Comparison Between Endobronchial Ultrasound-Guided Transbronchial Node Biopsy and Transbronchial Needle Aspiration: A Meta-Analysis DOI

Wuchen Yang,

Huizhen Yang,

Quncheng Zhang

et al.

Respiration, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: Aug. 13, 2024

Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) can be limited by the inadequacy of intact tissues, especially in patients with lymphoma, sarcoidosis, and lymph node tuberculosis. A novel technique called biopsy (TBNB) forceps or cryoprobe has been proposed studied to improve specimen quality diagnostic yield. We performed a systematic review studies describing safety sensitivity EBUS-TBNB versus EBUS-TBNA diagnosing intrathoracic lymphadenopathy/masses. Methods: systematically searched MEDLINE, Embase, Cochrane, China National Knowledge Infrastructure identify focusing on application for diagnosis lymphadenopathy. The each study was evaluated using QUADAS-2 tool. Using inverse-variance (I-V) weighting, we meta-analysis yield estimations. also reviewed complications related procedure. Results: Thirteen were included final analysis. yielded pooled overall 77.80% (939/1,207) 86.01% (834/958) EBUS-TBNB, an inverse-variance-weighted odds ratio 3.13 (95% confidence interval [CI], 1.61–6.01; p = 0.0008) I2 82%. malignancy (including primary lung cancer extrapulmonary malignancy) 84.53% (590/698) 90.84% (476/524) I-V-weighted OR 2.33 CI, 1.15–4.74; 0.02) 64%. benignancy 71.19% (252/354) 86.62% (233/269) 4.39 2.00–9.65; 0.002) 59%. bleeding (n 11, 0.90%), pneumomediastinum 6, 0.49%), pneumothorax pneumonia 4, 0.33%), respiratory failure 1, 0.08%), haemoptysis 0.08%). funnel plot analysis illustrated no major publication bias. Conclusions: improves sampling lymphadenopathy mass lesions relative EBUS-TBNA. complication rate is higher than that but reportedly lower surgical biopsies.

Language: Английский

Is the diagnostic yield of mediastinal lymph node cryobiopsy (cryoEBUS) better for diagnosing mediastinal node involvement compared to endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)? A systematic review DOI
Maribel Botana‐Rial, Irene Lojo-Rodríguez, Virginia Leiro‐Fernández

et al.

Respiratory Medicine, Journal Year: 2023, Volume and Issue: 218, P. 107389 - 107389

Published: Aug. 12, 2023

Language: Английский

Citations

24
EBUS-guided cryobiopsy in the diagnosis of thoracic disorders DOI Creative Commons
Venerino Poletti, Simone Petrarulo, Sara Piciucchi

et al.

Pulmonology, Journal Year: 2024, Volume and Issue: 30(5), P. 459 - 465

Published: Jan. 5, 2024

Endobronchial Ultrasound (EBUS) has emerged as a crucial tool for diagnosing intrathoracic disorders, particularly in the staging of lung cancer. However, its diagnostic capabilities context benign and rare diseases remain subject debate. to investigate yield safety EBUS-transbronchial mediastinal cryobiopsy (EBUS-TMC) comparison needle aspiration (TBNA) broad spectrum diseases. single-centre retrospective observational study conducted on 48 patients who underwent both EBUS-TBNA endobronchial ultrasound-transbronchial same procedure between August 2021 October 2023. The overall EBUS-TMC surpassed that (95.8% vs 54.1 %), notably excelling diagnosis sarcoidosis (92.8% 78.5 disorders (100% 0 hyperplastic lymphadenopathy lymphoproliferative disease %). No significant differences were observed NSCLC SCLC. Samples obtained through facilitated acquisition NGS immunohistochemical analyses more readily. may contribute precise subtyping diseases, especially lymphomas tumors, thereby reducing number non-diagnostic procedures.

Language: Английский

Citations

17
Comparison of cryobiopsy and forceps biopsy for the diagnosis of mediastinal lesions: A randomised clinical trial DOI Creative Commons
Tian‐Lu Cheng, Zhi‐Shu Huang, Jing Zhang

et al.

