Multi‐Mode/Signal Biosensors: Electrochemical Integrated Sensing Techniques

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

Abstract Electrochemical (EC) analysis has emerged as a high‐sensitivity, reliable, cost‐effective, and rapidly evolving technique that garnered significant attention across diverse domains. Furthermore, EC‐based techniques hold great potential for miniaturization integration. The integration of EC with mode/signal (such light, magnetic, thermal signals, etc.) provides unique opportunities biosensors to acquire more information through single sensing platform. By coupling multiple signals or processing them logically, the detection accuracy can be further improved, probability false positives negatives minimized. In this review, thorough multi‐ sensors in field is conducted, along their various (e.g., fluorescence, photothermal, colorimetry, microfluidic, etc.). aim delve into latest advances, applications, well challenges multi‐mode/signal biosensors, where utilization modalities helps enhance accuracy, sensitivity, selectivity. This review new insight synergistic effects integrating other techniques, aiming shed light on near‐future developments EC‐integrated biosensors.

Language: Английский

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Recent advances in MOF-based nanozymes: Synthesis, activities, and bioapplications

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 263, P. 116593 - 116593

Published: July 18, 2024

Language: Английский

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Nanozyme‐Enabled Biomedical Diagnosis: Advances, Trends, and Challenges

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 13, 2024

Abstract As nanoscale materials with the function of catalyzing substrates through enzymatic kinetics, nanozymes are regarded as potential alternatives to natural enzymes. Compared protein‐based enzymes, exhibit attractive characteristics low preparation cost, robust activity, flexible performance adjustment, and versatile functionalization. These advantages endow them wide use from biochemical sensing environmental remediation medical theranostics. Especially in biomedical diagnosis, feature catalytic signal amplification provided by makes emerging labels for detection biomarkers diseases, rapid developments observed recent years. To provide a comprehensive overview progress made this dynamic field, here an diagnosis enabled is provided. This review first summarizes synthesis nanozyme then discusses main strategies applied enhance their activity specificity. Subsequently, representative utilization combined biological elements disease reviewed, including related metabolic, cardiovascular, nervous, digestive diseases well cancers. Finally, some development trends nanozyme‐enabled highlighted, corresponding challenges also pointed out, aiming inspire future efforts further advance promising field.

Language: Английский

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Advances in multiplexed photoelectrochemical sensors for multiple components

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159319 - 159319

Published: Jan. 1, 2025

Language: Английский

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Multiplex Signal Transduction and Output at Single Recognition Interface of Multiplexed Photoelectrochemical Sensors

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(20), P. 8147 - 8159

Published: April 3, 2024

ADVERTISEMENT RETURN TO ARTICLES ASAPPREVReviewNEXTMultiplex Signal Transduction and Output at Single Recognition Interface of Multiplexed Photoelectrochemical SensorsXin Li*Xin LiHubei Key Laboratory Pollutant Analysis & Reuse Technology, College Chemistry Chemical Engineering, Hubei Normal University, Huangshi 435002, P. R. China*Email: [email protected]More by Xin LiView Biographyhttps://orcid.org/0000-0002-9222-5877, Guixiang ChenGuixiang ChenHubei ChinaMore ChenView Biography, Yishuang LiYishuang Yuxin WangYuxin WangHubei WangView Wan HuangWan HuangHubei HuangView Guosong Lai*Guosong LaiHubei LaiView Biographyhttps://orcid.org/0000-0002-8083-1378Cite this: Anal. Chem. 2024, XXXX, XXX, XXX-XXXPublication Date (Web):April 3, 2024Publication History Received1 December 2023Accepted27 March 2024Revised18 February 2024Published online3 April 2024https://doi.org/10.1021/acs.analchem.3c05475© 2024 American SocietyRequest reuse permissionsArticle Views-Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Electrodes,Interfaces,Materials,Quantum mechanics,Sensors Get e-Alerts

Language: Английский

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High-entropy (ZnCdCuAgCo)xS-triggered cocktail effect with cation-exchange reaction for in-situ amplified photoelectrochemical immunoassay

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 412, P. 135798 - 135798

Published: April 9, 2024

Language: Английский

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Enhanced Label-Free Photoelectrochemical Strategy for Pollutant Detection: Using Surface Oxygen Vacancies-Enriched BiVO₄ Photoanode

