Augmenting Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder with Transcranial Infrared Laser Stimulation

Biological Psychiatry Global Open Science, Journal Year: 2025, Volume and Issue: 5(2), P. 100449 - 100449

Published: Jan. 9, 2025

Transcranial infrared laser stimulation (TILS) is a noninvasive form of photobiomodulation that facilitates prefrontal energy metabolism and oxygenation, resulting in cognitive-enhancing effects. Cognitive behavioral therapy mainstream treatment for major depressive disorder. This the first study to investigate whether TILS would augment antidepressant effects internet-based cognitive therapy. Sixty participants with disorder were given access Deprexis, therapy, 12 weeks. After 2 weeks, 40 who had improved at least 10% symptoms from baseline as measured by Quick Inventory Depressive Symptomatology-Self-Report randomly assigned Deprexis combination or sham/placebo. There no significant group differences demographics initial depression data. was 43% reduction scores sham score week score, while adding an adjunct resulted 56%. Therefore, additional 30% ([56-43]/43 = 30%). Participants received right forehead once 4 weeks showed significantly greater than reported adverse While alone reduced placebo control group, this beneficial effect augmented addition Additional research pairs neuroenhancement methods such interventions may reveal potential improve outcomes other psychiatric disorders.

Language: Английский

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Photobiomodulation combination therapy as a new insight in neurological disorders: a comprehensive systematic review

BMC Neurology, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 19, 2024

Abstract Preclinical and clinical studies have indicated that combining photobiomodulation (PBM) therapy with other therapeutic approaches may influence the treatment process in a variety of disorders. The purpose this systematic review was to determine whether PBM-combined provides additional benefits over monotherapies neurologic neuropsychiatric In addition, describes most commonly used methods PBM parameters these conjunctional approaches. To accomplish this, search conducted Google Scholar, PubMed, Scopus databases through January 2024. 95 potentially eligible articles on strategies for neurological neuropsychological disorders were identified, including 29 preclinical 66 trials. According findings, seven major categories identified based disease type: diseases, neurodegenerative ischemia, nerve injury, pain, paresis, neuropathy. These looked at effects laser combination therapies like pharmacotherapies, physical therapies, exercises, stem cells, experimental materials both animal models humans. findings suggested could produce synergistic effects, leading better outcomes treating psychiatric relieving symptoms. indicate be useful adjunct conventional treatments psychological

Language: Английский

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Devices used for photobiomodulation of the brain—a comprehensive and systematic review

Journal of NeuroEngineering and Rehabilitation, Journal Year: 2024, Volume and Issue: 21(1)

Published: April 10, 2024

Abstract A systematic review was conducted to determine the trends in devices and parameters used for brain photobiomodulation (PBM). The revised studies included clinical cadaveric approaches, which light stimuli were applied head and/or neck. PubMed, Scopus, Web of Science Google Scholar databases search. total 2133 records screened, from 97 this review. that extracted analysed each article device design, actuation area, site, wavelength, mode operation, power density, energy output, per session treatment time. To organize information, 11 categories defined, according their characteristics. most category laser handpieces, relate 21% all devices, while 28% not described. Studies cognitive function physiological characterisation are well defined ones with more tangible results. There is a lack consistency when reporting PBM studies, several articles under defining stimulation protocol, wide variety same health conditions (e.g., Alzheimer’s or Parkinson’s disease) resulting positive outcomes. Standardization report these warranted, as sham-controlled comparative have greatest effect on treatments different neurological conditions.

Language: Английский

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Anxiety as a disorder of uncertainty: implications for understanding maladaptive anxiety, anxious avoidance, and exposure therapy

Cognitive Affective & Behavioral Neuroscience, Journal Year: 2023, Volume and Issue: 23(3), P. 844 - 868

Published: March 3, 2023

Language: Английский

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Stimulation of the ventromedial prefrontal cortex blocks the return of subcortically mediated fear responses

Translational Psychiatry, Journal Year: 2022, Volume and Issue: 12(1)

Published: Sept. 20, 2022

Abstract The ventromedial prefrontal cortex (vmPFC) mediates the inhibition of defensive responses upon encounters cues, that had lost their attribute as a threat signal via previous extinction learning. Here, we investigated whether such fear recall can be facilitated by anodal transcranial direct current stimulation (tDCS). Extinction was tested twenty-four hours after previously acquired extinguished. Either tDCS or sham targeting vmPFC applied during this test. After ceased, examined return subjects been re-exposed to aversive events. Fear assessed reports expectancy and modulations autonomic (skin conductance, heart rate) protective reflex (startle potentiation) measures, latter which are mediated subcortical defense circuits. While did not affect initial recall, it abolished startle potentiation components response. Results suggest hierarchical multi-level functions in human indicate, its might immunize against relapses into pathological subcortically activation.

Language: Английский

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Translating Research on Cognitive Enhancement and Brain Plasticity into Action

Oxford University Press eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract This chapter addresses how militaries have led and leveraged decades of neuroplasticity neuromodulation research to enhance the cognitive performance military service members improve national security. There are several key application areas in domain that may benefit most from enhancement development, such as decision-making, creativity, learning, rapid expertise fatigue countermeasures, enhanced resiliency against stress, others. Many governmental programs around world funded internationally recognized interdisciplinary researchers explore novel approaches for provides a brief overview some compelling investments research, while also highlighting differences between use similar tools by general population. The discusses ethical considerations able-bodied active-duty members. Finally, potential future avenues next wave applications, light recent developments neurotechnology.

