Long COVID, the Brain, Nerves, and Cognitive Function

Neurology International, Journal Year: 2023, Volume and Issue: 15(3), P. 821 - 841

Published: July 6, 2023

SARS-CoV-2, a single-stranded RNA coronavirus, causes an illness known as coronavirus disease 2019 (COVID-19). Long-term complications are increasing issue in patients who have been infected with COVID-19 and may be result of viral-associated systemic central nervous system inflammation or arise from virus-induced hypercoagulable state. incite changes brain function wide range lingering symptoms. Patients often experience fatigue note fog, sensorimotor symptoms, sleep disturbances. Prolonged neurological neuropsychiatric symptoms prevalent can interfere substantially everyday life, leading to massive public health concern. The mechanistic pathways by which SARS-CoV-2 infection sequelae important subject ongoing research. Inflammation- induced blood-brain barrier permeability viral neuro-invasion direct nerve damage involved. Though the mechanisms uncertain, resulting documented numerous patient reports studies. This review examines constellation spectrum seen long COVID incorporates information on prevalence these contributing factors, typical course. Although treatment options generally lacking, potential therapeutic approaches for alleviating improving quality life explored.

Language: Английский

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The Lancet Psychiatry Commission: transforming mental health implementation research

The Lancet Psychiatry, Journal Year: 2024, Volume and Issue: 11(5), P. 368 - 396

Published: March 26, 2024

Language: Английский

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Links between COVID-19 and Alzheimer’s Disease—What Do We Already Know?

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(3), P. 2146 - 2146

Published: Jan. 25, 2023

Alzheimer’s disease (AD) is a life-changing condition whose etiology explained by several hypotheses. Recently, new virus contributed to the evidence of viral involvement in AD: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19 disease. AD was found be one most common comorbidities, and it increase mortality from this as well. Moreover, patients were observed present with distinct clinical features COVID-19, delirium being prevalent group. The SARS-CoV-2 enters host cells through angiotensin-converting enzyme (ACE2) receptor. ACE2 overexpressed brains AD, thus increases invasion. Furthermore, inhibition receptor may also decrease brain-derived neurotrophic factor (BDNF), contributing neurodegeneration. ApoE ε4 allele, risk facilitate entry into cells. neuroinflammation oxidative stress existing enhance inflammatory response associated COVID-19. pandemic social distancing measures negatively affected mental health, cognitive function, neuro-psychiatric symptoms patients. This review comprehensively covers links between disease, including presentation, molecular mechanisms, effects distancing.

Language: Английский

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Prevalence of depressive symptoms in U.S. adults during the COVID-19 pandemic: A systematic review

SSM - Population Health, Journal Year: 2023, Volume and Issue: 21, P. 101348 - 101348

Published: Jan. 28, 2023

The COVID-19 pandemic has led to a worsening of mental health among U.S. adults. However, no review date synthesized the overall prevalence population depressive symptoms in over pandemic. We aimed document and psychological distress across time since start pandemic, both identify patterns that emerged literature assess data sources, methods, sampling, measurement used examine during In systematic peer literature, we identified 49 articles reporting 88 points related constructs nationally representative samples adults from March 2020 June 2021. First, found average poor studies was 12.9% for severe depression, 26.0% at least moderate 36.0% mild depression. Second, women reported significantly higher probable depression than men 63% levels by gender results on statistically significant differences between racial ethnic groups were mixed. Third, published based 12 studies; most common sources Household Pulse Survey (n = 15, 31%), AmeriSpeak panel 8, 16%), Qualtrics Understanding America Study 5, 10%). Prevalence estimates varied screening instruments cutoffs used. commonly Patient Health Questionnaire (PHQ) 36, 73%) Kessler 16%) series. While depending survey instruments, severity, reported, remained high through 2021 severity. scope can help policymakers providers address prepare meet ongoing future needs post-COVID-19 context beyond.

Language: Английский

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Physical activity and sedentary behaviour-specific domains and their associations with mental health in adults: a systematic review

Advances in Mental Health, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 28

Published: March 8, 2024

Objective The relationship of specific domains physical activity (PA) and sedentary behaviour (SB) (i.e. leisure, work, home, transportation) with mental health/illness is still unclear. Thus, we systematically gathered the evidence that examined between PA SB measures in adults.

Language: Английский

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Struggling, Forgotten, and Under Pressure: A Scoping Review of Experiences of Sex Workers During the COVID-19 Pandemic

Archives of Sexual Behavior, Journal Year: 2023, Volume and Issue: 52(5), P. 1969 - 2010

Published: June 13, 2023

The COVID-19 pandemic profoundly affected physical, mental, and economic well-being across the globe has disproportionately certain vulnerable groups. This paper provides a scoping review of literature on impact sex workers, published between December 2019 2022. Six databases were systematically searched, identifying 1009 citations; 63 studies included in review. Thematic analysis revealed eight main themes: financial issues; exposure to harm; alternate ways working; knowledge, protective behaviors, fear, risk; well-being, mental health, coping; access support; health care; research with workers. COVID-associated restrictions led reduced work income, leaving many workers struggling cover basic needs; additionally, government protections excluded those working informal economy. Fearing loss their already number clients, felt compelled compromise both prices measures. Although some engaged online work, this raised concerns about visibility was impossible for without technological or skills. Many feared COVID-19, but pressure continue working, often clients who refused wear masks share history. Other negative impacts related support care. Marginalized populations (and especially professions which require close contact like workers) need further capacity-building within community recover from COVID-19.

