Aggregation-Induced Emission Luminogens Realizing High-Contrast Bioimaging

ACS Nano, Journal Year: 2025, Volume and Issue: 19(1), P. 281 - 306

Published: Jan. 2, 2025

A revolutionary transformation in biomedical imaging is unfolding with the advent of aggregation-induced emission luminogens (AIEgens). These cutting-edge molecules not only overcome limitations traditional fluorescent probes but also improve boundaries high-contrast imaging. Unlike conventional fluorophores suffering from aggregation-caused quenching, AIEgens exhibit enhanced luminescence when aggregated, enabling superior performance. This review delves into molecular mechanisms (AIE), demonstrating how strategic design unlocks exceptional and contrast, which crucial for distinguishing healthy diseased tissues. highlights key applications AIEgens, such as time-resolved imaging, second near-infrared window (NIR-II), advancement sensitivity to physical biochemical cue-responsive The development AIE technology promises transform healthcare early disease detection targeted therapies, potentially reshaping personalized medicine. paradigm shift biophotonics offers efficient tools decode complexities biological systems at level, bringing us closer a future where invisible becomes visible incurable treatable.

Language: Английский

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Integration of Motion and Stillness: A Paradigm Shift in Constructing Nearly Planar NIR-II AIEgen with Ultrahigh Molar Absorptivity and Photothermal Effect for Multimodal Phototheranostics

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The two contradictory entities in nature often follow the principle of unity opposites, leading to optimal overall performance. Particularly, aggregation-induced emission luminogens (AIEgens) with donor–acceptor (D–A) structures exhibit tunable optical properties and versatile functionalities, offering significant potential revolutionize cancer treatment. However, trapped by low molar absorptivity (ε) owing distorted configurations, ceilings their photon-harvesting capability corresponding phototheranostic performance still fall short. Therefore, a research paradigm from twisted configuration near-planar structure featuring high ε is urgently needed for AIEgens development. Herein, introducing strategy "motion stillness" into highly planar A–D–A skeleton, we successfully developed near-infrared (NIR)-II AIEgen Y5-2BO-2BTF, which boasts an impressive 1.06 × 105 M–1 cm–1 photothermal conversion efficiency (PCE) 77.8%. modification steric hindrance on benzene ring acceptor unit aggregation-caused quenching counterpart Y5-2BO, meta-CF3-substituted naphthyl, leads reversely staggered packing various intermolecular noncovalent conformational locks Y5-2BO-2BTF ("stillness"). Furthermore, −CF3 moiety acted as flexible motion ultralow energy barrier, significantly facilitating process loose aggregates ("motion"). Accordingly, nanoparticles enabled tumor eradication pulmonary metastasis inhibition through NIR-II fluorescence-photoacoustic-photothermal imaging-navigated type I photodynamic-photothermal therapy. This work provides first evidence that conformation stacking arrangement could serve novel molecular design direction AIEgens, shedding new light constructing superior agents bioimaging

Language: Английский

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Achieving Near‐Infrared Phosphorescence Supramolecular Hydrogel Based on Amphiphilic Bromonaphthalimide Pyridinium Hierarchical Assembly

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

Abstract Phosphorescent supramolecular hydrogels are currently a prevalent topic for their great promise in various photonic applications. Herein, an efficient near‐infrared (NIR) phosphorescence hydrogel is reported via the hierarchical assembly strategy aqueous solution, which fabricated from amphiphilic bromonaphthalimide pyridinium derivative (G), exfoliated Laponite (LP) nanosheets, and polymeric polyacrylamide (PAAm). Initially, G spontaneously self‐aggregates into spherical nanoparticles covered with positively charged units emits single fluorescence at 410 nm. Driven by electrostatic interactions negatively subsequently function as cross‐linked binders coassemble LP engendered red room‐temperature (RTP) up to 620 Benefiting hydrogen‐bonding interactions‐mediated physical cross‐linkage, further introduction of PAAm not only significantly elevates mechanical strength showing fast self‐healing capability, but also increases lifetime 2.49 4.20 ms, especially generating even higher temperature ( τ 363 K = 2.46 ms). Additionally, RTP energy transfer occurs after doping small amount organic dye heptamethine cyanine (IR780) acceptor hydrogels, resulting long‐lived NIR emission 823 nm high donor/acceptor ratio, successfully applied cell labeling window.

