Behavioural Endpoints of Nile Tilapia (Oreochromis niloticus): Potential Biomarkers for Evaluating the Ecotoxicity of Contaminants of Emerging Concern and Legacy Pollutants DOI
Guilherme Malafaia, Thiarlen Marinho da Luz

Royal Society of Chemistry eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 162 - 202

Published: Oct. 4, 2024

Over the last decade, a range of studies have demonstrated that various fitness-related behaviours are vulnerable to disruption induced by contaminants emerging concern (CECs) and legacy pollutants. However, behavioural responses animals when exposed pollutants/contaminants rarely included in discussions about regulation chemicals. Thus, improve our understanding opportunities challenges for ecotoxicology, this chapter presents synthesis endpoints experimental procedures used evaluate response Nile tilapia (Oreochromis niloticus – non-conventional species ecotoxicology) different CECs By focusing on methodological possibilities be evaluating behaviour Neotropical species, we shed light feasibility reasonableness using animal model as complement or alternative use traditionally toxicology.

Language: Английский

Mechanism insights into the histopathological changes of polypropylene microplastics induced gut and liver in zebrafish DOI Creative Commons
Ran Tian,

Miao Guan,

Lei Chen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 280, P. 116537 - 116537

Published: June 8, 2024

Microplastics (MPs), emerging as significant pollutants, have been consistently detected in aquatic environments, with the Yangtze River experiencing a particularly severe level of microplastic pollution, exceeding all other watersheds China. Polypropylene (PP), plastic most abundantly found middle and lower reaches Basin, has less comprehensive research results into its toxic effects. Consequently, present investigation employed zebrafish model organism to delve toxicological impacts polypropylene microplastics (PP-MPs) diameter 5 μm across varying concentrations (300 mg/L 600 mg/L). Using histopathological, microbiota profiling, transcriptomic approaches, we systematically evaluated impact PP-MPs exposure on intestine liver zebrafish. Histopathological analysis revealed that resulted thinner intestinal walls, damaged mucosa, hepatic cellular damage. Intestinal profiling demonstrated that, richness, uniformity, diversity, homogeneity gut microbes significantly increased after at high concentration. These alterations were accompanied by shifts relative abundance associated pathologies, suggesting profound microbial community structure. Concurrently, transcriptome RT-qPCR indicated downregulation pathways genes cell proliferation regulation DNA damage repair mechanisms contributed damage, ultimately exerting adverse effects liver. Correlation between profiles further highlighted associations downregulated pathways. Collectively, these provide novel insights subacute organisms highlight need for ecological health risks pollution.

Language: Английский

Citations

9
Oral exposure to nanoplastics altered lipid profiles in mouse intestine DOI

Sihuan Luo,

Xiaomei Zhao,

Yijin Wang

et al.

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: 197, P. 115304 - 115304

Published: Feb. 2, 2025

Language: Английский

Citations

1
Analytical challenges in detecting microplastics and nanoplastics in soil-plant systems DOI
Imran Azeem, Noman Shakoor,

Sadaf Chaudhary

et al.

Plant Physiology and Biochemistry, Journal Year: 2023, Volume and Issue: 204, P. 108132 - 108132

Published: Oct. 21, 2023

Language: Английский

Citations

16
Rapid detection of nanoplastic particles by a luminescent Tb-based coordination polymer DOI
Tiankai Sun, Hui Min, Zongsu Han

et al.

Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 35(5), P. 108718 - 108718

Published: June 22, 2023

Language: Английский

Citations

11
Revealing Metabolic Dysregulation Induced by Polypropylene Nano- and Microplastics in Nile Tilapia via Noninvasive Probing Epidermal Mucus DOI
Xiaokang Wu,

Yang Sheng-ao,

Ying Kan

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(23), P. 9416 - 9423

Published: May 29, 2024

A noninvasive sampling technology was conceived, employing a disposable acupuncture needle in conjunction with high-resolution mass spectrometry (termed as direct extractive electrospray ionization spectrometry, NIDS-EESI-MS) to scrutinize the epidermal mucus of Nile tilapia for insights into metabolic dysregulation induced by polypropylene nano- and microplastics. This analytical method initiates dispensing an extraction solvent onto needles coated sample, almost simultaneously applying high voltage generate analyte ions. innovative strategy obliterates necessitation laborious sample preparation, thereby simplifying process. Employing this technique facilitated delineation plethora metabolites, encompassing, but not confined to, amino acids, peptides, carbohydrates, ketones, fatty their derivatives. Follow-up pathway enrichment analysis exposed notable alterations within key pathways, including biosynthesis phenylalanine, tyrosine, tryptophan, lysine degradation, well metabolism valine, leucine, isoleucine pathways tilapia, consequent increased concentrations nanoplastics. These portend potential implications such immune suppression, among other deleterious outcomes. trailblazing application methodology only spares aquatic life from sacrifice also inaugurates ethical paradigm conducting longitudinal studies on same organisms, facilitating detailed investigations long-term effects environmental pollutants. enhances ability observe understand subtle yet significant impacts contaminants over time.

Language: Английский

Citations

4
Dose-dependent inflammatory and neurotoxic effects of polypropylene microplastics in Nile tilapia evidenced by internal extractive electrospray ionization high-resolution mass spectrometry metabolomics DOI
Xiaokang Wu, Susu Pan, Ming Li

et al.

Environmental Chemistry Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

Citations

0
Probing PFOA-induced Metabolic Disorders in Tilapia Through Fish Skin Mucus DOI
Jiaxin Dong, Rui Su, Xiaokang Wu

et al.

Chemical Research in Chinese Universities, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

Citations

0
Chronic exposure to polyethylene terephthalate microplastics induces gut microbiota dysbiosis and disordered hepatic lipid metabolism in mice DOI
Tao Lu, Huan Liu, Xiaoqing Yuan

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 298, P. 118330 - 118330

Published: May 14, 2025

Language: Английский

Citations

0
Metabolic profiles and protein expression responses of Pacific oyster (Crassostrea gigas) to polystyrene microplastic stress DOI
Yu Liu, Shuai Wu, Lipin Chen

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 462, P. 140961 - 140961

Published: Aug. 23, 2024

Language: Английский

Citations

2
Machine learning encodes urine and serum metabolic patterns for autoimmune disease discrimination, classification and metabolic dysregulation analysis DOI
Qiuyao Du, Xiao Wang, Junyu Chen

et al.

The Analyst, Journal Year: 2023, Volume and Issue: 148(18), P. 4318 - 4330

Published: Jan. 1, 2023

Machine learning of urine and serum metabolic patterns encodes the discrimination classification autoimmune diseases. The selected metabolite panel, dysregulation disturbance pathways were investigated.

Language: Английский

Citations

4