Mesoporous carbons from self‐assembled polymers DOI
Mark Robertson, Moustafa M. Zagho, Sergei Nazarenko

et al.

Journal of Polymer Science, Journal Year: 2022, Volume and Issue: 60(14), P. 2015 - 2042

Published: April 11, 2022

Abstract Polymer self‐assembly provides a robust and cost‐efficient nanomanufacturing platform for enabling broad range of applications, such as microelectronics, drug delivery, separation membranes. This review focuses on discussing the progress opportunities self‐assembled polymer in synthesis mesoporous carbons (MCs), which have aroused significant research interests over past decades. Specifically, we will discuss two most established approaches converting nanostructured polymers to MCs, including templating‐based direct pyrolysis‐based methods. We also fundamental ordering mechanisms kinetics these polymeric systems recent development engineering methods providing on‐demand control pore size morphology MCs. Additionally, this article includes section focusing strategies further functionalize materials from enhance their performance, chemical activation, heteroatom doping, introduction nanoparticles into carbon matrix, enhancing graphitization degree walls. Finally, brief perspective is provided about emerging opportunity exciting field.

Language: Английский

Polymeric Nanoparticles for Drug Delivery DOI
Maximilian A. Beach,

Umeka Nayanathara,

Yanting Gao

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(9), P. 5505 - 5616

Published: April 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Language: Английский

Citations

272
Roadmap on photonic metasurfaces DOI
Sebastian A. Schulz, Rupert F. Oulton, Mitchell Kenney

et al.

Applied Physics Letters, Journal Year: 2024, Volume and Issue: 124(26)

Published: June 24, 2024

Here we present a roadmap on Photonic metasurfaces. This document consists of number perspective articles different applications, challenge areas or technologies underlying photonic Each will introduce the topic, state art as well give an insight into future direction subfield.

Language: Английский

Citations

49
Multistep, site-selective noncovalent synthesis of two-dimensional block supramolecular polymers DOI

Norihiko Sasaki,

Jun Kikkawa, Yoshiki Ishii

et al.

Nature Chemistry, Journal Year: 2023, Volume and Issue: 15(7), P. 922 - 929

Published: June 1, 2023

Language: Английский

Citations

48
Atom transfer radical polymerization DOI
Simon Harrisson, Richard Whitfield, Athina Anastasaki

et al.

Nature Reviews Methods Primers, Journal Year: 2025, Volume and Issue: 5(1)

Published: Jan. 9, 2025

Language: Английский

Citations

5
π-Conjugated-polymer-based nanofibers through living crystallization-driven self-assembly: preparation, properties and applications DOI
Junyu Ma, Guolin Lu, Xiaoyu Huang

et al.

Chemical Communications, Journal Year: 2021, Volume and Issue: 57(98), P. 13259 - 13274

Published: Jan. 1, 2021

π-Conjugated-polymer-based nanofibers endowed with both topological merits from fiber-like nanostructures and structural π-conjugated polymers represent one of the most exciting rapidly expanding fields.

Language: Английский

Citations

61
Self‐Immolative Amphiphilic Poly(ferrocenes) for Synergistic Amplification of Oxidative Stress in Tumor Therapy DOI
Jie Xu, Jiajia Tan,

Chengzhou Song

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(30)

Published: May 26, 2023

Abstract Amphiphilic self‐immolative polymers (SIPs) can achieve complete degradation solely through one triggerable event, which potentially optimize the blood clearance and uncontrollable/inert degradability for therapeutic nanoparticles. Herein, we report amphiphilic poly(ferrocenes), BP nbs ‐Fc , composed by backbone aminoferrocene (AFc) side chains as well end‐capping poly(ethylene glycol) monomethyl ether. Upon triggering tumor acidic milieu, nanoparticles readily degrade to release azaquinone methide (AQM) moieties, rapidly deplete intracellular glutathione (GSH) cascade AFc. Furthermore, both AFc its product Fe 2+ catalyze hydrogen peroxide (H 2 O ) into highly reactive hydroxyl radicals (⋅OH), thus amplifying oxidative stress of cells. Rational synergy GSH depletion ⋅OH burst efficiently inhibit growth SIPs in vitro vivo. This work provides an elegant design adopt innate milieu‐triggerable boost cellular stress, is a promising candidate precision medicine.

