Medicine,
Journal Year:
2020,
Volume and Issue:
99(35), P. e22035 - e22035
Published: Aug. 26, 2020
Imbalances
in
the
gut
microbiota
mediate
progression
of
neurodegenerative
diseases
such
as
Parkinson's
disease
(PD).
Fecal
transplantation
(FMT)
is
currently
being
explored
a
potential
therapy
for
PD.
The
objective
this
study
was
to
assess
efficacy
and
safety
FMT
on
Fifteen
PD
patients
were
included,
10
them
received
via
colonoscopy
(colonic
group)
5
nasal-jejunal
tube
(nasointestinal
group).
score
PSQI,
HAMD,
HAMA,
PDQ-39,
NMSQ
UPDRS-III
significantly
decreased
after
treatment
(all
P
<
.05).
Colonic
group
showed
significant
improvement
longer
maintenance
compared
with
nasointestinal
(P
=
.002).
Two
achieved
self-satisfying
outcomes
that
last
more
than
24
months.
However,
had
no
therapeutic
effect,
although
slightly
reduced.
There
satisfied
3
Among
15
patients,
there
cases
adverse
events
(AEs),
including
diarrhea
(2
cases),
abdominal
pain
cases)
flatulence
(1
case).
These
AEs
mild
self-limiting.
We
conclude
can
relieve
motor
non-motor
symptoms
acceptable
Compared
FMT,
colonic
seems
better
preferable.
Frontiers in Microbiology,
Journal Year:
2021,
Volume and Issue:
12
Published: June 23, 2021
The
novel
virus
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
has
caused
a
pandemic
of
disease
2019
(COVID-19).
Across
the
globe,
subset
patients
who
sustain
an
SARS-CoV-2
infection
are
developing
wide
range
persistent
symptoms
that
do
not
resolve
over
course
many
months.
These
being
given
diagnosis
Long
COVID
or
Post-acute
sequelae
COVID-19
(PASC).
It
is
likely
individual
with
PASC
have
different
underlying
biological
factors
driving
their
symptoms,
none
which
mutually
exclusive.
This
paper
details
mechanisms
by
RNA
viruses
beyond
just
be
connected
to
long-term
health
consequences.
also
reviews
literature
on
and
other
virus-initiated
chronic
syndromes
such
as
post-Ebola
myalgic
encephalomyelitis/chronic
fatigue
(ME/CFS)
discuss
scenarios
for
symptom
development.
Potential
contributors
include
consequences
from
injury
one
multiple
organs,
reservoirs
in
certain
tissues,
re-activation
neurotrophic
pathogens
herpesviruses
under
conditions
immune
dysregulation,
interactions
host
microbiome/virome
communities,
clotting/coagulation
issues,
dysfunctional
brainstem/vagus
nerve
signaling,
ongoing
activity
primed
cells,
autoimmunity
due
molecular
mimicry
between
pathogen
proteins.
individualized
nature
suggests
therapeutic
approaches
may
required
best
manage
care
specific
diagnosis.
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(6), P. 2099 - 2099
Published: June 19, 2021
Emerging
evidence
indicates
that
gut
microbiota
is
important
in
the
regulation
of
brain
activity
and
cognitive
functions.
Microbes
mediate
communication
among
metabolic,
peripheral
immune,
central
nervous
systems
via
microbiota–gut–brain
axis.
However,
it
not
well
understood
how
microbiome
neurons
mutually
interact
or
these
interactions
affect
normal
functioning
cognition.
We
summarize
mechanisms
whereby
regulate
production,
transportation,
neurotransmitters.
also
discuss
dysbiosis
affects
function,
especially
neurodegenerative
diseases
such
as
Alzheimer’s
disease
Parkinson’s
disease.
Molecular and Cellular Endocrinology,
Journal Year:
2022,
Volume and Issue:
546, P. 111572 - 111572
Published: Jan. 20, 2022
The
role
of
the
intestinal
microbiota
as
a
regulator
gut-brain
axis
signalling
has
risen
to
prominence
in
recent
years.
Understanding
relationship
between
gut
microbiota,
metabolites
it
produces,
and
brain
will
be
critical
for
subsequent
development
new
therapeutic
approaches,
including
identification
novel
psychobiotics.
A
key
focus
this
regard
have
been
short-chain
fatty
acids
(SCFAs)
produced
by
bacterial
fermentation
dietary
fibre,
which
include
butyrate,
acetate,
propionate.
Ongoing
research
is
focused
on
entry
SCFAs
into
systemic
circulation
from
lumen,
their
migration
cerebral
across
blood
barrier,
potential
exert
acute
chronic
effects
structure
function.
This
review
aims
discuss
our
current
mechanistic
understanding
direct
indirect
influence
that
function,
behaviour
physiology,
inform
future
microbiota-targeted
interventions
disorders.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(20), P. 7551 - 7551
Published: Oct. 13, 2020
The
gut
microbiome
acts
as
an
integral
part
of
the
gastrointestinal
tract
(GIT)
that
has
largest
and
vulnerable
surface
with
desirable
features
to
observe
foods,
nutrients,
environmental
factors,
well
differentiate
commensals,
invading
pathogens,
others.
It
is
well-known
a
strong
connection
central
nervous
system
(CNS)
in
context
health
disease.
A
healthy
diverse
microbes
vital
for
normal
brain
functions
emotional
behaviors.
In
addition,
CNS
controls
most
aspects
GI
physiology.
molecular
interaction
between
gut/microbiome
complex
bidirectional,
ensuring
maintenance
homeostasis
proper
digestion.
Besides
this,
several
mechanisms
have
been
proposed,
including
endocrine,
neuronal,
toll-like
receptor,
metabolites-dependent
pathways.
Changes
bidirectional
relationship
GIT
are
linked
pathogenesis
neurological
disorders;
therefore,
microbiota/gut-and-brain
axis
emerging
widely
accepted
concept.
this
review,
we
summarize
recent
findings
supporting
role
microbiota
immune
on
development
disorders.
highlight
advances
improving
diseases
by
probiotics/prebiotics/synbiotics
fecal
transplantation
via
concept
gut–brain
axis.
