Progress in electrochemiluminescence of metal nanoclusters DOI Open Access
Xiaojian Wang, Kaiyang Kuang, Mengmeng Jing

et al.

Chemical Physics Reviews, Journal Year: 2024, Volume and Issue: 5(4)

Published: Dec. 1, 2024

Metal nanoclusters (NCs) composed of metal atoms and ligands show promise as electrochemiluminescent (ECL) materials due to their optical electrochemical properties. This review provides a comprehensive overview the ECL mechanisms, advantages, roles NCs luminophores, catalysts, quenchers, substrates, carriers. Insights into factors that influence in will lay foundation for future research. In addition, applications metallic NC-based detection platforms are summarized, potential research directions presented.

Language: Английский

Recent advances in low‐background luminescent nanomaterials‐enhanced lateral flow assays for clinical diagnosis DOI Creative Commons

Liangwen Hao,

Jing Chen,

Quanshuang Li

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Lateral flow assays (LFAs) are widely applicable in clinical point‐of‐care testing (POCT) due to their unique advantages such as simplicity, rapidity, and cost‐effectiveness. However, sensitivity is often constrained by the background autofluorescence of biological sample, self‐matrix, or readout technique, thereby leading overlooking trace amounts biomarkers present early disease. In recent years, various nanomaterials‐based methods have been developed address this issue, including time‐gated wavelength‐differentiated strategy external modulated for separation minimize interference from samples. This review provides a comprehensive overview low‐background luminescent nanoparticles (LBLNPs)‐enhanced LFA systems, focusing on analyzing underlying mechanism these nanomaterials improving accuracy LFAs platform diagnosis. Representative examples selected demonstrate potential detecting disease‐associated samples blood, urine, saliva et al. Finally, unresolved challenges future development prospects briefly discussed.

Language: Английский

Citations

1
High-efficiency electrochemiluminescence of host-guest ligand-assembled gold nanoclusters preoxidated for ultrasensitive biosensing of protein DOI
Shuang Hu, Hongwen Zhao,

Pan Xie

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 419, P. 136347 - 136347

Published: Aug. 1, 2024

Language: Английский

Citations

4
Spatial Confinement-Enhanced Electrochemiluminescence of Gold Nanoclusters on 3D Porous ZrO2 Hollow Nanospheres for the Assessment of Acute Myocardial Infarction Protein Markers DOI

Zhu Xiaochun,

Xiaofeng Wang,

Huimei Su

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Herein, the gold nanoclusters@three-dimensional (3D) porous ZrO2 hollow nanospheres (Au NCs@ZrO2) with spatial confinement-enhanced electrochemiluminescence (SCE-ECL) were first prepared to fabricate a biosensing platform for ultrasensitive detection of insulin-like growth factor 1 (IGF-1), which was associated cardiovascular disease, malignant tumor, and neuropathic pain. Specifically, confinement Au NCs in 3D microenvironment significantly boosted optical radiation excited because vibration ligand molecules restricted, recombination holes electrons facilitated process enhancing ECL efficiency, resulting 5.1-fold stronger efficiency than NCs. As proof concept, based on NCs@ZrO2 as an emitter orderly localized catalytic hairpin self-assembly (OL-CHA) system signal amplifier, built achieved fast trace determination IGF-1 limit (LOD) down 0.36 fg/mL. Moreover, realized assessment expression acute myocardial infarction (AMI) patients exhibited more prominent accuracy enzyme-linked immunosorbent assay (ELISA). This work proposed neoteric avenue developing highly efficient emitters, presented promising prospect bioanalysis early diagnosis diseases.

Language: Английский

Citations

0
Surface-Defect-Involved Chemiluminescence Boosted by Gold–Silver Bimetallic Nanoclusters for Bioanalysis DOI

Tongtong Zhai,

Luyao Zhang,

Sipeng Tian

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Chemiluminescence (CL) as a powerful analytical tool has garnered increasing interest. However, traditional molecular-based CL luminophores suffer from low emission efficiency due to limited total photons emitted per luminophore, driving efforts explore amplified strategies or novel probes boost the emission. Although metal nanoclusters (NCs) luminescent nanoprobes have been extensively studied for electrochemiluminescence and photoluminescence (PL) owing their intriguing properties, performance using NCs emitters is often ignored. Herein, based on synergistic effect within bimetallic NCs, series of glutathione-coated Au-Ag (GSH-AuAg NCs) were optimized by adjusting precursor ratios achieved maximum response at Au:Ag molar ratio 5:1. To our surprise, with GSH-AuAg was triggered oxidant reagents such KMnO4, display boosted (ca. 6.2-fold) compared monometallic enhancing efficiency. Surface-defect-involved revealed collecting spectra wavelength around 750 nm an obvious red shift 140 PL spectra. The mechanism reveals KMnO4-injected hole into valence band through redox reactions GSH ligands, leading efficient radiative charge recombination pre-existing electron. A sensing platform NCs/oxidant system constructed H2O2 glucose, demonstrating potential in applications.

