Assessing the Role of Cortisol in Anxiety, Major Depression, and Neuroticism: A Mendelian Randomization Study Using SERPINA6/SERPINA1 Variants

Biological Psychiatry Global Open Science, Journal Year: 2024, Volume and Issue: 4(3), P. 100294 - 100294

Published: Feb. 18, 2024

Previous evidence informed by the toxic stress model suggests that higher cortisol causes anxiety and major depression, but clinical success is lacking. To clarify role of cortisol, we used Mendelian randomization to estimate its associations with anxiety, neuroticism, leveraging largest available genome-wide association studies including from Psychiatric Genomics Consortium, UK Biobank, FinnGen.

Language: Английский

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Genetic and phenotypic similarity across major psychiatric disorders: a systematic review and quantitative assessment

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 30, 2024

Language: Английский

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Modeling environment through a general exposome factor in two independent adolescent cohorts

Exposome, Journal Year: 2022, Volume and Issue: 2(1)

Published: Jan. 1, 2022

Exposures to perinatal, familial, social, and physical environmental stimuli can have substantial effects on human development. We aimed generate a single measure that capture's the complex network structure of environment (ie, exposome) using multi-level data (participant's report, parent geocoded measures) exposures (primarily from psychosocial environment) in two independent adolescent cohorts: The Adolescent Brain Cognitive Development Study (ABCD Study, N = 11 235; mean age, 10.9 years; 47.7% females) an age- sex-matched sample Philadelphia Neurodevelopmental Cohort (PNC, 4993). conducted series data-driven iterative factor analyses bifactor modeling ABCD reducing dimensionality 348 variables tapping six orthogonal exposome subfactors general (adverse) factor. was associated with overall psychopathology (B 0.28, 95% CI, 0.26-0.3) key health-related outcomes: obesity (odds ratio [OR] , 1.4; 1.3-1.5) advanced pubertal development (OR, 1.3; 1.2-1.5). A similar approach PNC reduced 29 4 yielded consistent associations 0.15; 0.13-0.17), 1.3-1.6), 1-1.6). In both cohorts, inclusion factors greatly increased variance explained compared models relying solely demographics parental education (from <4% >38% ABCD; >18.5% PNC). Findings suggest capturing be derived consistently explain youth's mental health.

Language: Английский

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Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: April 4, 2024

Abstract The dominant (‘general’) version of the diathesis-stress theory depression views stressors and genetic vulnerability as independent risks. In Australian Genetics Depression Study ( N = 14,146; 75% female), we tested whether polygenic scores (PGS) for major depression, bipolar disorder, schizophrenia, anxiety, ADHD, neuroticism were associated with reported exposure to 32 childhood, past-year, lifetime, accumulated stressful life events (SLEs). false discovery rate-corrected models, clearest PGS-SLE relationships ADHD- depression-PGSs, a lesser extent, anxiety- schizophrenia-PGSs. We describe associations childhood SLEs, 2–3 strongest past-year/lifetime SLE associations. Higher ADHD-PGS was all SLEs (emotional abuse, emotional neglect, physical neglect; ORs 1.09–1.14; p’s < 1.3 × 10 − 5 ), more sudden violent death (OR 1.23; p 3.6 legal troubles 1.15; 0.003), accidental 1.14; 0.006). depression-PGS (ORs 1.07–1.12; 0.013), severe human suffering 1.17; assault weapon 1.12; living in unpleasant surroundings 1.11; 0.001). anxiety-PGS abuse 1.08; 1.6 4 serious accident 0.004), 2.2 transportation 1.07; schizophrenia-PGS 1.12–1.19; 9.3 8 1.16; 0.003). neuroticism-PGS 1.09; 0.007) financial 1.06; 0.014). A reversed pattern seen bipolar-PGS, lower odds 0.95; 0.014), 0.93; 0.92; 0.007). Genetic risk several mental disorders influences among adults moderately severe, recurrent depression. Our findings emphasise that diatheses are inter-dependent challenge diagnosis subtyping (e.g., reactive/endogenous) based on events.

Language: Английский

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Gene – maltreatment interplay in adult ADHD symptoms: main role of a gene–environment correlation effect in a Brazilian population longitudinal study

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

Language: Английский

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