Language: Английский

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Natural environments, psychosocial health, and health behaviors in a crisis – A scoping review of the literature in the COVID-19 context

Journal of Environmental Psychology, Journal Year: 2023, Volume and Issue: 88, P. 102009 - 102009

Published: April 9, 2023

The COVID-19 outbreak led to major restrictions globally, affecting people's psychosocial health and their behaviors. Thus, the purpose of this scoping review was summarize available research regarding nature in context. Keywords relating natural environments were combined conduct a systematic online search six databases. Eligibility criteria a) published since 2020 with data collected context b) peer-reviewed, c) original empirical on human participants, d) investigated association between or behaviors, e) English, German, Scandinavian languages. Out 9126 articles being screened, we identified 188 relevant articles, representing 187 distinct studies. Most focused adults general population predominantly conducted USA, Europe, China. Overall, findings indicate that may mitigate impact psychological physical activity. Through thematic analysis extracted data, three primary themes identified: 1) type assessed, 2) behaviors investigated, 3) heterogeneity nature–health relationship. Research gaps I) characteristics promote II) investigations digital virtual nature, III) constructs mental promotion, IV) health-promoting other than activity, V) underlying mechanisms relationship based human, geographic characteristics, VI) focusing vulnerable groups. demonstrate considerable potential buffering stressful events level health. However, future is warranted fill mentioned examine long-term effects exposure during COVID-19.

Language: Английский

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Health-related quality of life in persons post-COVID-19 infection in comparison to normative controls and chronic pain patients

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Oct. 20, 2022

The Coronavirus disease 2019 (COVID-19) pandemic exerted a tremendous pressure on the healthcare system, people's social life, mental health and financial status with profound implications for general population. exact impact of overall physical, wellbeing COVID-19 infection survivors long term has not yet been explored in thorough way. Based reporting persistent pain, fatigue dyspnea symptoms by these survivors, it is our hypothesis that their quality life will be extremely impacted, as observed patients chronic pain. Therefore, first aim this study was to perform an in-depth evaluation post-COVID-19 infected persons. second compare persons normative population Health-related measure person's mental, wellbeing, measured 3-level EQ5D 547 These data were compared reference from normal records Belgium pain after spinal surgery two-way analyses variance. In total, 89.58% reported pain/discomfort 82.45% indicated limitations when performing usual activities, evaluated 287 days (SD: 150) infection. Self-care preserved most persons, whereby only 13.16% problems. mean EQ5D-3L index score 0.57 0.23) VAS 56.6 18.2). significantly higher than [mean difference 0.31 (95% 0.29 0.33), p < 0.01] while lower −0.31 −0.29 −0.33), 0.01]. Compared age-and sex adjusted data, health-related COVID severely impacted. relation surgery, seemed better. Clinical trial registration https://www.clinicaltrials.gov/ , identifier: NCT04912778.

Language: Английский

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Attitudes towards booster, testing and isolation, and their impact on COVID-19 response in winter 2022/2023 in France, Belgium, and Italy: a cross-sectional survey and modelling study

The Lancet Regional Health - Europe, Journal Year: 2023, Volume and Issue: 28, P. 100614 - 100614

Published: March 23, 2023

European countries are focusing on testing, isolation, and boosting strategies to counter the 2022/2023 winter surge due SARS-CoV-2 Omicron subvariants. However, widespread pandemic fatigue limited compliance potentially undermine mitigation efforts.To establish a baseline for interventions, we ran multicountry survey assess respondents' willingness receive booster vaccination comply with testing isolation mandates. Integrating estimated immunity data in branching process epidemic spreading model, evaluated effectiveness costs of current protocols France, Belgium, Italy manage wave.The vast majority participants (N = 4594) was willing adhere (>91%) rapid (>88%) across three countries. Pronounced differences emerged declared senior adherence (73% 94% 86% Italy). Epidemic model results estimate that would confer significant benefit reducing transmission (17-24% reduction, from R 1.6 1.3 France 1.2 Italy) adherence. Achieving mitigating level similar French protocol, Belgian protocol require 35% fewer tests (from 1 test 0.65 per infected person) avoid long periods Italian (average 6 days vs. 11). A cost barrier significantly decrease undermining protocols' effectiveness.Simpler mandates may increase awareness actual compliance, costs, without compromising mitigation. High uptake remains key control Commission, ANRS-Maladies Infectieuses Émergentes, Agence Nationale de la Recherche, Chaires Blaise Pascal Program Île-de-France region.

Language: Английский

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Addressing mental health need after COVID-19: a systematic review of remote EMDR therapy studies as an emerging option

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 4, 2024

Introduction The COVID-19 pandemic has been associated with a substantial rise in mental health challenges, prompting need for accessible and effective therapeutic interventions. This review summarizes the evidence on remote Eye Movement Desensitization Reprocessing (EMDR) therapy delivered response to increased need. Methods A systematic was conducted following Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines. Databases including PsychINFO, EMBASE, MEDLINE, Web of Science were searched identify studies assessing efficacy EMDR administered online. Results Sixteen articles meeting inclusion criteria selected, involving 1,231 participants across various age groups. Studies covered individual group sessions self-administered computerized protocols. Findings indicate promising outcomes reducing PTSD symptoms, anxiety, depression. Discussion analysis selected demonstrates feasibility potential online as an option addressing difficulties, particularly during times limited in-person interaction. However, revealed limitations such small sample sizes, absence control groups, reliance self-reported measures. registration: present registered “The International Database Register Your Reviews” (INPLASY) registration number 2023120018 DOI 10.37766/inplasy2023.2.0068 .

Language: Английский

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