One-Pot Fabrication of Kinetically Inert Ultrasmall Manganese(II) Chelate-Backboned Polymer Contrast Agents for High-Performance Magnetic Resonance Imaging DOI
Shengxiang Fu, Muhammad Rizwan Younis,

Zhongyuan Cai

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(45), P. 14252 - 14262

Published: Oct. 14, 2024

Traditional macromolecules or nanoscale Mn2+ chelate-based magnetic resonance imaging (MRI) contrast agents (CAs) suffer from complicated and laborious synthesis processes, relatively low kinetic stability T1 relaxivity, limiting their clinical applications. Herein, we fabricated a series of kinetically inert chelate-backboned polymers, P(MnL-PEG), through facile one-pot polymerization process. Particularly, P(MnL-PEG)-3 demonstrates significantly higher relaxivity 23.9 Mn mM–1 s–1 at 1.5 T than that previously reported small molecules CAs. Due to its high extended blood circulation, hepatocyte-specific uptake, kidneys metabolism, presents enhanced in vessel, liver, compared Gd3+-based CAs (Gd-EOB-DTPA Gd-DOTA) dosage 0.05 mmol Mn/Gd kg–1 BW, can accurately diagnose orthotopic H22 liver tumors vivo animal models. We anticipate this work will promote the development clinically relevant MRI

Language: Английский

Advancements in manganese complex-based MRI agents: Innovations, design strategies, and future directions DOI
Shubham Roy,

Jingsi Gu,

Wujiong Xia

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(9), P. 104101 - 104101

Published: July 16, 2024

Language: Английский

Citations

4
Large-Scale Synthesis of Non-Ionic Bismuth Chelate for Computed Tomography Imaging in Vivo DOI
Yuping Zhang, Jun Deng, Maik Lang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123122 - 123122

Published: Jan. 24, 2025

Language: Английский

Citations

0
Innovations in Quantitative Rapid Testing: Early Prediction of Health Risks DOI

Khaled S Alleilem,

Saad Almousa,

Mohammed Alissa

et al.

Current Problems in Cardiology, Journal Year: 2025, Volume and Issue: unknown, P. 103000 - 103000

Published: Feb. 1, 2025

Language: Английский

Citations

0
Hybrid Sensor Integration in Wearable Devices for Improved Cardiovascular Health Monitoring DOI Creative Commons
Bangul Khan,

Waqar Ahmad Khan,

M. Abul Masrur

et al.

Journal of Science Advanced Materials and Devices, Journal Year: 2025, Volume and Issue: unknown, P. 100889 - 100889

Published: April 1, 2025

Language: Английский

Citations

0
Imaging technology in tracking the intravital fate of transplanted stem cells DOI Creative Commons
Liming Shen, Chengze Li, Yulian Li

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107752 - 107752

Published: April 1, 2025

Language: Английский

Citations

0
Lipophilic Group-Modified Manganese(II)-Based Contrast Agents for Vascular and Hepatobiliary Magnetic Resonance Imaging DOI

Zhongyuan Cai,

Lingling Jiang,

Yingzi Cao

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(6), P. 5011 - 5031

Published: March 7, 2024

Effective vascular and hepatic enhancement better safety are the key drivers for exploring gadolinium-free hepatobiliary contrast agents. Herein, a facile strategy proposes that high lipophilicity may be favorable to enhancing sequentially signal intensity based on structure–activity relationship both uptake interaction with serum albumins partly depend lipophilicity. Therefore, 11 newly synthesized derivatives of manganese o-phenylenediamine-N,N,N′,N′-tetraacetic acid (MnLs) were evaluated as The maximum intensities heart, liver, kidneys strongly correlated log P, indicator most lipophilic agent, MnL6, showed relaxivity when binding albumin, good enhancement, rapid excretion, reliable phases comparable classic gadolinium ethoxybenzyl diethylenetriamine pentaacetic (Gd-EOB-DTPA) in vivo liver tumor imaging. Inhibition experiments confirmed targeting MnL6 is mediated by organic anion-transporting polypeptides.

Language: Английский

Citations

2
Fluorinated 1,7-DO2A-Based Iron(II) Complexes as Sensitive 19F MRI Molecular Probes for Visualizing Renal Dysfunction in Living Mice DOI
Lingxuan Li,

Chaoxian Chen,

Yifan Bu

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(26), P. 10827 - 10834

Published: June 17, 2024

Kidney diseases have become an important global health concern due to their high incidence, inefficient diagnosis, and poor prognosis. Devising direct methods, especially imaging means, assess renal function is the key for better understanding mechanisms of various kidney subsequent development effective treatment. Herein, we developed a fluorinated ferrous chelate-based sensitive probe, 1,7-DO2A-Fe(II)-F18 (Probe 1), 19F magnetic resonance (MRI). This highly probe (containing 18 chemically equivalent atoms with fluorine content at 35 wt %) achieves 15-time enhancement in signal intensity compared fluorine-containing ligand alone appropriately regulated relaxation times by ion, which significantly increases sensitivity reduces acquisition time. Owing its aqueous solubility, biostability, biocompatibility, this could be rapidly cleared kidneys, provides means monitoring dysfunction via MRI. With accomplish vivo impaired caused including acute injury, unilateral ureteral obstruction, fibrosis different stages. Our study illustrates promising potential Probe 1 real-time visualization dysfunction, beneficial study, even stratification diseases. Furthermore, design strategy our inspiring more high-performance MRI probes biological processes.

Language: Английский

Citations

2
New approaches to acute kidney injury DOI Creative Commons
Sanjeev Noel,

R. Kapoor,

Hamid Rabb

et al.

Clinical Kidney Journal, Journal Year: 2024, Volume and Issue: 17(Supplement_2), P. 65 - 81

Published: Nov. 22, 2024

ABSTRACT Acute kidney injury (AKI) is a common and serious clinical syndrome that involves complex interplay between different cellular, molecular, metabolic immunologic mechanisms. Elucidating these pathophysiologic mechanisms crucial to identify novel biomarkers therapies. Recent innovative methodologies the advancement of existing technologies has accelerated our understanding AKI led unexpected new therapeutic candidates. The aim this review introduce update reader about recent developments applying in omics, imaging, nanomedicine artificial intelligence research, plus provide examples where can be translated improve patient care.

Language: Английский

Citations

1
One-Pot Fabrication of Kinetically Inert Ultrasmall Manganese(II) Chelate-Backboned Polymer Contrast Agents for High-Performance Magnetic Resonance Imaging DOI
Shengxiang Fu, Muhammad Rizwan Younis,

Zhongyuan Cai

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(45), P. 14252 - 14262

Published: Oct. 14, 2024

Traditional macromolecules or nanoscale Mn2+ chelate-based magnetic resonance imaging (MRI) contrast agents (CAs) suffer from complicated and laborious synthesis processes, relatively low kinetic stability T1 relaxivity, limiting their clinical applications. Herein, we fabricated a series of kinetically inert chelate-backboned polymers, P(MnL-PEG), through facile one-pot polymerization process. Particularly, P(MnL-PEG)-3 demonstrates significantly higher relaxivity 23.9 Mn mM–1 s–1 at 1.5 T than that previously reported small molecules CAs. Due to its high extended blood circulation, hepatocyte-specific uptake, kidneys metabolism, presents enhanced in vessel, liver, compared Gd3+-based CAs (Gd-EOB-DTPA Gd-DOTA) dosage 0.05 mmol Mn/Gd kg–1 BW, can accurately diagnose orthotopic H22 liver tumors vivo animal models. We anticipate this work will promote the development clinically relevant MRI

Language: Английский

Citations

0