Fronto-limbic neural variability as a transdiagnostic correlate of emotion dysregulation

Translational Psychiatry, Journal Year: 2021, Volume and Issue: 11(1)

Published: Oct. 21, 2021

Abstract Emotion dysregulation is central to the development and maintenance of psychopathology, common across many psychiatric disorders. Neurobiological models emotion involve fronto-limbic brain network, including in particular amygdala prefrontal cortex (PFC). Neural variability has recently been suggested as an index cognitive flexibility. We hypothesized that within-subject neural network would be related inter-individual variation context low affective control. In a multi-site cohort ( N = 166, 93 females) healthy individuals with emotional (attention deficit/hyperactivity disorder (ADHD), bipolar (BD), borderline personality (BPD)), we applied partial least squares (PLS), multivariate data-driven technique, derive latent components yielding maximal covariance between blood-oxygen level-dependent (BOLD) signal at rest dysregulation, expressed by lability, depression mania scores. PLS revealed one significant component r 0.62, p 0.044), whereby greater was associated increased amygdala, hippocampus, ventromedial, dorsomedial dorsolateral PFC, insula motor cortex, decreased occipital regions. This spatial pattern bears striking resemblance which thought subserve regulation, impaired ADHD, BD, BPD. Our work supports transdiagnostic dimension neurobiological underpinnings transcend diagnostic boundaries, adds evidence being relevant proxy efficiency.

Language: Английский

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Threat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents

Developmental Science, Journal Year: 2022, Volume and Issue: 26(1)

Published: April 13, 2022

Abstract Exposure to childhood adversity has been consistently associated with poor developmental outcomes, but it is unclear whether these associations vary across different forms of adversity. We examined cross‐sectional and longitudinal between threat deprivation cognition, emotional processing, psychopathology in a middle‐income country. The sample consisted 2511 children adolescents (6–17 years old) from the Brazilian High‐Risk Cohort for Mental Conditions. Parent reports on were used construct latent constructs. Psychopathology was measured by Child Behavior Checklist (CBCL) generate measure general (the “p” factor). Executive function (EF) attention orienting toward angry faces assessed using cognitive tasks. All measures acquired at two time‐points 3 apart tested linear models. Higher levels predicted higher cross‐sectionally longitudinally, longitudinally. For EF, worse performance only baseline follow‐up. Finally, towards cross‐sectionally, neither form changes over time bias. Our results suggest that have differential development psychopathology. during complex phenomenon meaningful influences child development. Because can take many forms, dimensional models might help disentangle specific correlates types early experience. A video abstract this article be viewed https://www.youtube.com/watch?v=uEU0L8exyTM .

Language: Английский

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Sensitive periods in development and risk for psychiatric disorders and related endpoints: a systematic review of child maltreatment findings

The Lancet Psychiatry, Journal Year: 2022, Volume and Issue: 9(12), P. 978 - 991

Published: Nov. 17, 2022

Language: Английский

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Child maltreatment exposure and adolescent nonsuicidal self-injury: the mediating roles of difficulty in emotion regulation and depressive symptoms

Child and Adolescent Psychiatry and Mental Health, Journal Year: 2023, Volume and Issue: 17(1)

Published: Jan. 28, 2023

Although child maltreatment (CM) experiences are recognized risk factors for nonsuicidal self-injury (NSSI), the mechanisms underlying this relationship remain unclear. The purpose of study was to examine whether difficulty in emotion regulation (DER) and depressive symptoms mediate between NSSI severity, adjusting demographic variables.The participants were 224 adolescent inpatients recruited from a hospital China (mean age 15.30 years, SD = 1.83; 78.6% females). Study measures included Clinician-Rated Severity Nonsuicidal Self-Injury (CRSNSSI), Childhood Trauma Questionnaire (CTQ-SF), Difficulties Emotion Regulation Scale (DERS), Patient Health Questionnaire-9 (PHQ-9). hypothesized chain mediation model tested using structural equation model.A total 146 (65.18%) adolescents reported engaging during past 12 months, 103 (45.98%) met DSM-5 diagnostic criteria NSSI. Emotional neglect (48.1%) emotional abuse (46.1%) had highest prevalence, followed by physical (43.1%) (24.1%), whereas sexual (12.5%) least prevalent form CM. Separately, both DER significantly mediated association CM NSSI, with being strongest mediator, an indirect effect 49.40% (p 0.014). At same time, we also proved potential chain-mediated pathway depression NSSI.Child seems play role aetiology have mediating Importantly, be mediator stronger compared symptoms.

