Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 24, 2024
The
coordination
number
of
metal
single-atoms,
being
an
important
factor,
should
be
precisely
controlled
as
it
affects
both
activity
and
specificity.
Herein,
the
introduction
nitrogen
into
para
position
benzene
in
graphyne
(2N-GY)
is
proposed
a
carrier
for
anchoring
single-atoms
onto
pyrazine
nitrogen.
These
atoms
are
then
coordinated
to
center
rhombic
cavity,
ensuring
numbers.
Inspired
by
natural
enzymes,
series
transition
single-atom
nanozymes
(SANs)
constructed
utilizing
2N-GY.
Both
theory
calculations
experiments
demonstrated
that
incorporation
Fe,
Mn,
Mo
effectively
augmented
enzyme-like
activity,
with
Mo/GY
exhibiting
highest
peroxidase
-like
activity.
Based
on
differing
activities
M/GY
(M
=
Mo)
varying
abilities
sulfhydryl
groups
biothiols
occupy
active
sites,
sensing
arrays
high-throughput
identification
six
constructed.
After
combining
fingerprint
feature
responses
SANs
machine
learning
algorithms,
efficient
distinction
achieved.
This
study
introduces
novel
pathway
designing
synthesizing
mimic
enzymes.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(21), P. 8221 - 8233
Published: May 13, 2024
Compared
with
traditional
"lock–key
mode"
biosensors,
a
sensor
array
consists
of
series
sensing
elements
based
on
intermolecular
interactions
(typically
hydrogen
bonds,
van
der
Waals
forces,
and
electrostatic
interactions).
At
the
same
time,
arrays
also
have
advantages
fast
response,
high
sensitivity,
low
energy
consumption,
cost,
rich
output
signals,
imageability,
which
attracted
widespread
attention
from
researchers.
Nanozymes
are
nanomaterials
own
enzyme-like
properties.
Because
adjustable
activity,
stability,
cost
effectiveness
nanozymes,
they
potential
candidates
for
construction
to
different
signals
analytes
through
chemoresponse
colorants,
solves
shortcomings
sensors
that
cannot
support
multiple
detection
lack
universality.
Recently,
nanozymes
as
nonspecific
recognition
receptors
has
much
more
researchers
been
applied
precise
proteins,
bacteria,
heavy
metals.
In
this
perspective,
is
given
regulation
their
activity.
Particularly,
building
principles
methods
analyzed,
applications
summarized.
Finally,
approaches
overcome
challenges
perspectives
presented
analyzed
facilitating
further
research
development
nanozyme
arrays.
This
perspective
should
be
helpful
gaining
insight
into
ideas
within
field