Pulmonology, Journal Year: 2024, Volume and Issue: 30(5), P. 466 - 474

Published: Jan. 5, 2024

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the standard approach for lung cancer staging. However, its diagnostic utility other mediastinal diseases might be hampered by limited tissue retrieved. Recent evidence suggests novel sampling strategies of forceps biopsy and cryobiopsy as auxiliary techniques to EBUS-TBNA, considering their capacity larger samples. This study determined added value diagnosis diseases. Consecutive patients with lesions 1 cm or more in short axis were enrolled. Following completion aspiration, three biopsies one performed a randomised pattern. Primary endpoints included yield defined percentage whom led definite diagnosis, procedure-related complications. In total, 155 recruited randomly assigned. Supplementing EBUS-TBNA either increased yield, no significant difference between plus (85.7 % versus 91.6 %, P = 0.106). Yet, samples obtained additional cryobiopsies qualified molecular testing than those from (100.0 89.5 0.036). When compared directly, overall was superior 70.8 0.001). Cryobiopsies produced greater shorter procedural time biopsies. Two (1.3 %) cases postprocedural pneumothorax detected. Transbronchial promising complementary tool supplement traditional harvesting. ChiCTR2000030373

Language: Английский

Citations

17
Cryoablation and immunity in non-small cell lung cancer: a new era of cryo-immunotherapy DOI Creative Commons
Antonio Vélez García‐Nieto, Andrew DeMaio, Daniel H. Sterman

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 21, 2023

Despite remarkable advances in tumor response and patient survival the past decade, systemic immunotherapies for lung cancer result an objective only around half of patients treated. On basis this limitation, combination strategies are being investigated to improve rates. Cryoablation has been proposed as one such technique induce immunogenic cell death synergize with immunotherapies, including immune checkpoint inhibitors. traditionally delivered percutaneously imaging guidance although recent technological allow bronchoscopic delivery. Herein, we review pre-clinical clinical evidence use cryoablation non-small potential induction anti-tumor immunity. We highlight ongoing studies involving approach propose areas future investigation.

Language: Английский

Citations

18
Endobronchial Ultrasound-Guided Transbronchial Mediastinal Cryobiopsy versus Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for Mediastinal Disorders: A Meta-Analysis DOI

Zhenming Zhang,

Shengping Li, Yu Bao

et al.

Respiration, Journal Year: 2024, Volume and Issue: 103(7), P. 359 - 367

Published: Jan. 1, 2024

Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy (EBUS-TMC), a novel technique, has been reported to improve the diagnostic value of endobronchial needle aspiration (EBUS-TBNA) for lesions in recent studies. Current literature suggests that this procedure greater efficacy compared conventional EBUS-TBNA. This systematic review and meta-analysis aimed evaluate yield complications associated with EBUS-TMC comparison EBUS-TBNA, thereby exploring potential technique enhancing utility lesions.

Language: Английский

Citations

6
Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy: a narrative review DOI Open Access
Hema Yamini Ramarmuty,

Masahide Oki

Mediastinum, Journal Year: 2024, Volume and Issue: 8, P. 2 - 2

Published: Jan. 10, 2024

Background and Objective: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive, safe, well-established method for diagnosing staging lung cancer other conditions associated with mediastinal lymphadenopathy. Efforts have been made to enhance the material adequacy of EBUS-TBNA, including recent introduction EBUS-guided cryobiopsy (EBUS-TMC). This advancement facilitates acquisition larger better-preserved tissue samples from mediastinum. We evaluated diagnostic accuracy safety EBUS-TMC in diagnosis malignant lesions its effectiveness relation benign conditions, such as tuberculosis sarcoidosis. Methods: searched PubMed® database relevant English articles published up July 1, 2023. Subsequently, we conducted comprehensive bibliographic analysis particular emphasis on yield, profile, procedural technicalities. Key Content Findings: Our narrative review, comprising seven publications, emphasizes significance an effective technique obtaining while maintaining excellent profile. Furthermore, capability molecular immunological non-small cell cancer. Conclusions: exhibits significant efficacy regard conditions. However, further studies are needed evaluate uncertainties regarding selection suitable cases technical intricacies.

