Health Technologies for Cardiometabolic Disease and Diabetes

Journal of the American College of Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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Behavioural therapy app for fibromyalgia

Nature Reviews Rheumatology, Journal Year: 2024, Volume and Issue: 20(9), P. 528 - 528

Published: Aug. 8, 2024

Language: Английский

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