Fluorescent nanosensors for the detection of hydrogen peroxide: Materials, design strategies and applications DOI

Yunxue Sun,

Lijie Xu, Xuetao Zhang

et al.

Dyes and Pigments, Journal Year: 2024, Volume and Issue: unknown, P. 112592 - 112592

Published: Dec. 1, 2024

Language: Английский

A Triple-Responsive and Dual-NIR Emissive Fluorescence Probe for Precise Cancer Imaging and Therapy by Activating Pyroptosis Pathway DOI
Min Deng,

Peipei Wang,

Zibo Zhai

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Revealing changes in the tumor microenvironment is crucial for understanding cancer and developing sensitive methods precise imaging diagnosis. Intracellular hydrogen peroxide (H2O2) microenvironmental factors (e.g., viscosity polarity) are closely linked to various physiological pathological processes, making them potential biomarkers cancer. However, a triple-response theranostic probe therapy has not yet been achieved due lack of effective tools. Herein, we present mitochondria-targeting near-infrared (NIR) fluorescent probe, VPH-5DF, capable simultaneously monitoring H2O2, viscosity, polarity through dual NIR channels. The specifically detects H2O2 via emission (λem = 650 nm) shows high sensitivity viscosity/polarity deep channel ≈ 750 nm). Furthermore, only monitors mitochondrial polarity, fluctuations endogenous/exogenous levels but also distinguishes cells from normal multiple parameters. Additionally, VPH-5DF can be employed monitor alterations levels, as well during drug-induced pyroptosis living cells. After treatment with chemotherapy-induced oxidative damage mitochondria activated pathway, leading robust antitumor response, evidenced xenograft models. Thus, this prodrug offers new platform vivo diagnosis anticancer chemotherapy.

Language: Английский

Citations

2
Dual-Mode Ratiometric Electrochemical and Turn-on Fluorescent Probe for Reliably Detecting H2O2 in Parkinson's Disease Serum DOI Creative Commons
Hui Dong,

Linlin Zheng,

Zuying Wang

et al.

Sensors and Actuators Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100305 - 100305

Published: Feb. 1, 2025

Language: Английский

Citations

2
A Hydrogen Peroxide Responsive Biotin-Guided Near-Infrared Hemicyanine-Based Fluorescent Probe for Early Cancer Diagnosis DOI Creative Commons

Lingyu Zhong,

Yingfei Wang,

Qing Hao

et al.

Chemosensors, Journal Year: 2025, Volume and Issue: 13(3), P. 104 - 104

Published: March 13, 2025

H2O2 plays an important role in oxidative damage and redox signaling. Studies have shown that abnormal levels of are closely related to the development cancer. The tumor cells higher than normal cells. Thus, it is great importance develop a fluorescent probe monitor level vivo. This work reports new biotin-guided NIR probe, Bio-B-Cy, consisting boronic acid ester as H2O2-recognition site biotin binding site, which accelerates fluorescence response Bio-B-Cy exhibits good sensitivity selectivity toward H2O2. In addition, shows dose-dependent detection limit 0.14 μM. We further demonstrate could successfully detect receptor-positive cancer tissues. Based on results, has potential serve efficient tool for early diagnosis

Language: Английский

Citations

1
Shortening the early diagnostic window of Hg2+-induced liver injury with a H2O2-activated fluorescence/afterglow imaging assay DOI
Longxuan Li, Jia Li, Xin Liu

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136059 - 136059

Published: Oct. 4, 2024

Language: Английский

Citations

3
Dual-Channel Fluorescent Probe for Simultaneously Visualizing ONOO- and Viscosity in Epilepsy, Non-Alcoholic Fatty Liver and Tumoral Ferroptosis Models DOI

Qi Zan,

Li Fan,

Rui Wang

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 282, P. 117495 - 117495

Published: April 17, 2025

Language: Английский

Citations

0
Small-molecule fluorescent probes for detecting hydrogen peroxide in biological systems DOI

Yongqing Zhou,

Xiao‐Feng Yang, Hosoowi Lee

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 541, P. 216785 - 216785

Published: May 17, 2025

Language: Английский

Citations

0
Fluorescence imaging in lung disease applications: A bibliometric and knowledge mapping analysis DOI Creative Commons

Jialian Lv,

Kang Zou,

Jie Wang

et al.

Asian Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

0
Fluorescent nanosensors for the detection of hydrogen peroxide: Materials, design strategies and applications DOI

Yunxue Sun,

Lijie Xu, Xuetao Zhang

et al.

Dyes and Pigments, Journal Year: 2024, Volume and Issue: unknown, P. 112592 - 112592

Published: Dec. 1, 2024

Language: Английский

Citations

0