Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(23)
Published: May 12, 2023
Helicobacter
pylori
(H.
pylori)
colonizes
the
stomach
epithelium
of
half
world's
population
and
is
responsible
for
various
digestive
diseases
even
cancer.
Vaccine-mediated
protection
against
H.
infection
depends
primarily
on
specific
mucosal
T-cell
responses.
In
this
study,
synthetic
lipopeptide
vaccines,
Hp4
(Pam2
Cys
modified
UreB
epitope)
Hp10
CagA
T/B
cell
combined
epitope),
not
only
induce
bone
marrow
derived
dendritic
cells
(BMDCs)
maturation
by
activating
a
variety
pattern-recognition
receptors
(PRRs)
such
as
Toll-like
receptor
(TLR),
Nod-like
(NLR),
retinoic
acid-inducing
gene
(RIG)
I-like
(RLR),
but
also
stimulate
BMDCs
to
secret
cytokines
that
have
potential
modulate
activation
differentiation.
Although
intranasal
immunization
with
or
elicits
robust
epitope-specific
responses
in
mice,
confers
infection,
possibly
due
fact
induces
substantial
sIgA
response
at
sites.
Interestingly,
elevates
protective
when
administrated
combination,
characterized
better
effect
enhanced
antibody
The
results
suggest
vaccines
based
epitopes
from
antigens
are
promising
candidates
infection.
Vaccines,
Journal Year:
2022,
Volume and Issue:
10(5), P. 819 - 819
Published: May 22, 2022
Vaccinations
are
one
of
the
most
important
preventive
tools
against
infectious
diseases.
Over
time,
many
different
types
vaccines
have
been
developed
concerning
antigen
component.
Adjuvants
essential
elements
that
increase
efficacy
vaccination
practises
through
actions,
especially
acting
as
carriers,
depots,
and
stimulators
immune
responses.
For
years,
few
adjuvants
included
in
vaccines,
with
aluminium
salts
being
commonly
used
adjuvant.
However,
recent
research
has
focused
its
attention
on
new
compounds
effective
adjuvant
properties
improved
safety.
Modern
technologies
such
nanotechnologies
molecular
biology
forcefully
entered
production
processes
both
components,
thereby
improving
vaccine
efficacy.
Microparticles,
emulsions,
currently
spotlight
for
their
huge
potential
production.
Although
studies
reported
some
side
effects
recently
recognised
ASIA
syndrome,
worth
remains
unquestionable.
Indeed,
COVID-19
pandemic
highlighted
importance
regard
to
managing
future
pandemics.
In
this
field,
into
could
play
a
leading
role
increasingly
vaccines.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(11), P. 2544 - 2544
Published: May 28, 2024
Surfactants,
also
known
as
surface-active
agents,
have
emerged
an
important
class
of
compounds
with
a
wide
range
applications.
However,
the
use
chemical-derived
surfactants
must
be
restricted
due
to
their
potential
adverse
impact
on
ecosystem
and
health
human
other
living
organisms.
In
past
few
years,
there
has
been
growing
inclination
towards
natural-derived
alternatives,
particularly
microbial
surfactants,
substitutes
for
synthetic
or
chemical-based
counterparts.
Microbial
biosurfactants
are
abundantly
found
in
bacterial
species,
predominantly
Bacillus
spp.
Pseudomonas
The
chemical
structures
involve
complexation
lipids
carbohydrates
(glycolipoproteins
glycolipids),
peptides
(lipopeptides),
phosphates
(phospholipids).
Lipopeptides,
particular,
subject
extensive
research
versatile
properties,
including
emulsifying,
antimicrobial,
anticancer,
anti-inflammatory
properties.
This
review
provides
update
progress
classification
surfactants.
Furthermore,
it
explores
various
functionalities,
along
advantages
over
Finally,
applications
these
many
industries
insights
into
future
directions
discussed.
ACS Applied Bio Materials,
Journal Year:
2022,
Volume and Issue:
5(3), P. 905 - 944
Published: Feb. 23, 2022
This
review
discusses
peptide
epitopes
used
as
antigens
in
the
development
of
vaccines
clinical
trials
well
future
vaccine
candidates.
