PubMed,
Journal Year:
2023,
Volume and Issue:
4(1), P. 5 - 17
Published: Jan. 1, 2023
Cancer
is
a
serious
concern
in
public
health
worldwide.
Numerous
modalities
including
surgery,
radiotherapy,
and
chemotherapy,
have
been
used
for
cancer
therapies
clinic.
Despite
progress
anticancer
therapies,
the
usage
of
these
methods
treatment
often
related
to
deleterious
side
effects
multidrug
resistance
conventional
drugs,
which
prompted
development
novel
therapeutic
methods.
Anticancer
peptides
(ACPs),
derived
from
naturally
occurring
modified
peptides,
received
great
attention
years
emerge
as
diagnostic
candidates
because
several
advantages
over
current
modalities.
In
this
review,
classification
properties
ACPs,
mode
action
mechanism
membrane
disruption,
well
natural
sources
bioactive
with
activities
were
summarised.
Because
their
high
efficacy
inducing
cell
death,
certain
ACPs
developed
work
drugs
vaccines,
evaluated
varied
phases
clinical
trials.
We
expect
that
summary
could
facilitate
understanding
design
increased
specificity
toxicity
towards
malignant
cells
reduced
normal
cells.
Acta Pharmaceutica Sinica B,
Journal Year:
2020,
Volume and Issue:
10(11), P. 2075 - 2109
Published: Oct. 13, 2020
In
many
ways,
cancer
cells
are
different
from
healthy
cells.
A
lot
of
tactical
nano-based
drug
delivery
systems
based
on
the
difference
between
and
Currently,
nanotechnology-based
most
promising
tool
to
deliver
DNA-based
products
This
review
aims
highlight
latest
development
in
lipids
polymeric
nanocarrier
for
siRNA
It
also
provides
necessary
information
about
its
mechanism
action.
Overall,
this
gives
us
a
clear
picture
lipid
polymer-based
systems,
which
future
could
form
base
translate
basic
biology
into
siRNA-based
therapies.
Journal of Polymer Science,
Journal Year:
2021,
Volume and Issue:
59(17), P. 1874 - 1898
Published: July 26, 2021
Abstract
The
self‐assembly
process
of
block
copolymers
(BCPs)
in
solution
has
been
at
the
focus
extended
scientific
research
over
past
several
decades
owing
to
astonishing
morphological
diversity
and
attainable
complexity
resulting
nanoassemblies,
including
spheres,
cylinders,
lamellae,
vesicles,
many
other
complex,
bicontinuous
or
even
hierarchical
structures.
ever‐increasing
sophistication
development
synthetic
chemistry
methods
techniques
led
a
myriad
available
macromolecules
with
varying
chemical
compositions,
architectures,
features,
properties.
This
assortment
characteristics
turn
plethora
intriguing
self‐organized
polymeric
nanostructures,
countless
possible
applications
nanotechnological
fields
relevant
physics,
chemistry,
material
science,
nanomedicine,
biomaterials.
present
review
aims
illuminate
importance
fascinating
potential
BCPs
by
highlighting
recent
advances
emerging
trends
field,
as
well
significant
application‐oriented
progress,
through
characteristic
contemporary
examples.
Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
13(10), P. 4025 - 4059
Published: June 30, 2023
Antibody‒drug
conjugates
(ADCs),
which
combine
the
advantages
of
monoclonal
antibodies
with
precise
targeting
and
payloads
efficient
killing,
show
great
clinical
therapeutic
value.
The
ADCs'
play
a
key
role
in
determining
efficacy
ADC
drugs
thus
have
attracted
attention
field.
An
ideal
payload
should
possess
sufficient
toxicity,
low
immunogenicity,
high
stability,
modifiable
functional
groups.
Common
include
tubulin
inhibitors
DNA
damaging
agents,
accounting
for
more
than
half
development.
However,
due
to
limitations
traditional
payloads,
such
as
inadequate
development
acquired
drug
resistance,
novel
highly
diverse
targets
reduced
side
effects
are
being
developed.
This
perspective
summarizes
recent
research
advances
main
focuses
on
structure-activity
relationship
studies,
co-crystal
structures,
designing
strategies,
further
discusses
future
directions
payloads.
review
also
aims
provide
valuable
references
that
will
efficacy,
adequate
abilities
overcome
resistance.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(46)
Published: Oct. 9, 2020
Abstract
Combining
intracellularly
active
proteins
with
chemotherapeutics
represents
a
promising
strategy
for
synergistic
cancer
therapy.
However,
the
lack
of
nanocarrier
systems
delivery
into
cells
and
controlled
intracellular
release
both
physicochemically
very
distinct
cargos
significantly
impedes
biomedical
translation
this
combination
in
Here,
well‐designed
triblock
copolymer,
mPEG‐
b
‐PGCA‐
‐PGTA,
is
reported
application
multistage
cooperative
drug
nanoplatform
that
accomplishes
effective
co‐delivery
hydrophilic
ribonuclease
A
(RNase
A)
hydrophobic
doxorubicin
(DOX).
RNase
bioreversibly
modified
phenylboronic
acid
groups
via
ROS‐cleavable
carbamate
linker
incorporated
copolymer
nanoparticles
high
efficiency
through
pH‐reversible
acid–catechol
linkage.
The
reversible
covalent
conjugations
between
endow
stability
under
normal
physiological
conditions.
Upon
cellular
internalization,
DOX
from
triggered
at
multiple
stages
by
endosomal
acidic
environment
subsequent
DOX‐enhanced
ROS
environment.
This
leads
to
enhanced
anticancer
effects
as
demonstrated
vitro
vivo.
Given
versatility
dynamic
conjugations,
work
provides
universal
stable
platform
various
combinations
chemotherapeutics.
Bioactive Materials,
Journal Year:
2020,
Volume and Issue:
6(7), P. 1878 - 1909
Published: Dec. 13, 2020
Poly(α-l-lysine)
(PLL)
is
a
class
of
water-soluble,
cationic
biopolymer
composed
α-l-lysine
structural
units.
The
previous
decade
witnessed
tremendous
progress
in
the
synthesis
and
biomedical
applications
PLL
its
composites.
PLL-based
polymers
copolymers,
till
date,
have
been
extensively
explored
contexts
such
as
antibacterial
agents,
gene/drug/protein
delivery
systems,
bio-sensing,
bio-imaging,
tissue
engineering.
This
review
aims
to
summarize
recent
advances
nanomaterials
these
fields
over
last
decade.
first
describes
derivatives,
followed
by
main
text
their
translational
studies.
Finally,
challenges
perspectives
are
addressed.
