The multifaceted function of FoxO1 in pancreatic β-cell dysfunction and insulin resistance: Therapeutic potential for type 2 diabetes

Life Sciences, Journal Year: 2025, Volume and Issue: 364, P. 123384 - 123384

Published: Jan. 10, 2025

Language: Английский

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Surveillance and Evaluation of Vitamin D Nutrition and its Health Impact in Chinese Older Adults

Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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High-Density Lipoprotein in Patients with Diabetic Kidney Disease: Friend or Foe?

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1683 - 1683

Published: Feb. 16, 2025

High-density lipoprotein (HDL) exhibits multiple metabolic protective functions, such as facilitating cellular cholesterol efflux, antioxidant, anti-inflammatory, anti-apoptotic and anti-thrombotic properties, showing antidiabetic renoprotective potential. Diabetic kidney disease (DKD) is considered to be associated with high-density (HDL-C). The hyperglycemic environment, non-enzymatic glycosylation, carbamylation, oxidative stress systemic inflammation can cause changes in the quantity quality of HDL, resulting reduced HDL levels abnormal function. Dysfunctional also have a negative impact on pancreatic β cells cells, leading progression DKD. Based these findings, new HDL-related DKD risk predictors gradually been proposed. Interventions aiming improve function, infusion recombinant (rHDL) or lipid-poor apolipoprotein A-I (apoA-I), significantly glycemic control show renal effects. However, recent studies revealed U-shaped relationship between HDL-C DKD, loss properties high may related composition deposition dysfunctional particles that exacerbate damage. Further research needed fully elucidate complex role Given important health, developing HDL-based therapies augment rather than simply increasing its level, critical step managing development

Language: Английский

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A Systematic Review of Oral Health Outcomes following Smoking Cessation in Type 2 Diabetes: Clinical and Research Implications

Journal of Dentistry, Journal Year: 2025, Volume and Issue: unknown, P. 105665 - 105665

Published: March 1, 2025

This systematic review analyzes the effects of smoking cessation on oral health outcomes in individuals with type 2 diabetes. The followed PRISMA guidelines, and protocol was registered PROSPERO (CRD42024604271). Risk bias assessed using Joanna Briggs Institute's critical appraisal tools. PubMed, Scopus, Web Science were searched November 7, 2024, alongside references from highly cited journals conference proceedings. No language or date restrictions applied. Inclusion criteria human clinical studies (randomized controlled trials, cohort, case-control, cross-sectional studies) involving patients diabetes, stratified by status (former, current, never smokers), assessing (e.g., periodontal disease, caries). Studies without detailed data excluded. search retrieved 549 studies, which 4 (N=926 participants) met inclusion criteria. These examined relation to periodontitis progression response therapy. Overall, improving this population appears limited. However, methodological limitations identified, may have been underpowered for subgroup. Evidence impact diabetes remains inconclusive, as large prospective specifically designed purpose are lacking. While benefits general population, its remain unclear. Further research is needed elucidate A multidisciplinary approach managing diabetic essential, where dentists not only address but also support healthy behaviors, including cessation, improve overall diabetes-related complications.

Language: Английский

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Rodent Models of Diabetic Neuropathy, Role of Calcium Homeostasis in Pain and KB-R7943 as a Potential Therapeutic

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2094 - 2094

Published: Feb. 27, 2025

Diabetic neuropathy (DN) is characterized by nerve damage as a consequence of diabetes mellitus. Diabetes causes high blood glucose and triglyceride levels, which destroy the vessels over time trigger DN. Peripheral most common type DN, encompasses broad range symptoms. One fourth patients with suffer from neuropathic pain, decreases their quality life puts them at risk for emotional disturbances depression. Finding an adequate therapy essential element in cure painful DN (PDN). Since pathophysiology this disease still needs to be elucidated, has led development various vivo diabetic models. Animal models not only provide insights into but also are significant drivers treatment assessment improvement. In review, we present major features commonly used chemically diet-induced PDN rodents progress date, utilized better understanding mechanism finding novel therapeutics. Considering role Ca2+ homeostasis review our recent research data on Na+/Ca2+ exchanger blocker KB-R7943, potential pain reliever rodent model

Language: Английский

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Exploring the therapeutic potential of propolis in managing diabetes: a preclinical study

Journal of Traditional Chinese Medical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Use of a Miniaturized Near-Infrared Spectroscopy Device for Type 2 Diabetes Mellitus Screening: Pooled Analysis of the Pilot ANODE01 and ANODE02 Studies

Journal of Diabetes Science and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Current diabetes screening methods are complex, inefficient, and inconvenient, requiring resource-intensive blood sampling. With the increasing prevalence of underdiagnosed type 2 mellitus (T2DM) worldwide, particularly in low-resource settings underserved populations, affordable sustainable mass-screening tools crucial. The accuracy safety miniaturized near-infrared (NIR), full-spectrum spectroscopy Glyconics-DS System detecting T2DM risk status was assessed by pooling data from two independent pilot studies: ANODE01 ANODE02. Rapid NIR assessments glycated nail keratin 60 repeated spectral readings fingernails individuals with or without focused on dichotomized (glycated hemoglobin [HbA1c] <6.5%) based chemometric prediction models, clinical specificity/sensitivity, true/false positive outcomes. An HbA1c point-of-care assay served as an internal control. Over 12 000 were collected a female-dominant (58.5%), mostly non-smoking (80.0%), diverse cohort 200 participants (n = 100 with/n T2D). selected chemometrics model diagnostic cut-off 6.5% showed specificity 92.9% (95% confidence interval [CI] 88.5-97.4) sensitivity 34.2% CI 23.4-45.1), 71.5% concordance. Chemometric predictions consistent reproducible no relevant impact anthropometric variables, concomitant conditions/medications, smoking status, number assessments/nail hand dominance assessment. No adverse events suspected de novo T2D cases reported. This pooled analysis studies demonstrates feasibility high rapid assessment risk, potential for screening, early detection, management across health care settings.

