Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Photodynamic
therapy
(PDT)
is
a
clinically
approved
therapeutic
modality
that
has
shown
great
potential
for
cancer
treatment.
However,
there
exist
two
major
problems
hindering
PDT
applications:
the
nonspecific
phototoxicity
requiring
patients
to
stay
in
dark
post-PDT,
and
limited
photodynamic
efficiency.
Herein,
we
report
photo-triggered
porphyrin
polyelectrolyte
nanoassembling
(photo-triggered
PPN)
strategy,
which
photosensitizer
photoswitchable
energy
accepter
are
assembled
into
micelles
by
combined
force
of
charge
interaction
metal-ligand
coordination.
The
polyelectrolyte-based
PPN
exhibits
good
biocompatibility,
bestows
unique
"confining
isolated"
inner
microenvironment
fully
overcoming
π-π
stacking
porphyrins
with
significant
efficiency
(123-fold
enhancement).
Due
high
Förster
resonance
transfer
(FRET)
(91.5
%)
between
photoswitch
closed-form,
could
use
light
as
specific
trigger
modulate
closed-
open-form,
manipulate
Chemical & Biomedical Imaging,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
A
variety
of
bioorthogonal
chemical
tools
have
been
developed
and
widely
used
in
the
study
biological
phenomena
situ.
Tetrazine
chemistry
exhibits
ultrafast
reaction
kinetics,
excellent
biocompatibility,
precise
optical
regulatory
capabilities.
Fluorogenic
tetrazine
probes
achieved
particularly
diverse
applications
bioimaging
disease
diagnosis
treatment.
This
Viewpoint
briefly
introduces
characteristics
advantages
chemistry,
some
design
strategies
fluorogenic
probes,
status
these
to
vivo
imaging,
as
well
Finally,
we
discuss
challenges
propose
future
trends
field
probes.
offers
insights
into
development
new
for
biology
research
drugs.
Smart Molecules,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 24, 2024
Abstract
In
vivo
optical
imaging
has
become
an
invaluable
tool
for
visualizing
and
monitoring
biological
processes
in
living
organisms.
A
key
component
of
these
techniques
is
the
use
fluorescent
dyes
that
can
selectively
target
label
specific
tissues
or
cell
types.
This
review
provides
overview
current
state
tissue‐seeking
applications.
We
discuss
design
principles
chemical
structures
have
been
developed
to
various
interest,
including
tumors,
nerves,
bones,
vasculatures,
other
tissues.
The
covers
photophysical
properties,
targeting
mechanisms,
performance
dyes.
Particular
emphasis
placed
on
demonstrated
clinical
translation
high
potential
future
use.
also
examines
challenges
considerations
developing
effective
dyes,
such
as
achieving
specificity,
overcoming
barriers
minimizing
toxicity.
Finally,
we
highlight
emerging
trends
directions
field,
integration
with
advanced
modalities
theranostic
Overall,
this
a
focused
summary
landscape
their
pivotal
role
advancing
its
biomedical
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Abstract
Photodynamic
therapy
(PDT)
is
a
clinically
approved
therapeutic
modality
that
has
shown
great
potential
for
cancer
treatment.
However,
there
exist
two
major
problems
hindering
PDT
applications:
the
nonspecific
phototoxicity
requiring
patients
to
stay
in
dark
post‐PDT,
and
limited
photodynamic
efficiency.
Herein,
we
report
photo‐triggered
porphyrin
polyelectrolyte
nanoassembling
(photo‐triggered
PPN)
strategy,
which
photosensitizer
photoswitchable
energy
accepter
are
assembled
into
micelles
by
combined
force
of
charge
interaction
metal‐ligand
coordination.
The
polyelectrolyte‐based
PPN
exhibits
good
biocompatibility,
bestows
unique
“confining
isolated”
inner
microenvironment
fully
overcoming
π–π
stacking
porphyrins
with
significant
efficiency
(123‐fold
enhancement).
Due
high
Förster
resonance
transfer
(FRET)
(91.5
%)
between
photoswitch
closed‐form,
could
use
light
as
specific
trigger
modulate
closed‐
open‐form,
manipulate
1
O
2
generation
three
stages:
pre‐PDT
(quenching
generation),
during
(activating
post‐PDT
(silencing
generation).
This
de
novo
strategy
first
time
realized
remotely
manipulating
boosting
PDT,
well
resolving
critical
general
challenges
side
effects
from
phototoxicity.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Photodynamic
therapy
(PDT)
is
a
clinically
approved
therapeutic
modality
that
has
shown
great
potential
for
cancer
treatment.
However,
there
exist
two
major
problems
hindering
PDT
applications:
the
nonspecific
phototoxicity
requiring
patients
to
stay
in
dark
post-PDT,
and
limited
photodynamic
efficiency.
Herein,
we
report
photo-triggered
porphyrin
polyelectrolyte
nanoassembling
(photo-triggered
PPN)
strategy,
which
photosensitizer
photoswitchable
energy
accepter
are
assembled
into
micelles
by
combined
force
of
charge
interaction
metal-ligand
coordination.
The
polyelectrolyte-based
PPN
exhibits
good
biocompatibility,
bestows
unique
"confining
isolated"
inner
microenvironment
fully
overcoming
π-π
stacking
porphyrins
with
significant
efficiency
(123-fold
enhancement).
Due
high
Förster
resonance
transfer
(FRET)
(91.5
%)
between
photoswitch
closed-form,
could
use
light
as
specific
trigger
modulate
closed-
open-form,
manipulate
