Adolescents with Persistent Symptoms Following Acute SARS-CoV-2 Infection (Long-COVID): Symptom Profile, Clustering and Follow-Up Symptom Evaluation DOI Creative Commons
Marco Floridia, Danilo Buonsenso,

Laura Macculi

et al.

Children, Journal Year: 2024, Volume and Issue: 12(1), P. 28 - 28

Published: Dec. 27, 2024

Background: Few studies have evaluated long-COVID in adolescents. Methods: Cohort study. Demographics, clinical data, and the presence of 30 symptoms were collected with a modified WHO form. Mean values compared by Student’s t test proportions chi-square or Fisher test, trends over time analysed using for trend. Potential risk factors independently associated persisting multivariable logistic regression model. Clustering cases was two-step automatic clustering. Results: A total 97 adolescents aged 12–17 (54.6% females, 45.4% males) evaluated. After mean interval 96 days (SD 52) from acute infection, number (2.8 overall) higher pre-Omicron (3.2 vs. 2.5 Omicron, p = 0.046) moderate/severe infections (4.2 2.7 mild, 0.023). Fatigue (62.9%) dyspnea (43.3%) most common symptoms, followed headache (28.9%), thoracic pain (22.7%), diarrhea (20.6%), palpitations/tachycardia (17.5%), articular (15.5%), difficult concentration (14.4%), muscle (12.4%), taste reduction (8.2%), smell fever (6.2%), skin disorders (5.2%). The symptom profile similar males females but showed significant differences that observed concurrently adults. 340 45.3% still presented persistence initial symptoms. Two clusters defined differed phase infection Conclusions: Long-COVID manifestations may differ those Polisymptomaticity predict long-term persistence.

Language: Английский

Long-term multi-systemic complications following SARS-CoV-2 Omicron and Delta infection in children: a retrospective cohort study DOI
Liang En Wee, Jue Tao Lim,

Janice Yu Jin Tan

et al.

Clinical Microbiology and Infection, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

1
A Low Number of Baselines γδ T Cells Increases the Risk of SARS-CoV-2 Post-Vaccination Infection DOI Creative Commons
Juan Carlos Andreu‐Ballester, Lorena Galindo-Regal, Carmen Cuéllar

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(5), P. 553 - 553

Published: May 18, 2024

Background: The COVID-19 pandemic is the biggest global health problem in last hundred years. efficacy of vaccine to protect against severe disease estimated be 70–95% according studies carried out, although there are aspects immune response that remain unclear. Methods: Humoral and cellular immunity after administration three doses Pfizer–BioNTech Oxford AstraZeneca vaccines SARS-CoV-2 over one year appearance post-vaccination were studied. IgG IgA antibodies, αβ γδ T-cell subsets, their differentiation stages apoptosis analyzed. Results: Anti-SARS-CoV-2 antibodies showed a progressive increase throughout duration study. This was greatest third dose. highest levels observed subjects who had anti-SARS-CoV-2 prior vaccination. There an CD4+ αβ, CD8+ TEM T cells, decrease CD56+ cells. Post-vaccination infection greater than 60%. symptoms very mild related cell deficit, specifically TEMRA TEM, as well lower pre-vaccine levels. Conclusions: results unveil important role cells SARS-CoV-2-vaccine-mediated protection from disease.

Language: Английский

Citations

0
Adolescents with Persistent Symptoms Following Acute SARS-CoV-2 Infection (Long-COVID): Symptom Profile, Clustering and Follow-Up Symptom Evaluation DOI Creative Commons
Marco Floridia, Danilo Buonsenso,

Laura Macculi

et al.

Children, Journal Year: 2024, Volume and Issue: 12(1), P. 28 - 28

Published: Dec. 27, 2024

Background: Few studies have evaluated long-COVID in adolescents. Methods: Cohort study. Demographics, clinical data, and the presence of 30 symptoms were collected with a modified WHO form. Mean values compared by Student’s t test proportions chi-square or Fisher test, trends over time analysed using for trend. Potential risk factors independently associated persisting multivariable logistic regression model. Clustering cases was two-step automatic clustering. Results: A total 97 adolescents aged 12–17 (54.6% females, 45.4% males) evaluated. After mean interval 96 days (SD 52) from acute infection, number (2.8 overall) higher pre-Omicron (3.2 vs. 2.5 Omicron, p = 0.046) moderate/severe infections (4.2 2.7 mild, 0.023). Fatigue (62.9%) dyspnea (43.3%) most common symptoms, followed headache (28.9%), thoracic pain (22.7%), diarrhea (20.6%), palpitations/tachycardia (17.5%), articular (15.5%), difficult concentration (14.4%), muscle (12.4%), taste reduction (8.2%), smell fever (6.2%), skin disorders (5.2%). The symptom profile similar males females but showed significant differences that observed concurrently adults. 340 45.3% still presented persistence initial symptoms. Two clusters defined differed phase infection Conclusions: Long-COVID manifestations may differ those Polisymptomaticity predict long-term persistence.

Language: Английский

Citations

0