Language: Английский

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Adverse childhood experiences and aggression in adulthood: The moderating role of positive childhood experiences

Child Abuse & Neglect, Journal Year: 2024, Volume and Issue: 154, P. 106929 - 106929

Published: July 4, 2024

Adverse childhood experiences (ACEs) have a significant impact on person's psychological development and predispose them to various harmful consequences in adulthood, such as different forms of aggression. Contrarily, positive (PCEs) operate protective factors, buffering against the adverse effects ACEs promoting adaptive behaviors well-being. However, role PCEs relationship between aggression remains relatively unexplored.

Language: Английский

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Low Emotional Awareness as a Transdiagnostic Mechanism Underlying Psychopathology in Adolescence

Clinical Psychological Science, Journal Year: 2020, Volume and Issue: 8(6), P. 971 - 988

Published: July 22, 2020

The ability to identify and label one’s emotions is associated with effective emotion regulation, rendering emotional awareness important for mental health. We evaluated how was related psychopathology whether low a transdiagnostic mechanism explaining the increase in during transition adolescence as function of childhood trauma—specifically, violence exposure. In Study 1, children adolescents ( N = 120, age range 7–19 years) reported on psychopathology. Emotional negatively (p-factor) worsened across females but not males. 2 262, 8–16 years), we replicated these findings demonstrated longitudinally that mediated increases p-factor These indicate may be linking adolescent development, sex, trauma emergence

Language: Английский

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Altered Neural Processing of Threat-Related Information in Children and Adolescents Exposed to Violence: A Transdiagnostic Mechanism Contributing to the Emergence of Psychopathology

Journal of the American Academy of Child & Adolescent Psychiatry, Journal Year: 2019, Volume and Issue: 59(11), P. 1274 - 1284

Published: Aug. 29, 2019

Language: Английский

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Immediate impact of child maltreatment on mental, developmental, and physical health trajectories

Journal of Child Psychology and Psychiatry, Journal Year: 2022, Volume and Issue: 63(9), P. 1027 - 1045

Published: March 9, 2022

Objective The immediate impact of child maltreatment on health and developmental trajectories over time is unknown. Longitudinal studies starting in the direct aftermath exposure with repeated follow‐up are needed. Method We assessed outcomes 6‐month intervals 2 years 173 children, aged 3–5 at study entry, including 86 children to emotional physical abuse or neglect within 6 months 87 nonmaltreated children. Assessments included clinician‐administered, self‐ parent‐report measures psychiatric behavioral symptoms, development, health. Linear mixed models latent growth curve analyses were used contrast between groups investigate features trajectories. Results Maltreated exhibited greater numbers diagnoses ( b = 1.998, p < .001), externalizing 13.29, .001) internalizing 11.70, impairments cognitive −11.586, verbal −10.687, motor development −7.904, .006), medical symptoms 1.021, compared across all time‐points. Lifetime severity and/or age earliest predicted adverse time. Conclusion profound, immediate, stable supports a biological embedding model provides foundation scrutinize precise underlying mechanisms. Such knowledge will enable early risk markers mechanism‐driven interventions that mitigate maltreated

Language: Английский

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Emotion Regulation Strategies as Risk Factors for Developmental Psychopathology: a Meta-analytic Review of Longitudinal Studies based on Cross-lagged Correlations and Panel Models

Research on Child and Adolescent Psychopathology, Journal Year: 2022, Volume and Issue: 51(3), P. 295 - 315

Published: Oct. 8, 2022

Language: Английский

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Experience-driven plasticity and the emergence of psychopathology: A mechanistic framework integrating development and the environment into the Research Domain Criteria (RDoC) model.

Journal of Psychopathology and Clinical Science, Journal Year: 2022, Volume and Issue: 131(6), P. 575 - 587

Published: July 28, 2022

Despite the clear importance of a developmental perspective for understanding emergence psychopathology across life-course, such has yet to be integrated into Research Domain Criteria (RDoC) model. In this paper, we articulate framework that incorporates developmentally specific learning mechanisms reflect experience-driven plasticity as additional units analysis in existing RDoC matrix. These include both experience-expectant occur during sensitive periods development and experience-dependent may exhibit substantial variation development. Incorporating these allows integration not only but also environmental experience We demonstrate how individual differences experiences-such early life adversity-can leveraged identify patterns apply consider shapes key biobehavioral processes comprise This provides structure affective, cognitive, social, neurobiological are shaped by ultimately contribute psychopathology. incorporating an is critical many subsumed within model, which will greater etiology can potential windows heightened when clinical interventions might maximally efficacious. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Language: Английский

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