Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 18, 2024
Photoagents
with
ultra-high
near-infrared
II
(NIR-II)
light
energy
conversion
efficiency
hold
great
promise
in
tumor
phototherapy
due
to
their
ability
penetrate
deeper
tissues
and
minimize
damage
surrounding
healthy
cells.
However,
the
development
of
NIR-II
photoagents
remain
challenging.
In
this
study,
an
all-fused-ring
quinoidal
acceptor-donor-acceptor
(A-D-A)
molecule,
SKCN,
a
BTP
core
is
synthesized,
nanoparticles
named
FA-SNPs
are
prepared.
The
unique
structure
enhances
π-electron
delocalization
bond
length
uniformity,
significantly
reducing
bandgap
resulting
strong
absorption,
high
molar
extinction
coefficient,
photothermal
75.14%.
Enhanced
molecular
rigidity
also
facilitates
efficient
transfer
oxygen,
boosting
reactive
oxygen
species
generation.
By
incorporating
immunomodulator
R848,
FA-SRNPs
further
developed,
effectively
modulating
immune
microenvironment
by
Tregs
M-MDSCs
infiltration,
promoting
dendritic
cell
maturation,
M1
macrophage
polarization,
activating
CD8+
T
cells
NK
Comprehensive
studies
using
orthotopic
ovarian
cancer
models
demonstrated
targeting,
photoacoustic
imaging
capabilities,
significant
suppression
metastasis
inhibition,
showing
excellent
therapeutic
efficacy
breast
model.
This
study
provides
evidence
for
potential
application
A-D-A
molecules
photoimmunotherapy.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(49)
Published: Oct. 20, 2023
Abstract
Two
exotic
6‐cantilever
small
molecular
platforms,
characteristic
of
quite
different
configurations
propeller
and
quasi‐plane,
are
established
by
extremely
two‐dimensional
conjugated
extension.
When
applied
in
acceptors,
the
only
two
cases
CH25
CH26
that
could
contain
six
terminals
such
broad
backbones
have
been
afforded
thus
far,
rendering
featured
absorptions,
reorganization
exciton
binding
energies.
Moreover,
their
distinctive
but
completely
geometries
result
sharply
contrasting
nanoscale
film
morphologies.
Finally,
contributes
to
best
device
efficiency
15.41
%
among
acceptors
with
terminals,
demonstrating
pioneered
yet
highly
promising
innovation
platforms.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 8, 2024
Abstract
Given
homomorphic
fluorine
(F),
chlorine
(Cl)
and
bromine
(Br)
atoms
are
featured
with
gradually
enlarged
polarizability/atomic
radius
but
decreased
electronegativity,
the
rational
screen
of
halogen
species
locations
on
small
molecular
acceptors
(SMAs)
is
quite
essential
for
acquiring
desirable
packing
to
boost
efficiency
organic
solar
cells
(OSCs).
Herein,
three
isomeric
SMAs
(CH−F,
CH−C
CH−B)
constructed
by
delicately
rebuilding
peripheral
F,
Cl,
Br
footprints
both
central
end
units.
Such
a
re‐permutation
halogens
could
not
only
maintain
structural
symmetry
maximum,
also
acquire
extra
asymmetric
benefits
enhanced
dipole
moment
intramolecular
charge
transfer,
etc.
Moreover,
brominating
enhances
crystallinity
CH−B
without
introducing
undesirable
steric
hindrance
groups,
thus
rendering
better
balance
between
high
crystallization
domain
size
control
in
PM6:CH−B
blend.
Further
benefitting
from
large
dielectric
constant,
exciton
binding
energy,
optimized
great
electron
transfer
integral,
affords
first
class
binary
OSC
19.78
%,
moreover,
highest
18.35
%
far
when
increasing
active
layer
thickness
~300
nm.
Our
successful
screening
provides
valuable
insight
into
further
design
record‐breaking
OSCs.
ACS Energy Letters,
Journal Year:
2024,
Volume and Issue:
9(11), P. 5541 - 5549
Published: Oct. 25, 2024
The
efficiencies
of
dimer-based
devices
still
lag
those
their
small
molecule-based
counterparts.
This
is
primarily
due
to
the
considerable
dihedrals
in
dimer
skeleton,
which
compromises
molecular
packing,
thus
influencing
charge
generation
and
nonradiative
voltage
loss
(ΔVoc,nr).
Herein,
we
developed
two
dimeric
acceptors
with
varied
π-linkers
investigate
influence
linker-induced
conformational
lock
on
ΔVoc,nr.
We
find
that
helically
lapped
O-shaped
delivers
better
intermolecular
packing
than
planar
S-shaped
one
incorporates
a
bulkier
π-linker.
However,
its
skeleton
instead
more
favorable
for
forming
compact
ordered
stacking
host
acceptor
ternary
blend.
possibly
promotes
exciton
dissociation,
reducing
decay
excited
states.
Moreover,
longer
lifetime
could
offer
additional
charge-transfer
channels.
These
contributions
effectively
minimize
ΔVoc,nr
0.195
eV,
while
delivering
high
efficiency
approaching
20%
derived
device.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 18, 2024
Photoagents
with
ultra-high
near-infrared
II
(NIR-II)
light
energy
conversion
efficiency
hold
great
promise
in
tumor
phototherapy
due
to
their
ability
penetrate
deeper
tissues
and
minimize
damage
surrounding
healthy
cells.
However,
the
development
of
NIR-II
photoagents
remain
challenging.
In
this
study,
an
all-fused-ring
quinoidal
acceptor-donor-acceptor
(A-D-A)
molecule,
SKCN,
a
BTP
core
is
synthesized,
nanoparticles
named
FA-SNPs
are
prepared.
The
unique
structure
enhances
π-electron
delocalization
bond
length
uniformity,
significantly
reducing
bandgap
resulting
strong
absorption,
high
molar
extinction
coefficient,
photothermal
75.14%.
Enhanced
molecular
rigidity
also
facilitates
efficient
transfer
oxygen,
boosting
reactive
oxygen
species
generation.
By
incorporating
immunomodulator
R848,
FA-SRNPs
further
developed,
effectively
modulating
immune
microenvironment
by
Tregs
M-MDSCs
infiltration,
promoting
dendritic
cell
maturation,
M1
macrophage
polarization,
activating
CD8+
T
cells
NK
Comprehensive
studies
using
orthotopic
ovarian
cancer
models
demonstrated
targeting,
photoacoustic
imaging
capabilities,
significant
suppression
metastasis
inhibition,
showing
excellent
therapeutic
efficacy
breast
model.
This
study
provides
evidence
for
potential
application
A-D-A
molecules
photoimmunotherapy.
