Facile Synthesis of Rigid Binuclear Manganese Complexes for Magnetic Resonance Angiography and SLC39A14-Mediated Hepatic Imaging

Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: 35(5), P. 703 - 714

Published: May 6, 2024

Manganese(II)-based contrast agents (MBCAs) are potential candidates for gadolinium-free enhanced magnetic resonance imaging (MRI). In this work, a rigid binuclear MBCA (Mn2-PhDTA2) with zero-length linker was developed via facile synthetic routes, while the other dimer (Mn2-TPA-PhDTA2) longer also synthesized more complex steps. Although molecular weight of Mn2-PhDTA2 is lower than that Mn2-TPA-PhDTA2, their T1 relaxivities similar, being increased by over 71% compared to mononuclear Mn-PhDTA. presence serum albumin, relaxivity slightly possibly due affinity constant. The transmetalation reaction copper(II) ions confirmed has an ideal kinetic inertness dissociation half-life approximately 10.4 h under physiological conditions. variable-temperature 17O NMR study, both Mn-PhDTA and demonstrated similar estimated q close 1, indicating formation monohydrated complexes each manganese(II) ion. addition, superior enhancement in vivo vascular hepatic MRI can be rapidly cleared through dual renal excretion pattern. uptake mechanism mediated SLC39A14 validated cellular studies.

Language: Английский

A novel albumin-binding macrocyclic Gd-HPDO3A complex bearing a deoxycholic acid residue: the role of the hydration state, water exchange and local dynamics in the observed relaxivity

Inorganic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(19), P. 6511 - 6526

Published: Jan. 1, 2024

Improved efficiency of an HSA-binding Gd-complex: the role hydration state, water exchange and local dynamics in observed relaxivity a highly stable macrocyclic Gd-HPDO3A complex bearing deoxycholic acid residue.

Language: Английский