Small,
Journal Year:
2023,
Volume and Issue:
20(18)
Published: Dec. 10, 2023
Abstract
Graphene
solution‐gated
field‐effect
transistors
(gSGFETs)
offer
high
potential
for
chemical
and
biochemical
sensing
applications.
Among
the
current
trends
to
improve
this
technology,
functionalization
processes
are
gaining
relevance
its
crucial
impact
on
biosensing
performance.
Previous
efforts
focused
simplifying
attachment
procedure
from
standard
multi‐step
single‐step
strategies,
but
they
still
suffer
overreaction,
impurity
issues
limited
a
particular
ligand.
Herein,
novel
strategy
immobilization
of
chemically
modified
aptamers
with
fluorenylmethyl
acridine
moieties,
based
straightforward
synthetic
route
overcome
aforementioned
limitations
is
presented.
This
approach
benchmarked
versus
using
thrombin
as
detection
model.
In
order
assess
reliability
strategies
48‐gSGFETs
arrays
employed
acquire
large
datasets
multiple
replicas.
surface
characterization
demonstrates
robust
higher
efficiency
in
coupling
strategy,
while
electrical
response
evaluation
validates
capability,
allowing
implement
different
alternatives
data
analysis
reduce
variability.
work,
new
tool
capable
challenges
graphene
surfaces
provided,
paving
way
toward
standardization
gSGFETs
purposes.
Carbon,
Journal Year:
2024,
Volume and Issue:
223, P. 118970 - 118970
Published: Feb. 26, 2024
Hydrogel-integrated
graphene
superstructures
(GSSs)
represent
a
promising
platform
for
applications
in
tissue
engineering
and
regenerative
medicine.
Graphene,
two-dimensional
carbon-based
material,
possesses
remarkable
mechanical,
thermal,
electrical
characteristics,
making
it
strong
candidate
application
biomedicine.
Researchers
have
pursued
the
integration
of
with
hydrogels,
known
their
biocompatibility
ability
to
provide
conducive
environment
cellular
growth,
craft
sophisticated
scaffolds
tailored
needs.
The
hydrogels
enables
construction
3D
frameworks
that
closely
mimic
natural
extracellular
matrix
(ECM)
found
biological
tissues.
Hydrogels
furnish
biocompatible,
well-hydrated
environment,
while
component
bolsters
scaffold's
mechanical
integrity
conductivity.
This
amalgamation
enhances
adhesion,
differentiation,
proliferation,
thereby
facilitating
regeneration.
A
notable
advantage
hydrogel-integrated
GSSs
lies
capacity
support
growth
differentiation
variety
cell
types
such
as
PC12,
MG-63,
U-87,
MC3T3-E1
lines.
Overall,
exhibit
great
potential
advancing
biomimetic
combination
unique
properties
development
advanced
scaffold
systems
Further
research
this
domain
will
play
crucial
role
medicine
treatment
various
diseases
injuries.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 4, 2023
Promising
advances
in
molecular
medicine
have
promoted
the
urgent
requirement
for
reliable
and
sensitive
diagnostic
tools.
Electronic
biosensing
devices
based
on
field-effect
transistors
(FETs)
exhibit
a
wide
range
of
benefits,
including
rapid
label-free
detection,
high
sensitivity,
easy
operation,
capability
integration,
possessing
significant
potential
application
disease
screening
health
monitoring.
In
this
perspective,
tremendous
efforts
achievements
development
high-performance
FET
biosensors
past
decade
are
summarized,
with
emphasis
interface
engineering
FET-based
electrical
platforms
biomolecule
identification.
First,
an
overview
strategies
modulation
recognition
element
design
is
discussed
detail.
For
further
step,
applications
vitro
detection
real-time
monitoring
biological
systems
comprehensively
reviewed.
Finally,
key
opportunities
challenges
electronic
discussed.
It
anticipated
that
comprehensive
understanding
will
inspire
additional
techniques
developing
highly
sensitive,
specific,
stable
as
well
emerging
designs
next-generation
electronics.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(31)
Published: May 10, 2023
Abstract
Biomarkers
are
primary
indicators
for
precise
diagnosis
and
treatment.
The
early
identification
of
health
biomarkers
has
been
sustained
by
the
evolutionary
success
in
sensor
technologies.
Among
them,
graphene
field‐effect
transistor
(GFET)
biosensors
have
exhibited
major
advantages
such
as
an
ultrashort
response
time,
high
sensitivity,
easy
operation,
capability
integration,
label‐free
detection.
Owing
to
atomic
thickness,
restricts
charge
carrier
flow
merely
at
material
surface
responds
foreign
stimuli
directly,
leading
effective
signal
acquisition
transmission.
Here,
this
review
summarizes
latest
advances
GFET
a
comprehensive
manner
that
contains
device
design,
working
principle,
functionalization,
proof‐of‐concept
applications.
It
provides
survey
with
regard
biomarker
analysis
single‐device
level
integrated
prototypes
include
wearable
sensors,
biomimetic
systems,
healthcare
electronics,
diagnostic
platforms.
Moreover,
there
is
discussion
on
long‐standing
research
efforts
outlook
future
development
systems
from
lab
fab.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(35), P. 8577 - 8604
Published: Jan. 1, 2024
Biosensors
integrated
into
closed-loop
systems
provide
patient-specific
adaptive
therapies.
These
advanced
devices
have
significant
potential
for
managing
chronic
conditions
by
continuously
adjusting
therapeutic
regimens
based
on
physiological
data.
