Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(27)
Published: April 24, 2024
Single-atom
nanozymes
(SAzymes)
with
atomically
dispersed
active
sites
are
potential
substitutes
for
natural
enzymes.
A
systematic
study
of
its
multiple
functions
can
in-depth
understand
SAzymes's
nature,
which
remains
elusive.
Here,
we
develop
a
novel
ultrafast
synthesis
sputtered
SAzymes
by
in
situ
bombarding-embedding
technique.
Using
this
method,
copper
(Cu)
(CuSA)
is
developed
unreported
unique
planar
Cu-C
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(20), P. 12639 - 12671
Published: May 8, 2024
Since
the
discovery
of
ferromagnetic
nanoparticles
Fe3O4
that
exhibit
enzyme-like
activity
in
2007,
research
on
nanoenzymes
has
made
significant
progress.
With
in-depth
study
various
and
rapid
development
related
nanotechnology,
have
emerged
as
a
promising
alternative
to
natural
enzymes.
Within
nanozymes,
there
is
category
metal-based
single-atom
nanozymes
been
rapidly
developed
due
low
cast,
convenient
preparation,
long
storage,
less
immunogenicity,
especially
higher
efficiency.
More
importantly,
possess
capacity
scavenge
reactive
oxygen
species
through
mechanisms,
which
beneficial
tissue
repair
process.
Herein,
this
paper
systemically
highlights
types
metal
their
catalytic
recent
applications
repair.
The
existing
challenges
are
identified
prospects
future
composed
metallic
nanomaterials
proposed.
We
hope
review
will
illuminate
potential
repair,
encouraging
sequential
clinical
translation.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(27)
Published: April 24, 2024
Abstract
Single‐atom
nanozymes
(SAzymes)
with
atomically
dispersed
active
sites
are
potential
substitutes
for
natural
enzymes.
A
systematic
study
of
its
multiple
functions
can
in‐depth
understand
SAzymes's
nature,
which
remains
elusive.
Here,
we
develop
a
novel
ultrafast
synthesis
sputtered
SAzymes
by
in
situ
bombarding‐embedding
technique.
Using
this
method,
copper
(Cu)
(CuSA)
is
developed
unreported
unique
planar
Cu‐C
3
coordinated
configuration.
To
enhance
the
tumor‐specific
targeting,
employ
bioorthogonal
approach
to
engineer
CuSA,
denoted
as
CuSACO.
CuSACO
not
only
exhibits
minimal
off‐target
toxicity
but
also
possesses
exceptional
ultrahigh
catalase‐,
oxidase‐,
peroxidase‐like
multienzyme
activities,
resulting
reactive
oxygen
species
(ROS)
storm
generation
effective
tumor
destruction.
Surprisingly,
release
Cu
ions
presence
glutathione
(GSH)
induce
cuproptosis,
enhancing
treatment
efficacy.
Notably,
CuSACO′s
remarkable
photothermal
properties
enables
precise
therapy
(PTT)
on
tumors.
This,
combined
nanozyme
catalytic
cuproptosis
and
immunotherapy,
efficiently
inhibiting
growth
orthotopic
breast
tumors
gliomas,
lung
metastasis.
Our
research
highlights
an
innovative
strategy
utilize
mechanism
therapeutic
efficacy,
broadening
exploration
development
enzyme‐like
behavior
physiological
action
SAzymes.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
Nanozymes
with
intrinsic
enzyme-like
properties
have
garnered
significant
attention
in
cancer
treatment.
However,
effective
methods
to
evaluate
situ
the
catalytic
activity
of
nanozymes
living
systems
remain
lacking.
Herein,
we
pioneeringly
present
a
novel
probe
(1-FCuSA)
for
self-reporting
nanozyme
activity,
which
integrates
diene
electrochromic
material
(EM
1)
and
copper
single-atom
(FCuSA)
peroxidase
(POD)-like
activity.
This
system
is
designed
self-predict
its
through
ratiometric
photoacoustic
(PA)
imaging
signal.
Initially,
1-FCuSA
exhibits
low
PA
ratio
(PA808/PA1064)
between
808
1064
nm.
Upon
reaction
hydroxyl
radicals
(•OH)
generated
by
POD-like
FCuSA,
signal
at
nm
significantly
increases,
while
remains
stable.
results
an
obvious
increase
PA808/PA1064,
enabling
accurate
monitoring
•OH
production
during
nanozyme-catalyzed
therapy.
Thus,
not
only
induces
specific
vivo
tumor
treatment
but
also
provides
real-time
efficiency
imaging.
innovative
approach
may
offer
new
insights
into
early
prediction
anticancer
efficacy
guide
application
systems.
