Metabolic Dysfunction-Associated Steatotic Liver Disease and the Cardiovascular System

Trends in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Reporting discrepancy of alcohol intake affecting estimated prevalence of MetALD and ALD

˜The œLancet. Gastroenterology & hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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The Burden of Non-Malignant Metabolic Dysfunction-Associated Steatotic Liver Disease in the Western Pacific Region: A Systematic Analysis from 1990 to 2021

Published: Jan. 1, 2025

Background: The burden of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing, yet there little regional understanding in the Western Pacific. This study aims mainly to report latest MASLD and trends Pacific region for period 1990-2021.

Language: Английский

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From Dysbiosis to Hepatic Inflammation: A Narrative Review on the Diet-Microbiota-Liver Axis in Steatotic Liver Disease

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 241 - 241

Published: Jan. 23, 2025

The gut microbiota has emerged as a critical player in metabolic and liver health, with its influence extending to the pathogenesis progression of steatotic diseases. This review delves into gut-liver axis, dynamic communication network linking microbiome through metabolic, immunological, inflammatory pathways. Dysbiosis, characterized by altered microbial composition, contributes significantly development hepatic steatosis, inflammation, fibrosis via mechanisms such barrier dysfunction, metabolite production, systemic inflammation. Dietary patterns, including Mediterranean diet, are highlighted for their role modulating microbiota, improving axis integrity, attenuating injury. Additionally, emerging microbiota-based interventions, fecal transplantation bacteriophage therapy, show promise therapeutic strategies disease. However, challenges population heterogeneity, methodological variability, knowledge gaps hinder translational application current findings. Addressing these barriers standardized approaches integrative research will pave way microbiota-targeted therapies mitigate global burden

Language: Английский

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Association of prebiotic/probiotic intake with MASLD: evidence from NHANES and randomized controlled trials in the context of prediction, prevention, and a personalized medicine framework

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

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Metabolic dysfunction associated steatotic liver and kidney stones: what is going on?

Current Opinion in Nephrology & Hypertension, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Metabolic dysfunction associated steatotic liver disease (MASLD) is increasing throughout the world, affecting nearly one in three individuals. Kidney stone disease, which also increasing, with MASLD. Common risk factors for both, including obesity, diabetes, dyslipidemia, hypertension, and metabolic syndrome, are likely drivers of this association. We present here a review associations possible interconnections between these two common processes. Epidemiological studies discordant regarding impact sex on association MASLD incident risk. The nature kidney stones rarely taken into account.A favorable milieu uric acid formation may be created by lower urine pH resulting from defective ammonium production insulin resistance, MASLD.Endogenous oxalate synthesis, major factor calcium stones, increased via decline activity enzymes involved detoxification glyoxylate, immediate precursor oxalate. driving remain to elucidated. Potential mechanisms identified underlying include an increase both stones.

Language: Английский

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Association of high-sensitivity C-reactive protein with hepatic fibrosis in patients with metabolic dysfunction-associated steatotic liver disease

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 10, 2025

Objective This study aimed to investigate the association between high-sensitivity C-reactive protein (hsCRP) levels and hepatic fibrosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) assess its predictive efficacy. Methods The included 1,477 participants from United States 1,531 China diagnosed MASLD. Liver stiffness measurement (LSM) controlled attenuation parameter (CAP) were assessed by vibration-controlled transient elastography (VCTE) evaluate presence degree of steatosis. relationship hsCRP MASLD was examined using multivariable-adjusted restricted cubic spline (RCS) models. Additionally, subgroup analyses conducted potential heterogeneity among different characteristic subgroups. Results results demonstrated a significant correlation elevated an increased risk fibrosis, advanced cirrhosis US cohort (OR 2.22, 1.69, 2.85, respectively; all P <0.05). Chinese consistent those cohort, there positive 2.53, 3.85, 3.78, respectively, <0.001). RCS analysis revealed non-linear disparate inflection point values observed across cohorts (approximately 9 mg/L 4 cohort). impact on varied subgroups distinct characteristics. Conclusion present MASLD, notable dose-response relationships differences.

Language: Английский

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Diagnostic Uptake of Targeted Sequencing in Adults With Steatotic Liver Disease and a Suspected Genetic Contribution

Liver International, Journal Year: 2025, Volume and Issue: 45(3)

Published: Feb. 13, 2025

ABSTRACT Background and Aims In patients with steatotic liver diseases (SLD), genetic factors may account for severe involvement despite mild or absence of triggering a strong family history. Aim this study was to examine the diagnostic uptake targeted sequencing (TS), covering both coding non‐coding regions, broad panel 82 lipid metabolism genes in unexplained SLD. Methods We enrolled 49 adult SLD suspected contribution. Genetic variants were detected through customised TS panel, whereas contribution common variation individual susceptibility captured by polygenic risk score (SLD‐PRS). Results A diagnosis rare Mendelian disorder established 11 (22%), independently age Rare possibly contributing clinical phenotype additional 29 (59%). Increased SLD‐PRS values 17 (35%), enabling an increase 24%, especially those without history ( p = 0.03). allowed refinement management 23 (47%) patients. Conclusions The 22% 59% possible selected Evaluation variants, as SLD‐PRS, yields complementary information increasing overall utility examination.

Language: Английский

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The trend in incidence of non-alcoholic fatty liver disease and its impact on cirrhosis and liver cancer: An analysis from Global Burden of Disease 2021

Public Health, Journal Year: 2025, Volume and Issue: 242, P. 79 - 86

Published: March 3, 2025

Language: Английский

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Weight-adjusted waist circumference index with hepatic steatosis and fibrosis in adult females: a cross-sectional, nationally representative study (NHANES 2017–2020)

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 5, 2025

Obesity is detrimental to liver health. Weight-adjusted waist circumference (WWI) a new indicator of obesity that superior body mass index (BMI) and (WC) in predicting obesity. There are limited studies on the relationship between Metabolic Associated Fatty Liver Disease (MASLD) WWI. Therefore, this study aimed investigate association WWI, Controlled Attenuation Parameters (CAP), Stiffness Measurement (LSM), with special attention gender differences. This cross-sectional included participants from 2017 2020 National Health Nutrition Examination Survey (NHANES). The used multiple linear regression models, smoothed curves, threshold effects analyses describe relationships variables. Multiple were examine associations four indicators CAP LSM. Subject work characteristics (ROC) curves assess predictive value WWI other traditional for hepatic steatosis fibrosis, power was assessed by area under curve (AUC). involved 6713 participants, including 3072 men (46%) 3641 women (54%). results showed among female higher associated (OR = 1.71, 95% CI: 1.43, 2.04; P < 0.0001) fibrosis 2.11, 1.58, 2.84; 0.0001). Smoothed fitting versus statistically significant positive correlation male both participants. same non-linear found LSM, no difference males females. also good predictor compared more pronounced (AUC 0.8224). Whereas comparison wBMI better 0.7751). Based study, significantly risk women, suggesting potential as screening tool. Due design, causality cannot be inferred. Longitudinal needed validate our findings.

Language: Английский

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