Language: Английский

Citations

28
Synthetic Cells Revisited: Artificial Cell Construction Using Polymeric Building Blocks DOI Creative Commons
Viviana Maffeis, Lukas Heuberger, Anamarija Nikoletić

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 11(8)

Published: Nov. 20, 2023

The exponential growth of research on artificial cells and organelles underscores their potential as tools to advance the understanding fundamental biological processes. bottom-up construction from a variety building blocks at micro- nanoscale, in combination with biomolecules is key developing cells. In this review, are focused upon based compartments where polymers main constituent assembly. Polymers particular interest due incredible chemical advantage tuning properties functionality assemblies. First, architectures nanoscale polymer assemblies introduced then usage elaborated upon. Different membrane-bound membrane-less supramolecular structures how they combine into advanced synthetic presented. Then, functional aspects explored, addressing giant mimic cellular Finally, communicate surrounding each other such adapt an ever-changing environment achieve collective behavior steppingstone toward tissues, taken look at. Engineering highly controllable programmable features open new avenues for development sophisticated multifunctional systems.

Language: Английский

Citations

27
Nanoscale polymer discs, toroids and platelets: a survey of their syntheses and potential applications DOI

Emma R. L. Brisson,

Max J. H. Worthington, Simran Kerai

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(4), P. 1984 - 2021

Published: Jan. 1, 2024

In this review, we focus on nanoscale polymer discs, toroids, and platelets. We illustrate design rules, group compositions discuss commonly used self-assembly strategies. summarise look ahead to potential applications of these nanomaterials.

Language: Английский

Citations

18
Structural Rheology in the Development and Study of Complex Polymer Materials DOI Open Access
Sergey O. Ilyin

Polymers, Journal Year: 2024, Volume and Issue: 16(17), P. 2458 - 2458

Published: Aug. 29, 2024

The progress in polymer science and nanotechnology yields new colloidal macromolecular objects their combinations, which can be defined as complex materials. complexity may include a complicated composition architecture of chains, specific intermolecular interactions, an unusual phase behavior, structure multi-component polymer-containing material. Determination relation between the material, properties its constituent elements, rheological material whole is subject structural rheology—a valuable tool for development study novel This work summarizes author’s structural–rheological studies materials determining conditions rheo-manifestations micro- nanostructuring. chemical chains role structuring via block segregation cooperative hydrogen bonds melt solutions considered using tri- multiblock styrene/isoprene vinyl acetate/vinyl alcohol copolymers. Specific molecular interactions are analyzed cellulose; acetate butyrate; gelatin/carrageenan combination; different acrylonitrile, oxadiazole, benzimidazole A homogeneous result from conformational transition, mesophase formation, or association caused by chain inter- supramolecular which, however, masked entanglements when behavior. heterogeneous formation implies microscopic separation upon non-solvent addition, temperature change, intense shear up to macroscopic decomposition. polymer/particle have been examined polyethylene oxide solutions, polyisobutylene melts, cellulose gels containing solid particles nature, demonstrating competition entanglements, interparticle adsorption governing properties. Complex has long-chain branched polybutylene-adipate-terephthalate cross-linked sodium hyaluronate hydrogels, asphaltene linear/highly-branched polydimethylsiloxane blends, showing that branching raises viscosity elasticity limited miscibility with linear isomonomer chains. Finally, some examples composite adhesives, membranes, greases structured polymeric functional presented demonstration performance

Language: Английский

Citations

16
Block copolymer micelles as ocular drug delivery systems DOI Creative Commons
Ahmad A. Assiri, Katie Glover, Deepakkumar Mishra

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(8), P. 104098 - 104098

Published: July 10, 2024

Block copolymer micelles, formed by the self-assembly of amphiphilic polymers, address formulation challenges, such as poor drug solubility and permeability. These micelles offer advantages including a smaller size, easier preparation, sterilization, superior solubilization, compared with other nanocarriers. Preclinical studies have shown promising results, advancing them toward clinical trials. Their mucoadhesive properties enhance prolong contact ocular surface, their small size allows deeper penetration through tissues, cornea. Additionally, copolymeric improve stability hydrophobic drugs, sustain release, allow for surface modifications to biocompatibility. Despite these benefits, long-term remains challenge. In this review, we highlight preclinical performance, structural frameworks, preparation techniques, physicochemical properties, current developments, prospects block delivery systems.

Language: Английский

Citations

12