Language: Английский

Citations

5
Utility and safety of endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy (EBUS-TMC): A systematic review and meta-analysis DOI Creative Commons

Pranay Sai Chandragiri,

Anshula Tayal, Saurabh Mittal

et al.

Lung India, Journal Year: 2024, Volume and Issue: 41(4), P. 288 - 298

Published: June 28, 2024

ABSTRACT Background: Modalities to improve tissue acquisition during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) have been investigated. Endobronchial mediastinal cryobiopsy (EBUS-TMC) is a modality obtain larger histological samples by inserting cryoprobe into the lesion. We aimed study diagnostic yield and safety of EBUS-TMC. Methods: performed systematic search PubMed Embase databases extract relevant studies. then meta-analysis calculate EBUS-TMC compare it with EBUS-TBNA. Results: Following search, we identified 14 studies (869 patients undergoing EBUS-TBNA). EBUS-TBNA from wherein both procedures were performed. The pooled was 92% (95% confidence interval [CI], 89%–95%). 81% CI, 77%–85%). risk difference in 11% 6%–15%, I 2 = 0%) when compared. only complication reported commonly minor bleeding. rate comparable Conclusion: provides greater similar adverse events compared Future are required clearly establish which most likely benefit this modality.

Language: Английский

Citations

5
Comparison of the specimen quality of endobronchial ultrasound‐guided intranodal forceps biopsy using standard‐sized forceps versus mini forceps for lung cancer: A prospective study DOI
Toshiyuki Nakai, Yuji Matsumoto, Takahiro Ueda

et al.

Respirology, Journal Year: 2024, Volume and Issue: 29(5), P. 396 - 404

Published: Jan. 21, 2024

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a diagnostic procedure with adequate performance; however, its ability to provide specimens of sufficient quality and quantity for treatment decision-making in advanced-stage lung cancer may be limited, primarily due blood contamination. The use 0.96-mm miniforceps biopsy (MFB) permits true histological sampling, but the resulting small are unsuitable intended applications. Therefore, we introduced 1.9-mm standard-sized forceps (SFB) compared utility that MFB.

Language: Английский

Citations

5
Endobronchial Ultrasound-guided Cryobiopsy of Pulmonary Artery Intimal Sarcoma DOI
Simone Petrarulo, Claudia Ravaglia,

Arianna Johanna De Grauw

et al.

American Journal of Respiratory and Critical Care Medicine, Journal Year: 2024, Volume and Issue: 209(12), P. 1497 - 1500

Published: April 17, 2024

"Endobronchial Ultrasound-guided Cryobiopsy of Pulmonary Artery Intimal Sarcoma." American Journal Respiratory and Critical Care Medicine, 0(ja), pp.

Language: Английский

Citations

4
A Review of Endobronchial-Ultrasound-Guided Transbronchial Intranodal Forceps Biopsy and Cryobiopsy DOI Creative Commons
Michel Chalhoub,

Bino Joseph,

Sudeep Acharya

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(9), P. 965 - 965

Published: May 6, 2024

Benign and malignant mediastinal lesions are not infrequently encountered in clinical practice. Mediastinoscopy has long been considered the gold standard evaluating pathology. Since its introduction into practice, endobronchial-ultrasonography-guided transbronchial fine needle aspiration (EBUS-TBNA) replaced mediastinoscopy as initial procedure of choice to evaluate stage lung cancer. Its diagnostic yield benign less common malignancies, however, remained limited. This led different proceduralists investigate additional procedures improve EBUS-TBNA. In recent years, published reports concluded that addition EBUS-guided intranodal forceps biopsy (IFB) cryobiopsy (TBCB) EBUS-TBNA increases especially uncommon malignancies. The purpose this review is describe how EBUS-IFB EBUS-TBCB performed, compare their yields, discuss limitations potential complications. addition, will conclude with a proposed algorithm on incorporate

Language: Английский

Citations

4