Risk-benefit balance assessment of SSRI antidepressant use during pregnancy and lactation based on best available evidence – an update

Expert Opinion on Drug Safety, Journal Year: 2019, Volume and Issue: 18(10), P. 949 - 963

Published: Aug. 20, 2019

Introduction: Depression affects 300 million individuals worldwide. While selective serotonin reuptake inhibitors (SSRI) are one of the first-line pharmacological treatments major depression in general population, there is still uncertainty regarding their potential benefits and risks during pregnancy.Areas covered: Outcomes requisite for a proper risk/benefit assessment SSRI pregnancy lactation were considered: (a) associated with untreated depression, (b) effectiveness different treatment options (c) SSRI.Expert opinion: Despite growing amount literature on use pregnancy, no new trials assessing SSRIs maternal found. In light data risks, depressed SSRI-treated pregnant women children seem at increased risk several complications (mostly small absolute risk). The interpretation these findings remains quite similar to our previous review as available methodology does not allow disentangle effect from those disease itself or/and its unmeasured factors. Thus, or lactating who require treatment, can be considered appropriate when effective abundant support relative safety.

Language: Английский

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Exploring the influence of psychosocial factors on exclusive breastfeeding in Bangladesh

Archives of Women s Mental Health, Journal Year: 2016, Volume and Issue: 20(1), P. 173 - 188

Published: Nov. 12, 2016

Language: Английский

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Pregnancy, perinatal and postpartum complications as determinants of postpartum depression: the Rhea mother–child cohort in Crete, Greece

Epidemiology and Psychiatric Sciences, Journal Year: 2016, Volume and Issue: 27(3), P. 244 - 255

Published: Dec. 22, 2016

Aims. Few epidemiological studies evaluated associations between perinatal complications and maternal mood at the early postpartum period findings are inconsistent. We aimed investigating a wide range of during pregnancy, delivery, as determinants depression (PPD) 8 weeks postpartum. Methods. A total 1037 women who enrolled in Rhea mother–child cohort Crete, Greece participated present study. Information on was obtained from clinical records or by questionnaires. Postpartum depressive symptoms were assessed using Edinburgh Postnatal Depression Scale (EPDS). Multivariable linear logistic regression models fit to estimate association symptoms, adjusting also for potential confounders. Results. The prevalence with probable (EPDS score ≥ 13) 13.6% Gestational hypertension and/or preeclampsia ( β coefficient 1.86, 95% CI: 0.32, 3.41) breastfeeding difficulties 0.77, 0.02, 1.53) significantly associated higher PPD symptoms. Sleep patterns such sleep deprivation (OR = 3.57, 1.91, 6.67) snoring 1.81, 1.11, 2.93), duration less than 2 months 1.77, 1.19, 2.64) increase odds PPD. Some other complications, unplanned pregnancy hospitalisation EPDS score, but these explained socio-demographic characteristics mother. Conclusions. found that several may have an adverse effect period. These considerable implications developing effective prevention psychoeducational intervention strategies risk

Language: Английский

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Oxytocin course over pregnancy and postpartum period and the association with postpartum depressive symptoms

Archives of Women s Mental Health, Journal Year: 2016, Volume and Issue: 19(4), P. 571 - 579

Published: June 20, 2016

Language: Английский

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Breastfeeding and postpartum depression: Assessing the influence of breastfeeding intention and other risk factors

Journal of Affective Disorders, Journal Year: 2016, Volume and Issue: 200, P. 45 - 50

Published: April 22, 2016

Language: Английский

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