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(24), P. 9944 - 9952

Published: June 6, 2024

Label-free photoelectrochemical sensors have the advantages of high sensitivity and a simple electrode structure. However, its performance is greatly limited due to photoactive materials' weak photoactivity poor stability. Herein, robust homogeneous (PEC) aptasensor has been constructed for atrazine (ATZ) based on photoetching (PE) surface oxygen vacancies (Ov)-enriched Bismuth vanadate (BiVO4) (PE-BVO). The Ov improves carrier separation ability BiVO4, thus providing superior signal substrate sensor. A thiol molecular layer self-assembled PE-BVO acts as blocker, while 2D graphene signal-on probe after release from aptamer–graphene complex. fabricated sensor wide linear detection range 0.5 pM 10.0 nM low limit 0.34 (S/N = 3) ATZ. In addition, it can efficiently work in pH (3–13) ionic strength (∼6 M Na+), which provides promising opportunities detecting environmental pollutants under complex conditions.

Language: Английский

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Ultrasensitive Electrochemiluminescence Biosensor with ZIF‐67@MXene as an Efficient Co‐Reaction Accelerator and Plasmonic Nanozyme as a Smart Signal Amplification Probe

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Abstract Exploring novel electrochemiluminescence (ECL) co‐reaction accelerators to construct ultrasensitive sensing systems is a prominent focus for developing advanced ECL sensors. However, challenges still remain in finding highly efficient and understanding their promoting mechanisms. In this paper, ZIF‐67@MXene nanosheet composites, with conductive in‐plane structure confined‐stable pore/channel, are designed act as high‐efficient achieve significant enhancement the luminol‐H 2 O based system. Mechanism investigation suggests that hydroxyl radicals (·OH) singlet oxygen ( 1 ) can be selectively preferentially generated on due stable absorption of ·OH , leading remarkable efficiency luminol (830%). Finally, by designing plasmonic NH ‐MIL‐88@Pd nanozyme, an “on‐off” switch immunosensor constructed detection prostate‐specific antigen (PSA). Based multiple signal amplification effect, linear range PSA expanded three orders magnitude. The limit also improved from 1.44 × 10 −11 9.1 −13 g mL −1 . This work proposes effective method preparation provides new strategy sensitive cancer markers.

Language: Английский

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Overview of the Design and Application of Dual-Signal Immunoassays

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4551 - 4551

Published: Sept. 25, 2024

Immunoassays have been widely used for the determination of various analytes in fields disease diagnosis, food safety, and environmental monitoring. Dual-signal immunoassays are now advanced integrated detection technologies with excellent self-correction self-validation capabilities. In this work, we summarize recent advances development optical electrochemical dual-signal immunoassays, including colorimetric, fluorescence, surface-enhanced Raman spectroscopy (SERS), electrochemical, electrochemiluminescence, photoelectrochemical methods. This review particularly emphasizes working principle diverse utilization dual-functional molecules nanomaterials. It also outlines challenges prospects future research on immunoassays.

Language: Английский

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Multifunctional Nanozyme with Aptamer-Based Ratiometric Fluorescent and Colorimetric Dual Detection of Prostate-Specific Antigen

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

The adsorption of DNA probes onto nanomaterials represents a promising bioassay technique, generally employing fluorescence or catalytic activity to generate signals. A significant challenge is maintaining the chromogenic catalysts during detection while enhancing accuracy by overcoming limitations single-signal transmission. This article presents an innovative multimodal analysis approach that synergistically combines oxidase-like Fe–N–C nanozyme (Fe–NC) with red fluorescent carbon quantum dots (R–CQDs), further advancing dual-mode method utilizing R-CQDs@Fe–NC. In this system, R-CQDs integrate Fe–NC provide steady reference signal, serves as active site. 6-carboxyfluorescein-labeled aptamers (FAM-apt) significantly enhanced electron transfer capability R-CQDs@Fe–NC, its performance and resulting in increased oxidation 3,3′,5,5′-tetramethylbenzidine (TMB). Concurrently, green FAM-apt diminishes due energy competition, photoinduced transfer, internal filtration effect from R-CQDs@Fe–NC remains stable. Upon recognizing binding prostate-specific antigen (PSA), detaches surface leads simultaneous variations both signal system colorimetric TMB. Based on these properties, colorimetric/fluorescence for PSA was established, limits 0.054 0.16 ng/mL, respectively. Furthermore, smartphone-based sensing device facilitated rapid convenient detection. study multisignal output strategy simple capillary device, presenting diagnostic potential other biomarkers.

Language: Английский

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