Effect of interaction between a specific subtype of child abuse and the FKBP5 rs1360780 SNP on DNA methylation among patients with bipolar disorder

Journal of Affective Disorders, Journal Year: 2020, Volume and Issue: 272, P. 417 - 422

Published: April 30, 2020

Language: Английский

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Gene–environment interactions between HPA-axis genes and childhood maltreatment in depression: a systematic review

Acta Neuropsychiatrica, Journal Year: 2020, Volume and Issue: 32(3), P. 111 - 121

Published: Jan. 6, 2020

Abstract Objective: Gene–environment (GxE) interactions may comprise an important part of the aetiology depression, and childhood maltreatment (CM), a significant stressor, has consistently been linked to depression. Hence, in this systematic review, we aimed investigate interaction between hypothalamus–pituitary–adrenal axis (HPA-axis) genes CM Methods: We conducted literature search using Pubmed, Embase, PsychINFO databases adherence with Preferred Reporting Items for Systematic reviews Meta-Analyses guidelines. included studies investigating GxE HPA-axis [ Angiotensin Converting Enzyme ( ACE ), Arginine Vasopressin AVP Corticotrophin Releasing Hormone CRH Receptor 1 CRHR1 2 CRHR2 FK506 binding protein FKBP5 Nuclear subfamily 3 group C member NR3C1 NR3C2 )] Results: The identified 159 potentially relevant studies. Following screening, 138 these were excluded. Thus, 21 studies, total 51 single nucleotide polymorphisms, final study. most prevalent current study . Significant reported seven eight :rs110402 CM, five :rs1360780 CM. In summary, our results suggest possible CRHR1, FKBP5, , respectively. For remaining genes, no emerged. Conclusions: find that genetic variation four influence effects

Language: Английский

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Targeting the Arginine Vasopressin V1b Receptor System and Stress Response in Depression and Other Neuropsychiatric Disorders

Neuropsychiatric Disease and Treatment, Journal Year: 2023, Volume and Issue: Volume 19, P. 811 - 828

Published: April 1, 2023

Abstract: A healthy stress response is critical for good mental and overall health promotes neuronal growth adaptation, but the intricately balanced biological mechanisms that facilitate a can also result in predisposition to disease when equilibrium disrupted. The hypothalamic-pituitary-adrenal (HPA) axis neuroendocrine system plays role body's adaptation stress, vasopressinergic regulation of HPA maintaining responsiveness during chronic stress. However, exposure repeated or excessive physical emotional trauma shift "new normal" underpinned by enduring changes function. Exposure early life due adverse childhood experiences lead lasting neurobiological changes, including impairment patients with depression considered among most reliable findings psychiatry, has been shown play major pathogenesis onset other neuropsychiatric disorders. Modulating activity, example via targeted antagonism vasopressin V 1b receptor, promising approach disorders associated impairment. Despite favorable preclinical indications animal models, demonstration clinical efficacy treatment depressive targeting dysfunction challenging, possibly heterogeneity syndromal nature Measures function, such as elevated cortisol levels, may be useful biomarkers identifying who benefit from treatments modulate activity. Utilizing identify subsets impaired function next step fine-tuning activity receptor. Keywords: allostatic overload, cortisol, axis, disorder,

Language: Английский

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Association of FKBP5 polymorphisms with patient susceptibility to coronary artery disease comorbid with depression

PeerJ, Journal Year: 2020, Volume and Issue: 8, P. e9286 - e9286

Published: June 3, 2020

Background Coronary artery disease (CAD) and depression cause great burden to society frequently co-occur. The exact mechanisms of this comorbidity are unclear. FK506-binding protein 51 (FKBP51) is correlated with cardiovascular depression. aim study was determine the role seven single nucleotide polymorphisms (SNPs) FKBP5 that code FKBP51, namely, rs1360780 (C>T), rs2817032 (T>C), rs2817035 (G>A), rs9296158 rs9470079 rs4713902 rs3800373 (C>T) in a patient’s susceptibility comorbid CAD Methods We enrolled 271 Northern Chinese Han patients CAD, including 123 147 without also included 113 healthy controls match patients’ sex age. Genomic DNA from whole blood extracted, SNPs were assessed using MassArray method. Patient Health Questionnaire-9 applied access Results GA genotype for associated significantly decreased risk (odds ratio = 0.506, 95% confidence interval 0.316–0.810, P 0.005) when GG used as reference. A statistically significant difference observed among females but not males allele frequency. Patients further divided into CAD+D CAD-D groups according presence compared controls. Significant differences found regarding frequency CAD+H control subjects all female ( < 0.05). Conclusions current remarkable association between gene variations north population. may be potential locus incidence

Language: Английский

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Hypothalamic stress systems in mood disorders

Handbook of clinical neurology, Journal Year: 2021, Volume and Issue: unknown, P. 33 - 48

Published: Jan. 1, 2021

Language: Английский

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Neuroprotective potential of Argan oil in neuropsychiatric disorders in rats: A review

Journal of Functional Foods, Journal Year: 2020, Volume and Issue: 75, P. 104233 - 104233

Published: Oct. 9, 2020

Argan Oil (AO), a natural vegetable oil, commonly used in folk Moroccan medicines. Preclinical studies, uphold that AO may exhibit neuroprotection against several aspects of neuropsychiatric disorders such as addiction, depression and epilepsy. This paper attempts to collate those experimental findings. Moreover, the benefits vitro on nerve cells is pointed out. principally composed mono- unsaturated saturated fatty acids. As minor components, it contains polyphenols, tocopherols sterols, among other. The reason for AO's obvious neuroprotective effects this review be due synergistic these bioactive compounds which are especially effective central nervous system. We suggest can result modulation brain antioxidant enzyme anti-inflammatory system, well by possible regulation stress axis neuroplasticity processes. Further studies needed fully characterize from neuro-pharmacological nutritional perspectives.

Language: Английский

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Interleukin-6-white matter network differences explained the susceptibility to depression after stressful life events

Journal of Affective Disorders, Journal Year: 2022, Volume and Issue: 305, P. 122 - 132

Published: March 8, 2022

Language: Английский

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The effect of negative life events on college students’ depression: the mediating role of internet addiction and the moderating role of 5-HTT1A gene rs6449693 polymorphism

Current Psychology, Journal Year: 2021, Volume and Issue: 42(8), P. 6555 - 6563

Published: June 21, 2021

Language: Английский

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Depressive and anxiety disorders

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 287 - 299

Published: Feb. 24, 2024

Language: Английский

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Prenatally traumatized mice reveal hippocampal methylation and expression changes of the stress-related genes Crhr1 and Fkbp5

Translational Psychiatry, Journal Year: 2021, Volume and Issue: 11(1)

Published: March 23, 2021

Abstract In our previous study, we found that prenatal trauma exposure leads to an anxiety phenotype in mouse pups, characterized by increased corticosterone levels and anxiety-like behavior. order understand the mechanisms which aversive utero experience these long-lasting behavioral neuroendocrine changes, investigated stress reactivity of prenatally traumatized (PT) mice, as well expression methylation several key regulatory genes axis dorsal hippocampus (dHPC) PT embryo adult mice. We detected corticotropin-releasing hormone receptor 1 ( Crhr1 ) decreased FK506 binding protein 5 Fkbp5 mRNA left dHPC These alterations were accompanied a status promoter promoter, respectively. Interestingly, changes not embryonic Together, findings provide evidence has long-term impact on function associated with altered transcripts methylation.

Language: Английский

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