It
covers
peptides
potential
immunotherapies
for
infectious
diseases
including
SARS-CoV-2,
influenza,
hepatitis
B
and
C,
HIV,
malaria,
others.
In
addition,
cancer
that
target
examples
overexpressed
proteins
are
summarized,
human
epidermal
growth
factor
receptor
2
(HER-2),
mucin
1
(MUC1),
folate
receptor,
The
uses
to
cancers
caused
by
infective
agents,
example,
cervical
papilloma
virus
(HPV),
also
discussed.
provides
an
overview
model
stimulate
non-specific
immune
responses,
self-adjuvanting
peptides,
influence
other
adjuvants
on
formulations.
As
highlighted
this
review,
several
advanced
vaccines,
there
is
great
therapies
due
specificity
response
can
be
achieved
using
epitopes.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(5), P. 1073 - 1073
Published: May 17, 2022
Nasal
drug
delivery
is
advantageous
when
compared
with
other
routes
of
as
it
avoids
the
hepatic
first-pass
effect,
blood-brain
barrier
penetration,
and
compliance
issues
parenteral
administration.
However,
nasal
administration
also
has
some
limitations,
such
its
low
bioavailability
due
to
metabolism
on
mucosal
surface,
irreversible
damage
mucosa
ingredients
added
into
formula.
Moreover,
method
not
applicable
all
drugs.
The
current
review
presents
anatomy
environment
for
vaccines
drugs,
well
various
methods
enhancing
absorption,
different
carriers
devices
improve
delivery.
It
future
prospects
Biotechnology Advances,
Journal Year:
2023,
Volume and Issue:
67, P. 108210 - 108210
Published: July 17, 2023
Lipopeptides
are
surface
active,
natural
products
of
bacteria,
fungi
and
green-blue
algae
origin,
having
diverse
structures
functionalities.
In
analogy,
a
number
chemical
synthesis
techniques
generated
new
designer
lipopeptides
with
desirable
features
functions.
Lipopetides
self-assembly
guided,
supramolecular
compounds
which
have
the
capacity
high-density
presentation
functional
epitopes
at
nanostructures.
This
feature
contributes
to
their
successful
application
in
several
industry
sectors,
including
food,
feed,
personal
care,
pharmaceutics.
this
comprehensive
review,
novel
class
ribosomally
synthesized
is
introduced
alongside
more
commonly
occuring
non-ribosomal
lipopeptides.
We
highlight
key
representatives
most
researched
as
well
recently
described
lipopeptide
families,
emphasis
on
structural
features,
associated
The
common
biological,
hybrid
production
routes
lipopeptides,
prominent
analogues
derivatives
also
discussed.
Furthermore,
genetic
engineering
strategies
aimed
increasing
yields,
diversity
biological
activity
summarized
exemplified.
With
respect
application,
work
mainly
details
potential
care
cosmetics
cleansing
agents,
moisturizer,
anti-aging/anti-wrinkling,
skin
whitening
preservative
agents
pharmaceutical
anitimicrobial
vaccines,
immunotherapy,
cancer
drugs.
Given
that
review
addresses
human
applications,
we
conclude
topic
safety
formulations
sustainable
production.
Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
158, P. 114117 - 114117
Published: Dec. 16, 2022
Peptide-based
vaccines,
which
form
one
of
the
most
potent
vaccine
platforms,
offer
exclusive
advantages
over
classical
vaccines
that
use
whole
organisms
or
proteins.
However,
peptides
alone
are
still
poor
stability
and
weak
immunogenicity,
thus
need
a
delivery
system
can
overcome
these
shortcomings.
Currently,
nanotechnology
has
been
extensively
utilized
to
address
this
issue.
Nanovaccines,
as
new
formulations
using
nanoparticles
(NPs)
carriers
adjuvants,
undergoing
development
instead
conventional
vaccines.
Indeed,
peptide-based
nanovaccine
is
rapidly
developing
field
research
emerging
out
confluence
antigenic
with
nano-delivery
system.
In
review,
we
shed
light
on
rational
design
preparation
strategies
based
various
nanomaterials
nanovaccines,
spotlight
progress
in
nanovaccines
against
cancer
infectious
diseases.
Finally,
future
prospects
for
presented.