Language: Английский

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Cognitive improvement and prefrontal network interactions in individuals with remitted bipolar disorder after transcranial infrared laser stimulation

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 30, 2025

Background Converging evidence suggests that bipolar disorder (BD) involves mitochondrial dysfunction and prefrontal cortex (PFC) hypometabolism associated with cognitive impairment, which persists in remitted BD individuals. Transcranial infrared laser stimulation (TILS) provides safe, non-invasive brain enhances PFC metabolism via photobiomodulation of respiration tissue oxygenation. We tested the hypothesis neurocognitive deficits found may be ameliorated by TILS treatments. Methods This is first study to explore effects repeated administration BD. Using an open-label design, 29 individuals received six weekly Working memory attention were assessed trail-making 2-back tasks sensitive Changes network interactions measured functional near-infrared spectroscopy (fNIRS) because this method can measure on oxygen Results Participants reported no adverse from treatment, confirming safety intervention Cognitive test results showed people BD, was effective at improving cognition, i.e., enhanced speed accuracy reflecting flexibility, working memory, attentional control. Antipsychotic medication improved effects. The fNIRS a significant reduction correlations oxygenated hemoglobin changes driven task performance. right-hemisphere frontopolar greater than its left-hemisphere counterpart. Conclusions Repeated safe improve cognition Continued antipsychotic have contributed improvement. To confirm efficacy, sham-controlled, double-blinded randomized trial needed. Clinical registration https://clinicaltrials.gov/ , identifier NCT05354895.

Language: Английский

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Beyond digital therapy: Augmenting internet-based CBT with brain stimulation

Biological Psychiatry Global Open Science, Journal Year: 2025, Volume and Issue: unknown, P. 100514 - 100514

Published: May 1, 2025

Language: Английский

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Prefrontal photobiomodulation produces beneficial mitochondrial and oxygenation effects in older adults with bipolar disorder

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Oct. 31, 2023

There is growing evidence of mitochondrial dysfunction and prefrontal cortex (PFC) hypometabolism in bipolar disorder (BD). Older adults with BD exhibit greater decline PFC-related neurocognitive functions than expected for age-matched controls, clinical interventions intended mood stabilization are not targeted to prevent or ameliorate deficits this population. Transcranial infrared laser stimulation (TILS) a non-invasive form photobiomodulation, which photons delivered the PFC photo-oxidize respiratory enzyme, cytochrome-c-oxidase (CCO), major intracellular photon acceptor photobiomodulation. TILS at 1064-nm can significantly upregulate oxidized CCO concentrations promote differential levels oxygenated vs. deoxygenated hemoglobin (HbD), an index cerebral oxygenation. The objective controlled study was use broadband near-infrared spectroscopy assess if bilateral (Brodmann area 10) produces beneficial effects on oxidative energy metabolism (oxidized CCO) oxygenation (HbD) older (≥50 years old) euthymic ( N = 15). As compared sham, increased both during after TILS, HbD TILS. By increasing above sham levels, has potential ability stabilize production damage BD. In conclusion, safe effective enhancing metabolic function subsequent hemodynamic responses PFC, might help alleviate accelerated dysfunctional mitochondria present

Language: Английский

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Histochemical mapping of the duration of action of photobiomodulation on cytochrome c oxidase in the rat brain

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Aug. 28, 2023

Introduction This is the first study mapping duration of action in vivo photobiomodulation (PBM) on cytochrome-c-oxidase (CCO). In cellular bioenergetics, CCO terminal rate-limiting enzyme mitochondrial electron transport chain, which catalyzes oxygen utilization for aerobic energy production. PBM using transcranial infrared laser stimulation (TILS) a promising intervention non-invasively modulating brain. TILS human prefrontal cortex directly causes photo-oxidation, associated with increased cerebral oxygenation and improved cognition. Methods experiment aimed to map activity discrete neuroanatomic locations within rat brains up 4 weeks after single session (50 s, 1064 nm CW, 250 mW/cm 2 ). Control from rats treated sham without (laser off) were compared TILS-treated that collected 1 day, weeks, or post-TILS. Cryostat sections 36 processed quantitative histochemistry digitally imaged. Densitometric readings 28 regions interest recorded converted units calibration standards. Data analysis (ANCOVA) each laser-treated group whole-brain average as covariate. Results The infralimbic showed earliest significant increase between 1-day post-TILS groups, continued elevated 2–4 Significant differences 2-weeks groups also found lateral septum, accumbens core, CA3 hippocampus, molecular layer hippocampus. medial amygdala decrease 4-weeks sham. Further analyses inter-regional correlations among brain result TILS, most pronounced changes at post-stimulation. Discussion time course network connectivity suggested caused different neuroplasticity types bioenergetic scales, depending region its depth cortex. conclusion, this controlled histochemical demonstrated long-lasting

Language: Английский

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