In search of convergent regional brain abnormality in cognitive emotion regulation: A transdiagnostic neuroimaging meta‐analysis DOI Creative Commons
Tina khodadadifar,

Zahra Soltaninejad,

Amir Ebneabbasi

et al.

Human Brain Mapping, Journal Year: 2021, Volume and Issue: 43(4), P. 1309 - 1325

Published: Nov. 26, 2021

Abstract Ineffective use of adaptive cognitive strategies (e.g., reappraisal) to regulate emotional states is often reported in a wide variety psychiatric disorders, suggesting common characteristic across different diagnostic categories. However, the extent shared neurobiological impairments incompletely understood. This study, therefore, aimed identify transdiagnostic neural signature disturbed reappraisal using coordinate‐based meta‐analysis (CBMA) approach. Following best‐practice guidelines for conducting neuroimaging meta‐analyses, we systematically searched PubMed, ScienceDirect, and Web Science databases tracked references. Out 1,608 identified publications, 32 whole‐brain studies were retrieved that compared brain activation patients with disorders healthy controls during task. Then, peak coordinates group comparisons extracted several likelihood estimation (ALE) analyses performed at three hierarchical levels potential spatial convergence: global level (i.e., pooled analysis increased/decreased activations), experimental‐contrast grouped data based on regulation goal, stimulus valence, instruction rule) disorder‐group focused increasing homogeneity disorders). Surprisingly, none our provided significant convergent findings. CBMA indicates lack regional abnormality related task, probably due complex nature emotion regulation, heterogeneity clinical populations, and/or experimental statistical flexibility individual studies.

Language: Английский

Emotion regulation strategy and its relationship with emotional dysregulation in children with attention-deficit/hyperactivity disorder: behavioral and brain findings DOI

Qianrong Liu,

Yuan Ping Feng, Wai Chen

et al.

European Child & Adolescent Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Language: Английский

Citations

1
BOLD signal variability as potential new biomarker of functional neurological disorders DOI Creative Commons

Ayla Schneider,

Samantha Weber,

Anna Wyss

et al.

NeuroImage Clinical, Journal Year: 2024, Volume and Issue: 43, P. 103625 - 103625

Published: Jan. 1, 2024

Functional neurological disorder (FND) is a common neuropsychiatric condition with established diagnostic criteria and effective treatments but for which the underlying neuropathophysiological mechanisms remain incompletely understood. Recent neuroimaging studies have revealed FND as multi-network brain disorder, unveiling alterations across limbic, self-agency, attentional/salience, sensorimotor networks. However, relationship between identified disease progression or improvement less explored.

Language: Английский

Citations

8
The emerging neuroimmune hypothesis of bipolar disorder: An updated overview of neuroimmune and microglial findings DOI Creative Commons
Adriano José Maia Chaves Filho,

Capri Eyres,

Leonie Blöbaum

et al.

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: March 19, 2024

Abstract Bipolar disorder (BD) is a severe and multifactorial disease, with onset usually in young adulthood, which follows progressive course throughout life. Replicated epidemiological studies have suggested inflammatory mechanisms neuroimmune risk factors as primary contributors to the development of BD. While not all patients display overt markers inflammation, significant evidence suggests that aberrant immune signaling contributes stages disease seems be mood phase dependent, likely explaining heterogeneity findings observed this population. As brain's cells, microglia orchestrate response play critical role maintaining health across lifespan. Microglia are also highly sensitive environmental changes respond physiological pathological events by adapting their functions, structure, molecular expression. Recently, it has been highlighted instead single population comprise heterogeneous community specialized states adjusted according local cues intercellular interactions. Early contribution BD neuropathology, notably for outcomes, such suicidality. However, roles diversity microglial still largely undermined. This review brings an updated overview current literature on progression BD, most prominent abnormalities (including biomarker, neuroimaging, ex vivo studies) recent involvement neuropathology. Combining these different shreds evidence, we aim propose unifying hypothesis pathophysiology centered microglia. Also, highlight urgent need apply novel multi‐system biology approaches characterize functions involved enigmatic disorder, can open bright perspectives biomarkers therapeutic discoveries.