Language: Английский

Citations

0
Dual-emission copper nanoclusters for hydrogen sulfide detection: a novel approach DOI

Longyan Wang,

Huachao Che,

Lizhu Fang

et al.

Analytical Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Dual-emission copper nanoclusters (CuNCs) were synthesized via a novel, green and one-pot aqueous method, employing bovine serum albumin glutathione as reducing stabilizing agents, respectively.

Language: Английский

Citations

0
Advanced Electrochemiluminescence Biosensing Enabled by High-Performance Lipophilic [AuAg24(SPhMe2)18]– Nanoclusters Coupled with Bipolar Electrochemistry DOI

Hongfei Ji,

Mingyue Chen, Yuzhu Sun

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137840 - 137840

Published: April 1, 2025

Language: Английский

Citations

0
Advanced Electrochemiluminescent approaches for contaminant detection in food matrices using metal-organic framework composites DOI
Brij Mohan, Stefan Ručman, Pisith Singjai

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 470, P. 142625 - 142625

Published: Dec. 24, 2024

Language: Английский

Citations

3
Electron-Accelerator-Induced Fast Electron Transfer for Enhancing Electrochemiluminescence of Gold Nanoclusters and Its Bioanalysis Application: A Novel Avenue for Developing High-Efficient Emitters DOI
Xiaochun Zhu,

Huimei Su,

Yuxi Song

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(33), P. 13616 - 13624

Published: Aug. 8, 2024

Herein, the gold nanoclusters/CaFe2O4 nanospheres (Au NCs/CaFe2O4) heterostructure as a novel electrochemiluminescence (ECL) emitter was developed. Excitingly, Au NCs/CaFe2O4 displayed highly efficient and greatly stable ECL based on newly defined electron-accelerator p-type semiconductor CaFe2O4 NS-induced fast electron transfer; it solved one key obstacle of metal NC-based emitters: sluggish through-covalent bond transport kinetics-caused inferior performance. Specifically, account energy level matching between NCs NSs, valence band (VB) could provide abundant holes for rapidly transporting electrogenerated from highest occupied molecular orbital (HOMO) to electrode, generating massive excited species strong emission. Notably, emerged 5.4-fold higher efficiency with 3.5-fold electrochemical oxidation current in comparison pure NCs, exhibiting great prospects extensive lighting installations, ultrasensitive biosensing, high-resolution imagery. As applications, an bioassay platform constructed U-like structure-fueled catalytic hairpin assembly (U-CHA) signal amplifier trace analysis aflatoxin B1 (AFB1) detection limit (LOD) down 2.45 fg/mL, which 3 orders magnitude than that previous biosensors much better stability. This study developed entirely new avenue enlarging performance is very attractive orientation directing reasonable design prominent emitters broadening practical application NCs.

Language: Английский

Citations

1
Bivariate tracking of NIR phototherapeutic probe that illuminates the deterioration process of NAFLD-HCC DOI
Jialu Yang, Huimin Xu,

Yijun Zhao

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: unknown, P. 116967 - 116967

Published: Nov. 1, 2024

Language: Английский

Citations

1
Progress in electrochemiluminescence of metal nanoclusters DOI Open Access
Xiaojian Wang, Kaiyang Kuang, Mengmeng Jing

et al.

Chemical Physics Reviews, Journal Year: 2024, Volume and Issue: 5(4)

Published: Dec. 1, 2024

Metal nanoclusters (NCs) composed of metal atoms and ligands show promise as electrochemiluminescent (ECL) materials due to their optical electrochemical properties. This review provides a comprehensive overview the ECL mechanisms, advantages, roles NCs luminophores, catalysts, quenchers, substrates, carriers. Insights into factors that influence in will lay foundation for future research. In addition, applications metallic NC-based detection platforms are summarized, potential research directions presented.

Language: Английский

Citations

1