Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 270, P. 116954 - 116954
Published: Nov. 17, 2024
Language: Английский
Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(10), P. 4224 - 4231
Published: Feb. 29, 2024
The detection of physiological phosphates (PPs) is great importance due to their essential roles in numerous biological processes, but the efficient different PPs simultaneously remains challenging. In this work, we propose a fluorescence sensor array for detecting based on metal-ion-regulated gold nanoclusters (AuNCs) via an indicator-displacement assay. Zn2+ and Eu3+ are selected assemble with two AuNCs, resulting quenching or enhancing fluorescence. Based competitive interaction metal ions AuNCs PPs, will be recovered owing disassembly AuNC-metal ion ensembles. Depending PPs' distinct responses, four-channel was established. not only exhibits good discrimination capability eight kinds (i.e., ATP, ADP, AMP, GTP, CTP, UTP, PPi, Pi) linear discriminant analysis also enables quantitative single phosphate (e.g., ATP) presence interfering mixtures. Moreover, potential application present real samples cell lysates serum) successfully demonstrated performance. This work illustrates ion-regulated as new sensing platform differential well other disease-related biomolecules.
Language: Английский
Citations
20
ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(3), P. 801 - 821
Published: Feb. 2, 2024
As a new type of transdermal drug delivery system (TDDS), microneedles have garnered significant attention for their noninvasiveness, portability, controllable administration, and wide-ranging loading capacity. While initially designed administration via the stratum corneum minimizing adverse reactions associated with systemic enhancing patient compliance, recently found applications in multitude medical contexts. Hence, potential transcends mere delivery. Recent reviews on extensively covered various aspects, including needle types, materials, manufacturing methods, as well treating skin diseases. This review aims to provide comprehensive overview diverse designs from different perspectives, which encompass traditional integrated more intelligent structurally optimized ones nowadays. Additionally, this offers analysis material properties utilized applications, nondegradable materials degradable materials. Furthermore, presents these scenarios such regeneration repair, disease treatment, monitoring, prevention. Moreover, discussion article highlights future clinical necessary efforts required achieve widespread adoption. serves valuable reference bridging gap between laboratory setting practice terms using scenarios.
Language: Английский
Citations
19
Aggregate, Journal Year: 2024, Volume and Issue: 5(3)
Published: Jan. 25, 2024
Abstract The management of infected wounds is always great significance and urgency in clinical biomedical fields. Recent efforts this area are focusing on the development functional wound patches with effective antibacterial, drug delivery, sensor properties. Here, we present novel hyaluronic acid (HA) microneedle these features by encapsulating aminobenzeneboronic acid‐modified gold nanoclusters (A‐GNCs) for management. A‐GNCs loaded were derived from negative‐mold replication showed high mechanical strength to penetrate skin. release was realized degradation HA, self‐monitor released actives based dynamic bright orange fluorescence emitted under ultraviolet radiation. As could destroy bacteria membranes, excellent vitro antibiosis ability. Based features, have demonstrated inhibition, residual self‐monitoring, healing promotion abilities Escherichia coli‐ or Staphylococcus aureus ‐infected These results indicated potential such applications.
Language: Английский
Citations
18
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: Feb. 18, 2025
Language: Английский
Citations
13
Progress in Materials Science, Journal Year: 2023, Volume and Issue: 142, P. 101229 - 101229
Published: Dec. 12, 2023
Gold nanomaterials have emerged as versatile systems which hold a great promise for several biomedical applications. Among them, gold nanoclusters (AuNCs), ultra-small nanoparticles, gained attention due to their unique optical and electronic properties arising from small size, quantum confinement effects, surface ligands. Their biocompatibility, efficient renal clearance, photoluminescence (PL), catalytic activity make them candidates practical applications, such bioimaging therapy. In this review, we devote our the burgeoning research in area focusing on three main highly intertwined topics. First, present different methods AuNC synthesis alongside key of AuNCs (magnetism, PL). This is followed by description how fine-tune PL property. Lastly, potential applications are discussed detail, with particular focus sensing, bioimaging, nanomedicine.
Language: Английский
Citations
27
Talanta, Journal Year: 2024, Volume and Issue: 274, P. 126025 - 126025
Published: March 31, 2024
Language: Английский
Citations
13
Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(27), P. 5871 - 5891
Published: March 4, 2024
Language: Английский
Citations
10
ACS Sensors, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Microneedle (MN) sensors have great promise for food safety detection, but the rapid preparation of MNs surface-enhanced Raman scattering (SERS) with tunable and homogeneous nanoparticles remains a challenge. To address this, SERS sensor gold nanoparticles@polydopamine@poly(methyl methacrylate) MN (AuNPs@PDA@PMMA-MN) was developed. The extended-Derjaguin−Landau−Verwey−Overbeek theory applied to calculate interaction energy between AuNPs PDA. It confirmed that an appropriate centrifugal force could be utilized overcome electrostatic repulsion Together adhesion PDA, can therefore uniformly densely deposited on substrate. AuNPs@PDA@PMMA-MN had enhancement factor up 1.74 × 106 R6G. Furthermore, selective detection putrescine cadaverine successfully constructed by modifying 4-mercaptobenzaldehyde (4-MBA) substrates. This quantitatively detect in meat. has been situ real meat samples. advantages facile fabrication, high sensitivity, specificity, online, capability. is expected applications quality testing, environmental monitoring, disease diagnosis.
Language: Английский
Citations
1
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
Aggregation-induced emission (AIE) or aggregation-induced enhancement (AIEE) has endowed gold species with responsive fluorescent properties, favoring their potential applications in sensing, imaging, and therapy. However, it remains an interesting challenge to fabricate fluorophores both AIE AIEE effects. Herein, we presented highly luminescent Au(I) thiolate nanocomplex-based biosensors Zn2+ induced-AIE zeolite imidazolate framework (ZIF-8) induced-AIEE The nonemissive monovalent gold–glutathione complexes (AuI-SGs) were obtained synthesize the core–shell Zn2+/AuI-SG@ZIF-8 composites strong luminescence via coordination-assisted self-assembly strategy. By immobilizing GOx on surface of Zn2+/AuI-SG@ZIF-8, Zn2+/AuI-SG@ZIF-8/GOx exhibited effective responsiveness glucose, showing a "turn-off" detection model. mechanism study revealed that robust glucose sensing was attributed acid-stimulated degradation probe facilitated by H+ generated from oxidase (GOx)-catalyzed oxidation process. To achieve noninvasive intelligent blood detection, Zn2+/AuI-SG@ZIF-8/GOx-loaded microneedle (MN)-patch platform further developed. MN-patch-based had promising performance for on-needle capture situ detection. This demonstrated universal feasible protocol construct development MN-based analytical devices.
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161331 - 161331
Published: March 1, 2025
Language: Английский
Citations
1