Language: Английский

Citations

6
Role of fronto-limbic circuit in neuropsychiatric symptoms of dementia: clinical evidence from an exploratory study DOI Creative Commons
Matteo Cotta Ramusino, Camillo Imbimbo, Marco Capelli

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: May 10, 2024

Background Neuropsychiatric symptoms (NPSs) are a distressful aspect of dementia and the knowledge structural correlates NPSs is limited. We aimed to identify associations fronto-limbic circuit with specific in patients various types cognitive impairment. Methods Of 84 participants, 27 were diagnosed mild impairment (MCI), 41 Alzheimer’s disease (AD) 16 non-AD dementia. In all we assessed regional brain morphometry using region interest (ROI)-based analysis. The mean cortical thickness (CT) 20 regions volume (V) 4 subcortical areas system extracted. rated Inventory (NPI). used multiple linear regression models adjusted for age duration significant between scores NPI sub-domains MRI measures morphometry. Results All found negative, except those irritability fronto-opercular MCI (corresponding 40-50% increase CT) delusions hippocampus anterior cingulate gyrus (with 40-60% increase). Apathy showed predominant involvement inferior frontal AD group (a 30% decrease cortex 50-60% CT). Anxiety correlated caudate, CT V about 40%, while hallucinations associated left enthorinal right amygdala temporal pole. Agitation pole, corresponding 30-40% CT. Euphoria, disinhibition eating abnormalities entorhinal, para-hippocampal fusiform gyri, pole 40-70% V). Finally, aberrant motor behavior reported association 50% Conclusion Our findings indicate that across different neurocognitive disorders. Factors, such as duration, can partly account variability observed.

Language: Английский

Citations

6
Diagnostic validity of premenstrual dysphoric disorder: revisited DOI Creative Commons

Shalini S. Naik,

Yadav Nidhi,

Krishan Kumar

et al.

Frontiers in Global Women s Health, Journal Year: 2023, Volume and Issue: 4

Published: Nov. 27, 2023

The World Health Organization (WHO) and American Psychiatric Association (APA) have recognised premenstrual dysphoric disorder (PMDD) as an independent diagnostic entity, legitimising the distress socio-occupational impairment experienced by affected women. However, biological validity of this diagnosis remains inexplicit. This illness has also been criticised for a feminist-led, sympathetic reaction to modern cultural challenges urban, literate, employed, high-functioning article systematically reviews existing literature on PMDD using criteria established Robins Guze psychiatric (clinical description, laboratory study, exclusion other disorders, follow-up family study). Despite early recognition syndrome (PMS) in 1950s, research encountered due two groups proponents viewing it with psychologising bias medicalising bias. is currently understood most severe form PMS, characterised presence psychological features. Recent evidence suggests that perhaps neurodevelopmental underpinnings (attention deficit hyperactive disorder, adverse childhood experiences) affecting fronto-limbic circuit regulates emotions. In addition, individuals exhibit increased sensitivity gonadal hormonal fluctuations observed during premenstrual, pregnancy, perimenopausal phases life. prevalence comparable between high-income countries low- middle-income (LAMIC), refuting notion mostly affects Instead, greater LAMIC. fact educated women possess knowledge regarding importance getting help, there prevalent issue inadequate help-seeking behaviour. can be attributed perception seeking help isolating experience, which influenced profound internalised stigma discrimination workplace. Future studies must aim develop culturally validated assessment tools more understand life course illness, addition examining validators (animal models, genetics, imaging, neurotransmitters).