Language: Английский

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Pure Organic Thermally Activated Delayed Fluorescence Afterglow Polymers via Dopant Isomerization

ACS Macro Letters, Journal Year: 2025, Volume and Issue: unknown, P. 265 - 271

Published: Feb. 13, 2025

N-(o-Cyanophenyl)carbazole can be dimerized at different positions, which may change excited state behaviors. Herein, 2,3′-dicyano-3,4′-di(carbazol-9-yl)biphenyl (D34C) is designed and synthesized doped into polymers. However, we find that D34C does not exhibit room temperature phosphorescence but emits fluorescence (FL) bright thermally activated delayed (TADF) with lifetimes of hundreds milliseconds, observed in diverse matrices such as PMMA, MBS, ABS, PS, HIPS, SIS. The simple positional isomerization makes the abundant triplet excitons undergo only reverse intersystem crossing rather than (RTP) radiation, rare organic Since production TADF afterglow requires a certain excitation time, generally indistinguishable FL efficiencies are separated for first time. This work provides novel polymers mechanical properties also will evoke subtle design conjugated molecules to dramatically photoexcitation emission

Language: Английский

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Nanophotonic-enhanced photoacoustic imaging for brain tumor detection

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 5, 2025

Photoacoustic brain imaging (PABI) has emerged as a promising biomedical modality, combining high contrast of optical with deep tissue penetration ultrasound imaging. This review explores the application photoacoustic in tumor imaging, highlighting synergy between nanomaterials and state art techniques to achieve high-resolution deeper tissues. PABI leverages effect, where absorbed light energy causes thermoelastic expansion, generating waves that are detected converted into images. technique enables precise diagnosis, therapy monitoring, enhanced clinical screening, specifically management complex diseases such breast cancer, lymphatic disorder, neurological conditions. Despite integration agents radiation, providing comprehensive overview current methodologies, major obstacles treatment, future directions for improving diagnostic therapeutic outcomes. The underscores significance robust research tool medical method, potential revolutionize disease diagnosis treatment.

Language: Английский

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Narrowband Emissive Solution‐Processed Polymer Organic Light‐Emitting Diodes with External Quantum Efficiency Above 30%

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract Achieving both high‐efficiency and narrowband emission in thermally activated delayed fluorescence (TADF) polymers remains a formidable challenge. In this work, proof of concept for narrowband‐emissive TADF with partially conjugated structure is proposed by embedding silicon─carbon σ‐bond saturated spacer between the multiresonance (MR) unit polycarbazole backbone. A series PSix ( x = 1, 3, 6) then prepared characterized. All show full width at half maximum (FWHM) values 28–30 nm toluene solution. Impressively, polymer PSi3 has highest photoluminescence quantum yield, reaching 97%, doped films due to efficient reverse intersystem crossing process. The solution‐processed devices based on exhibit best performance external efficiency EQE max ) 28.8% an FWHM 42 nm. By employing molecule 5Cz‐TRZ as sensitizer, enhanced device 30.2% achieved, which first tier among MR‐TADF reported date. This work provides effective strategy achieving highly controlling chromophore

Language: Английский

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Stimulus‐Responsive Emission via Dynamic Triplet Energy Transfer in Organic Room‐Temperature Phosphorescence Glass

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Dynamic organic room‐temperature phosphorescence (RTP) glasses with color tunability offer significant potential for practical applications due to their high transparency and excellent machinability. In this study, efficient dynamic RTP properties are used as triplet donors, combined commercially available chromophores singlet/triplet acceptors, successfully fabricate a series of host‐guest doping color‐tunable afterglow responses external stimuli. The energy transfer mechanisms, including triplet‐to‐singlet resonance Dexter‐type triplet‐to‐triplet transfer, confirmed using state‐of‐the‐art femtosecond time‐resolved transient absorption spectroscopy. These demonstrate transparency, good machinability, responsiveness study highlights in large‐area glass fabrication, data encryption, flexible displays. This work not only provides simple design principle developing novel materials but also promotes the information encryption optoelectronics.

Language: Английский

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Heteroatomic multiple bonded corrosion inhibitors: Coordination chemistry, bonding and synergistic behavior of σ-donors and π-acceptors

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 537, P. 216683 - 216683

Published: April 15, 2025

Language: Английский

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Positional Effects of Fluorine Substitution on Room Temperature Phosphorescence in Hexaphenylmelamine Derivatives

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 49(3), P. 674 - 678

Published: Dec. 13, 2024

Three fluorine-substituted hexaphenylmelamine phosphors were synthesized, and the positional effects of fluorine substitution on their RTP behaviors systematically investigated.

Language: Английский

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Electrochemical and Optical Properties of D-A-A-A-D Azomethine Triad and Its NIR-Active Polymer

Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4470 - 4470

Published: Sept. 20, 2024

The azomethine TPA-(BTZ)3-TPA with a donor–acceptor–acceptor–acceptor–donor structure has been synthesized and characterized. Azomethine exhibited luminescence properties positive solvatochromic effect. Electropolymerization on terminated triphenylamine groups was used to obtain thin layer of the polyazomethine poly-[TPA-(BTZ)3-TPA]. Further investigation oxidation/reduction poly-[TPA-(BTZ)3-TPA] via cyclic voltammetry showed that polymer undergoes two reversible processes due presence tetraphenylbenzidine moieties. Electrochromic were investigated spectroelectrochemistry. It observed in its neutral state is orange, color changes green upon electro-oxidation. stability during multiple cycles, response times, coloration efficiency also investigated.

Language: Английский

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