Biomacromolecules,
Journal Year:
2022,
Volume and Issue:
23(4), P. 1581 - 1591
Published: March 10, 2022
Posterior
capsular
opacification
(PCO)
is
a
primary
complication
after
phacoemulsification
combined
with
intraocular
lens
(IOL)
implantation,
which
attributed
to
adhesion,
proliferation,
and
migration
of
residual
epithelial
cells
on
IOL.
Although
surface
hydrophilic
coating
considered
be
powerful
way
inhibit
PCO
incidence
surgery,
it
requires
complex
post-production
processes,
thus
limiting
their
applicability.
In
comparison,
bulk
modification
stable,
effective,
facile
IOL
synthesis
method
for
prevention.
Herein,
new
anti-adhesive
material
was
designed
successfully
synthesized
by
radical
copolymerization
ethylene
glycol
phenyl
ether
methacrylate
(EGPEMA)
2-(2-ethoxyethoxy)
ethyl
acrylate
(EA).
The
physicochemical
properties
P(EGPEMA-co-EA)
copolymer
materials,
including
chemical
structure,
mechanical,
thermal,
surface,
optical
properties,
were
analyzed
using
1H
NMR
spectroscopy,
FT-IR
tensile
test,
thermogravimetric
analysis
(TGA),
differential
scanning
calorimetry
(DSC),
water
contact
angle
measurement,
UV–vis
spectroscopy.
elongation
at
break
the
modulus
elasticity
tunable
through
change
composition
monomers.
Compared
other
components,
results
showed
that
materials
(70%
EGPEMA
in
mass
ratio,
F7)
are
suitable
preparation
foldable
lower
elastic
higher
break.
TGA
DSC
has
high
thermal
stability,
glass
transition
temperature
F7
16.1
°C.
measurement
introduction
EA
improved
hydrophilicity
material.
percentage
transmittance
all
copolymers
400–800
nm
above
85%.
Then,
biocompatibility
evaluated
vitro
assay
subcutaneous
implantation.
Both
implantation
experiments
exhibited
good
anti-adhesion
effect
no
cytotoxicity.
Finally,
performed,
vivo
confirmed
prevention
ability
as
well
materials.
Materials,
Journal Year:
2024,
Volume and Issue:
17(14), P. 3454 - 3454
Published: July 12, 2024
This
paper
reviews
the
latest
trends
and
applications
of
silicone
in
ophthalmology,
especially
related
to
intraocular
lenses
(IOLs).
Silicone,
or
siloxane
elastomer,
as
a
synthetic
polymer,
has
excellent
biocompatibility,
high
chemical
inertness,
hydrophobicity,
enabling
wide
biomedical
applications.
The
physicochemical
properties
are
reviewed.
A
review
methods
for
mechanical
vivo
characterization
IOLs
is
presented
prospective
research
area,
since
there
only
few
available
technologies,
even
though
these
vital
ensure
medical
safety
suitability
clinical
use,
if
long-term
function
considered.
represent
permanent
implants
replace
natural
lens
correcting
vision,
with
first
commercial
foldable
made
silicone.
Biological
aspects
posterior
capsular
opacification
have
been
reviewed,
including
effects
implanted
IOL.
However,
certain
issues
still
challenging
some
conditions
can
prevent
its
application
all
patients.
nanotechnology
solutions
Surface
modifications
an
efficient
approach
further
improve
biocompatibility
enable
drug-eluting
function.
Different
surface
modifications,
coatings,
provide
treatments
various
diagnoses
through
incorporation
sensory
functions.
It
essential
that
IOL
optical
characteristics
remain
unchanged
case
drug
nanoparticles
it.
trials
advanced
technologies
missing,
thus
preventing
their
at
this
moment.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 29, 2024
Injectable
biomaterials
have
been
engineered
to
operate
within
the
human
body,
offering
versatile
solutions
for
minimally
invasive
therapies
and
meeting
several
stringent
requirements
such
as
biocompatibility,
biodegradability,
low
viscosity
ease
of
injection,
mechanical
strength,
rapid
gelation
postinjection,
controlled
release
therapeutic
agents,
hydrophobicity/hydrophilicity
balance,
stability
under
physiological
conditions,
ability
be
sterilized.
Their
adaptability
performance
in
diverse
clinical
settings
make
them
invaluable
modern
medical
treatments.
This
article
reviews
recent
advancements
design,
synthesis,
characterization
injectable
polymeric
biomaterials,
providing
insights
into
their
emerging
applications.
We
discuss
a
broad
spectrum
these
materials,
including
natural,
synthetic,
hybrid,
composite
types,
that
are
being
applied
targeted
drug
delivery,
cell
protein
transport,
regenerative
medicine,
tissue
adhesives,
implants,
bioimaging,
diagnostics,
3D
bioprinting.
Ultimately,
review
highlights
critical
role
shaping
future
treatments
improving
patient
outcomes
across
wide
range
diagnostic
Biomacromolecules,
Journal Year:
2022,
Volume and Issue:
23(4), P. 1581 - 1591
Published: March 10, 2022
Posterior
capsular
opacification
(PCO)
is
a
primary
complication
after
phacoemulsification
combined
with
intraocular
lens
(IOL)
implantation,
which
attributed
to
adhesion,
proliferation,
and
migration
of
residual
epithelial
cells
on
IOL.
Although
surface
hydrophilic
coating
considered
be
powerful
way
inhibit
PCO
incidence
surgery,
it
requires
complex
post-production
processes,
thus
limiting
their
applicability.
In
comparison,
bulk
modification
stable,
effective,
facile
IOL
synthesis
method
for
prevention.
Herein,
new
anti-adhesive
material
was
designed
successfully
synthesized
by
radical
copolymerization
ethylene
glycol
phenyl
ether
methacrylate
(EGPEMA)
2-(2-ethoxyethoxy)
ethyl
acrylate
(EA).
The
physicochemical
properties
P(EGPEMA-co-EA)
copolymer
materials,
including
chemical
structure,
mechanical,
thermal,
surface,
optical
properties,
were
analyzed
using
1H
NMR
spectroscopy,
FT-IR
tensile
test,
thermogravimetric
analysis
(TGA),
differential
scanning
calorimetry
(DSC),
water
contact
angle
measurement,
UV–vis
spectroscopy.
elongation
at
break
the
modulus
elasticity
tunable
through
change
composition
monomers.
Compared
other
components,
results
showed
that
materials
(70%
EGPEMA
in
mass
ratio,
F7)
are
suitable
preparation
foldable
lower
elastic
higher
break.
TGA
DSC
has
high
thermal
stability,
glass
transition
temperature
F7
16.1
°C.
measurement
introduction
EA
improved
hydrophilicity
material.
percentage
transmittance
all
copolymers
400–800
nm
above
85%.
Then,
biocompatibility
evaluated
vitro
assay
subcutaneous
implantation.
Both
implantation
experiments
exhibited
good
anti-adhesion
effect
no
cytotoxicity.
Finally,
performed,
vivo
confirmed
prevention
ability
as
well
materials.