ACS Sensors,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
In
vivo
electrochemical
sensing
of
neurotransmitters,
neuromodulators,
and
metabolites
plays
a
critical
role
in
real-time
monitoring
various
physiological
or
psychological
processes
the
central
nervous
system.
Currently,
advanced
biosensors
technologies
have
been
emerging
as
prominent
ways
to
meet
surging
requirements
neurotransmitters
neuromodulators
ranging
from
single
cells
brain
slices,
even
entire
brain.
This
review
introduces
fundamental
working
principles
summarizes
achievements
biosensing
including
voltammetry,
amperometry,
potentiometry,
field-effect
transistor
(FET),
organic
(OECT).
According
elaborate
feature
technology,
versatile
strategies
devoted
solve
issues
associated
with
neurochemicals
under
an
intricate
environment.
Voltammetry
is
universal
technique
investigate
complex
matrices
which
could
realize
miniaturization
electrodes,
while
amperometry
serves
well-suited
approach
offering
high
temporal
resolution
favorable
for
fast
oxidation–reduction
kinetics
neurochemicals.
Potentiometry
realizes
quantitative
analysis
by
recording
potential
difference
reduced
invasiveness
compatibility.
FET
OECT
serve
amplification
higher
sensitivity
than
traditional
technologies.
Furthermore,
we
point
out
current
shortcomings
address
challenges
perspectives
Journal of Composites Science,
Journal Year:
2023,
Volume and Issue:
7(11), P. 473 - 473
Published: Nov. 11, 2023
Heavy
metal
ions
(HMIs)
have
acute
toxic
effects
on
health
and
are
dangerous
for
human
existence
the
ecosystem.
Therefore,
their
sensitive
selective
detection
is
of
great
importance.
In
recent
years,
various
nanocomposite
materials
been
used
by
researchers
HMIs
using
modalities
electrochemical
techniques.
This
review
summarizes
advances
in
developing
sensors
based
numerous
detecting
HMIs.
Nanocomposite
materials,
such
as
metal–organic
frameworks
(MOFs),
organic
conducting
polymer
(OCPs),
carbon
nanotubes
(CNTs),
graphene
oxide
(GO),
graphene/reduced
(rGO),
graphitic
nitride,
oxide,
chitosan,
MXenes,
nanoparticle-based
nanocomposites,
etc.,
explored
to
improve
sensing
properties
sensors.
emphasizes
materials’
synthesis
characterization
techniques,
HMI
Moreover,
this
highlights
development
portable
biosensors
real-world
scenarios,
environmental
monitoring,
food
safety,
clinical
diagnosis.
also
demonstrates
importance
a
reliable,
sensitive,
tool
Analytical Chemistry,
Journal Year:
2023,
Volume and Issue:
95(35), P. 13281 - 13288
Published: Aug. 23, 2023
MicroRNAs
(miRNAs)
have
emerged
as
powerful
biomarkers
for
disease
diagnosis
and
screening.
Traditional
miRNA
analytical
techniques
are
inadequate
point-of-care
testing
due
to
their
reliance
on
specialized
expertise
instruments.
Graphene
field-effect
transistors
(GFETs)
offer
the
prospect
of
simple
label-free
diagnostics.
Herein,
a
GFET
biosensor
based
tetrahedral
DNA
nanostructure
(TDN)-assisted
catalytic
hairpin
assembly
(CHA)
reaction
(TCHA)
has
been
fabricated
applied
sensitive
specific
detection
miRNA-21.
TDN
structures
assembled
construct
biosensing
interface,
facilitating
CHA
by
providing
free
space
preventing
unwanted
entanglements,
aggregation,
adsorption
probes
graphene
channel.
Owing
synergistic
effects
TDN-assisted
in
situ
nucleic
acid
amplification
sensing
surface,
well
inherent
signal
sensitization
GFETs,
exhibits
ultrasensitive
miRNA-21
down
5.67
×
10-19
M,
approximately
three
orders
magnitude
lower
than
that
normally
achieved
with
channel
functionalization
single-stranded
probes.
In
addition,
demonstrates
excellent
performance
regarding
selectivity,
stability,
reproducibility.
Furthermore,
practicability
is
verified
analyzing
targets
complex
serum
environment
cell
lysates,
showing
tremendous
potential
bioanalysis
clinical
diagnosis.
Advanced Electronic Materials,
Journal Year:
2024,
Volume and Issue:
10(4)
Published: Jan. 16, 2024
Abstract
Supercapacitors
and
transistors
are
two
key
devices
for
future
electronics
that
must
combine
portability,
high
performance,
easy
scalability,
etc.
Graphene‐related
materials
(GRMs)
frequently
chosen
as
active
these
applications
given
their
unique
physical
properties
tunable
via
chemical
functionalization.
Up
to
date,
among
GRMs,
only
reduced
graphene
oxide
(rGO)
showed
sufficient
versatility
processability
in
mild
media,
rendering
it
suitable
integration
types
of
devices.
Here,
a
sound
alternative
rGO
is
provided,
namely
acetic
acid
(GAA),
whose
physico‐chemical
features
offer
specific
advantages.
In
particular,
the
use
GAA‐based
cathode
zinc
hybrid
supercapacitor
(Zn‐HSC)
delivers
state‐of‐the‐art
gravimetric
capacitance
≈400
F
g
−1
at
current
density
0.05
A
.
Conversely,
LGT,
supported
onto
Si/SiO
2
,
shows
an
ambipolar
behavior
0.1
m
NaCl,
featuring
clear
p‐doping
quantified
by
Dirac
voltage
higher
than
100
mV.
Such
device
successfully
implemented
paper
fluidics,
thereby
demonstrating
feasibility
real‐time
monitoring.