Language: Английский

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Therapeutic effects of composite probiotics derived from fermented camel milk on metabolic dysregulation and intestinal barrier integrity in type 2 diabetes rats

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

In the Kazakh community of Xinjiang, China, fermented camel milk has been traditionally used to manage diabetes. This study evaluates effects composite probiotics derived from (CPCM) on metabolic disturbances in a rat model Type 2 diabetes (T2DM). T2DM was induced Wistar rats using streptozotocin. Experimental groups included diabetic control, Metformin, and low- high-dose CPCM. Measurements over 6 weeks body weight (BW), fasting blood glucose (FBG), oral tolerance test (OGTT), glycated hemoglobin (HbA1c), C-peptide (CP), lipid profiles, inflammatory markers, fecal short-chain fatty acids (SCFAs), tight junction protein expression colonic tissues. High-dose CPCM significantly increased BW by 22.2% (p < 0.05) reduced FBG 6.5 mmol/L 0.001). The OGTT AUC decreased 40.1% 0.001), HbA1c levels fell 22.9% 0.01). CP rose 21.8% 0.05). Lipid profiles improved: TC 40.0%, TG 17.1%, LDL-C 30.4% (all p Fecal SCFAs, including acetate (75.4%, methyl (18.9%, 0.05), butyrate (289.9%, increased, with total SCFAs rising 89.7% Inflammatory markers IL-1β (12.7%, 0.01), TNF-α (16.7%, IL-6 (17.3%, 0.01) were reduced. Tight (ZO-1, occludin, claudin-1) mucin (MUC2) tissues treatment also serum bile 24.9%, while hepatic 114.0% 37.8% lowered DAO, D-lactate, LPS mRNA TGR5 CYP7A1 liver, FXR colon, markedly elevated Histological examinations revealed pancreatic inflammation steatosis, restored structure. improved dysregulation model, reducing levels, enhancing intestinal barrier function, increasing insulin secretion. These findings highlight therapeutic potential management probiotics' role health.

Language: Английский

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Association between neutrophil-to-lymphocyte ratio and left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 10, 2025

Diabetes has become a global pandemic, posing sustained threat to human health, primarily due its associated complications. Left ventricular diastolic dysfunction (LVDD) is prevalent cardiac complication among patients with diabetes. Since most are asymptomatic and lack relevant biomarkers, LVDD not attracted significant attention from clinicians. The neutrophil-to-lymphocyte ratio (NLR) widely studied inflammation biomarker that been suggested be linked various medical conditions, including diseases. However, association type 2 diabetes mellitus (T2DM) explored. To clarify the relationship between NLR We conducted cross-sectional study using records 855 diagnosed T2DM who were admitted Endocrinology department at Wuhan Union Hospital. According ASE/EACVI 2016 recommendations, these categorized into two groups based on sonographic parameters: normal left function (the non-LVDD group) group). values calculated divided three different levels. Statistical analysis was evaluate correlation levels prevalence of LVDD. hospitalized in our 47.8% (409/855). mean value group significantly higher compared [1.60 (1.24-2.05) vs 1.85 (1.44-2.31), P<0.001]. 35.51% (76/214), 49.27% (203/412), 56.77% (130/229), respectively. Unjustified logistic showed positively (P <0.001). Compared low level NLR, unadjusted odds ratios (OR) medium high 1.764 (1.255-2.478, P=0.001) 2.384 (1.626-3.497, P<0.001), respectively for trend Our findings suggest potential indicator assisting clinicians identifying T2DM. Patients elevated may greater risk developing than those lower levels, which require interventions prevent progressing heart failure.

Language: Английский

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Identification of a pancreatic stellate cell gene signature and lncRNA interactions associated with type 2 diabetes progression

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 13, 2025

Background Type 2 diabetes (T2D) has become a significant global health threat, yet its precise causes and mechanisms remain unclear. This study aims to identify gene expression patterns specific T2D pancreatic islet cells explore the potential role of stellate (PSCs) in progression through regulatory networks involving lncRNA-mRNA interactions. Methods In this study, we screened for upregulated genes samples using bulk sequencing (bulkseq) datasets mapped these profiles onto three single-cell RNA (scRNAseq) datasets. The identified T2D-specific features were further validated an additional scRNAseq dataset, T1D bulkseq dataset. To investigate networks, analyzed interactions within peripheral blood mononuclear cell (PBMC) data. Results Our analysis panel—COL1A2, VCAN, SULF1—that was consistently samples. Expression panel strongly associated with activation (PSCs), suggesting unique signature characterized by COL1A2 hi /VCAN /SULF1 PSCs. exclusive not observed 1 (T1D) samples, indicating distinct activated PSCs progression. Furthermore, six long non-coding RNAs (lncRNAs) that potentially interact These lncRNAs network, they may modulate immune responses reshape microenvironment T2D. Discussion findings highlight immune-regulatory suggest PSC-related could serve as novel therapeutic targets treatment. research provides insights into modulator progression, paving way innovative treatment strategies.

Language: Английский

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