Language: Английский

Citations

12
Brain imaging derived phenotypes: a biomarker for the onset of inflammatory bowel disease and a potential mediator of mental complications DOI Creative Commons
Fan Li,

Qi Zhao,

Tongyu Tang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 26, 2024

Background and aims Inflammatory bowel disease (IBD), mainly categorized into Crohn’s (CD) ulcerative colitis (UC), is a chronic relapsing gastrointestinal disorder that significantly impairs patients’ quality of life. IBD patients often experience comorbidities such as anxiety depression, the underlying mechanisms treatment strategies remain areas investigation. Methods We conducted Mendelian randomization(MR) analysis utilizing brain image derived phenotypes (IDP) from UK Biobank database to investigate causal relationships between alterations in structural morphology connectivity neural tracts. This study aimed identify biological evidence linking psychiatric disorders depression. Results Specifically, volume grey matter Left Frontal Orbital Cortex exhibited negative association with onset (odds ratio (OR) [95% confidence interval (CI)]: 0.315[0.180~0.551], adjusted P=0.001), while superior frontal cortex right hemisphere showed positive correlation development Ulcerative (OR CI]: 2.285[1.793~2.911], P<0.001), lateral occipital left demonstrated relationship 1.709[1.671~1.747], P<0.001). In context reverse causality, UC or CD has led imaging associated five (anxiety, schizophrenia, bipolar disorder, pain) three functions (memory, emotion, language). Conclusion Our IDPs. IDPs may serve potential biomarkers for progression predictive intermediaries neurological diseases patients.

Language: Английский

Citations

4
Task-specific relationships between error-related ERPs and behavior: Flanker, Stroop, and Go/Nogo tasks DOI
Bohyun Park, Amanda Holbrook, Miranda Christine Lutz

et al.

International Journal of Psychophysiology, Journal Year: 2024, Volume and Issue: 204, P. 112409 - 112409

Published: Aug. 8, 2024

Language: Английский

Citations

4
Functional brain network dynamics mediate the relationship between female reproductive aging and interpersonal adversity DOI Creative Commons
Raluca Petrican, Sidhant Chopra, Ashlea Segal

et al.

Nature Mental Health, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Premature reproductive aging is linked to heightened stress sensitivity and psychological maladjustment across the life course. However, brain dynamics underlying this relationship are poorly understood. Here, address issue, we analyzed multimodal data from female participants in Adolescent Brain Cognitive Development (longitudinal, N = 441; aged 9–12 years) Human Connectome-Aging (cross-sectional, 130; 36–60 studies. Age-specific intrinsic functional network mediated link between perceptions of greater interpersonal adversity. The adolescent profile overlapped areas glutamatergic dopaminergic receptor density, middle-aged was concentrated visual, attentional default mode networks. two profiles showed opposite relationships with patterns neural variability cortical atrophy observed psychosis versus major depressive disorder. Our findings underscore divergent maturation senescence, which may explain developmentally specific vulnerabilities distinct disorders.

Language: Английский

Citations

0
THE PROMISE OF INVESTIGATING NEURAL VARIABILITY IN PSYCHIATRIC DISORDERS DOI Creative Commons
Konstantinos Tsikonofilos, Arvind Kumar, Konstantinos Ampatzis

et al.

Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Synaptic-dependent developmental dysconnectivity in 22q11.2 deletion syndrome DOI Creative Commons

Filomena Grazia Alvino,

Silvia Gini, Antea Minetti

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(11)

Published: March 12, 2025

Chromosome 22q11.2 deletion increases the risk of neuropsychiatric disorders like autism and schizophrenia. Disruption large-scale functional connectivity in 22q11 syndrome (22q11DS) has been widely reported, but biological factors driving these changes remain unclear. We used a cross-species design to uncover developmental trajectory neural underpinnings brain dysconnectivity 22q11DS. In LgDel mice, model for 22q11DS, we found age-specific patterns dysconnectivity, with widespread fMRI hyperconnectivity juvenile mice reconfiguring hippocampal hypoconnectivity over puberty. These correlated alterations dendritic spine density, both were transiently normalized by GSK3β inhibition, suggesting synaptic origin this phenomenon. Notably, analogous pubertal hyperconnectivity-to-hypoconnectivity reconfiguration occurs human affecting cortical regions enriched GSK3β-associated genes autism-relevant transcripts. This also predicts age-dependent social 22q11DS individuals. results suggest that mechanisms underlie

Language: Английский

Citations

0