Carbon quantum dots: Preparation, optical properties, and biomedical applications

Materials Today Advances, Journal Year: 2023, Volume and Issue: 18, P. 100376 - 100376

Published: May 3, 2023

As an excellent fluorescent nanomaterial, carbon quantum dots (CQDs) have the properties of small molecular weight, particle size, high fluorescence stability, no optical flicker, wide excitation spectrum, continuous, long adjustable emission wavelength, good biocompatibility and low toxicity. At present, it has been widely used in biological detection, vivo vitro imaging, drug delivery diagnostic drugs. This review presents a broad overview recent progress synthesis, properties, biomedical applications CQDs. The synthesis methods CQDs are first introduced, followed by extensive discussion its purification, surface functionalization stability. Furthermore, presented, with emphasis on photoluminescence mechanism relationship between conditions properties. review's much focus is given to CQDs, including imaging (in imaging) (targeted therapy, photodynamic photothermal immunological gene therapy). Finally, we cover key issues future prospects/advances that still deal sector as well possible solutions.

Language: Английский

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Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(18), P. 11047 - 11136

Published: Sept. 7, 2023

Advances in nanotechnology and nanomaterials have attracted considerable interest play key roles scientific innovations diverse fields. In particular, increased attention has been focused on carbon-based exhibiting extended structures unique properties. Among these materials, zero-dimensional structures, including fullerenes, carbon nano-onions, nanodiamonds, dots, possess excellent bioaffinities superior fluorescence properties that make suitable for application to environmental biological sensing, imaging, therapeutics. This review provides a systematic overview of the classification structural properties, design principles preparation methods, optical sensing applications nanomaterials. Recent interesting breakthroughs sensitive selective imaging heavy metal pollutants, hazardous substances, bioactive molecules as well information encryption, super-resolution photoacoustic phototherapy nanomedicine delivery are main focus this review. Finally, future challenges prospects materials highlighted envisaged. presents comprehensive basis directions designing, developing, applying fascinating fluorescent sensors fabricated based specific requirements numerous research

Language: Английский

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Multifunctional Fe-doped carbon dots and metal-organic frameworks nanoreactor for cascade degradation and detection of organophosphorus pesticides

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 464, P. 142480 - 142480

Published: March 17, 2023

Language: Английский

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Multifunctional Carbon Dots for Biomedical Applications: Diagnosis, Therapy, and Theranostic

Small, Journal Year: 2023, Volume and Issue: 20(3)

Published: Sept. 13, 2023

Abstract Designing suitable nanomaterials is an ideal strategy to enable early diagnosis and effective treatment of diseases. Carbon dots (CDs) are luminescent carbonaceous nanoparticles that have attracted considerable attention. Through facile synthesis, they process properties including tunable light emission, low toxicity, energy transformation, leading diverse applications as optically functional materials in biomedical fields. Recently, their potentials been further explored, such enzyme‐like activity ability promote osteogenic differentiation. refined synthesizing strategies carbon dots, a rich treasure trove for new discoveries, stand chance guide significant development applications. In this review, the authors start with brief introduction CDs. By presenting mechanisms examples, focus on how can be used diagnosing treating diseases, bioimaging failure tissues cells, biosensing various pathogenic factors biomarkers, tissue defect repair, anti‐inflammation, antibacterial antiviral, novel oncology treatment. The application integrated follows closely behind. Furthermore, challenges future directions CDs discussed. hope review will provide critical perspectives inspire discoveries prompt advances

Language: Английский

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Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo

ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 3916 - 3968

Published: Jan. 23, 2024

Dynamic variations in the concentration and abnormal distribution of endogenous biomarkers are strongly associated with multiple physiological pathological states. Therefore, it is crucial to design imaging systems capable real-time detection dynamic changes for accurate diagnosis effective treatment diseases. Recently, ratiometric has emerged as a widely used technique sensing due its advantage circumventing limitations inherent conventional intensity-dependent signal readout methods while also providing built-in self-calibration correction. Here, recent progress probes their applications outlined. Ratiometric classified according mechanisms, photoacoustic imaging, optical including photoluminescence self-luminescence magnetic resonance dual-modal discussed. The such pH, reactive oxygen species (ROS), nitrogen (RNS), glutathione (GSH), gas molecules, enzymes, metal ions, hypoxia discussed detail. Additionally, this Review presents an overview challenges faced field along future research directions.

Language: Английский

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Carbon Dots for Intracellular Sensing

Small Structures, Journal Year: 2022, Volume and Issue: 3(9)

Published: June 15, 2022

Carbon dots (CDs), a type of small, carbon element‐based nanomaterials, have found numerous applications in many fields due to their outstanding properties like fascinating photoluminescence characteristic, great biocompatibility, easy and economical synthesis, facile functionalization. Over the last decade, huge progress achievements been made terms CDs cellular detection. However, comprehensive review focusing on this topic is still lacking. Herein, recent CDs‐mediated intracellular detection, including fluorescence imaging structures (e.g., nucleus/nucleolus, mitochondrion, lysosome, endoplasmic reticulum, Golgi apparatus, lipid droplet), detection large variety substances (including endogenous biomacromolecules monomers, vitamins, important metabolites, adenosine triphosphate, reactive oxygen species, biothiols, ions, exogenous compounds), monitoring parameters (pH, temperature, mitochondrial membrane potential), thoroughly reviewed. The functionalization, performance that serve as fluorescent nanoprobes living cells are presented. Their underlying working mechanisms also discussed if available. Finally, challenges future research directions related field listed. This may foster development more with better sensing performance.

Language: Английский

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Controlled Synthesis of Multicolor Carbon Dots Assisted by Machine Learning

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 33(2)

Published: Oct. 31, 2022

Abstract Carbon dots (CDs) have received extensive attention and applications in recent years due to their remarkable characteristics of tunable emission wavelength, high stability, a variety synthetic raw materials. Since the formation process photoluminescence properties CDs are affected by multiple factors, luminescence regulation has always been troublesome problem. Furthermore, it is still lack appropriate approaches reveal hidden rules between synthesis conditions CDs. Inspired machine learning (ML) molecular materials science, herein, data‐driven ML strategy proposed multi‐dimensionally investigate correlation reaction parameters Meanwhile, demonstrated that solvent different influences on fluorescence CDs, intelligently optimizing route achieved using algorithms. with excellent luminescent screened further applied high‐capacity colorful information encryption. This study provides an efficient ML‐assisted guide multicolor helping researchers quickly easily obtain according experimental requirements.

Language: Английский

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Recent research progress of fluorescence biosensors based on carbon dots in early diagnosis of diseases

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 180, P. 117962 - 117962

Published: Sept. 7, 2024

Language: Английский

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Machine learning-assisted three-dimensional fluorescence for heavy metal multi-sensing

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: 431, P. 137385 - 137385

Published: Feb. 7, 2025

Language: Английский

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Facile synthesis of multifunctional red-emissive carbon dots for fluorescent quercetin and pH sensing

Dyes and Pigments, Journal Year: 2022, Volume and Issue: 208, P. 110766 - 110766

Published: Sept. 24, 2022

Language: Английский

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