International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 660, P. 124344 - 124344
Published: June 15, 2024
Language: Английский
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(16)
Published: Feb. 24, 2024
Abstract Most tissues of the human body present hierarchical fibrillar extracellular matrices (ECMs) that have a strong influence over their physicochemical properties and biological behavior. Of great interest is introduction this structure to hydrogels, particularly due water‐rich composition, cytocompatibility, tunable class biomaterials. Here, main bottom‐up fabrication strategies for design production biomimetic hydrogels most representative applications in fields tissue engineering regenerative medicine are reviewed. For example, controlled assembly/arrangement peptides, polymeric micelles, cellulose nanoparticles (NPs), magnetically responsive nanostructures, among others, into discussed, as well potential use fibrillar‐like (e.g., those from NPs) with key biofunctionalities such electrical conductivity or remote stimulation. Finally, major remaining barriers clinical translation future directions research field discussed.
Language: Английский
Citations
12
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140442 - 140442
Published: Jan. 1, 2025
Language: Английский
Citations
1
Nanoscale, Journal Year: 2024, Volume and Issue: 16(38), P. 17699 - 17722
Published: Jan. 1, 2024
This review explores recent advances in the development of cancer immunotherapy using nanoparticles for tumor vaccine, stimulating specific T cells, and delivering immuno-activation modulatory agents to activate cytotoxic cells.
Language: Английский
Citations
4
ACS Macro Letters, Journal Year: 2025, Volume and Issue: unknown, P. 679 - 686
Published: May 9, 2025
Peptide self-assembly has been used to fabricate synthetic hydrogels that emulate many of the chemical and physical properties natural hydrogels. However, these materials often lack stability for applications do not display native bioactivity found in tissue. Here we demonstrate a hybrid hydrogel system which self-assembling peptides are integrated with polysaccharides enhance gelation provide improved mechanics bioactivity. A peptide based on tryptophan zipper (trpzip) motif was mixed anionic polysaccharide gellan gum, demonstrating within minutes increased stiffness compared trpzip alone. The material maintained viscoelastic character shear-thinning, self-healing, stress-relaxation order like collagen. All supported cell adhesion viability gum content, promoting assembly into aggregates. enhanced kinetics, stability, make them promising candidates as matrices culture reagents biofabrication syringe extrusion biological delivery.
Language: Английский
Citations
0
Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(9), P. 5918 - 5927
Published: Aug. 19, 2024
Macrophages play crucial roles in the innate immune response, exhibiting context-dependent behaviors. Within tumor microenvironment, macrophages exist as tumor-associated or M2-like macrophages, presenting reprogramming challenges. In this study, we develop a peptide hydrogel that is able to polarize M0 into pro-inflammatory M1 through activation of NF-κB signaling pathways. Importantly, system also found be capable M2 M1-like by activating CD206 receptors. The nanofibrous self-assembles from short contains an defense regulator and self-assembly promoting motif, densely arrayed regulators multivalently engage with macrophage membrane receptors not only but repolarize macrophages. Overall, work offers promising strategy for holding potential enhance immunotherapy remodeling immune-resistant microenvironments.
Language: Английский
Citations
2
Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(11), P. 6967 - 6986
Published: Oct. 17, 2024
Supramolecular peptide hydrogels (SPHs) consist of peptides containing hydrogelators and functional epitopes, which can first self-assemble into nanofibers then physically entangle together to form dynamic three-dimensional networks. Their porous structures, excellent bioactivity, high dynamicity, similar an extracellular matrix (ECM), have great potential in artificial ECM. The properties the hydrogel are largely dependent on peptides. noncovalent interactions among drive formation assemblies further transition hydrogels, while bioactive epitopes modulate cell-cell cell-ECM interactions. Therefore, SPHs support cell growth, making them ideal biomaterials for ECM mimics. This Review outlines classical molecular design from summarizes recent advancements as ECMs nervous system repair, wound healing, bone cartilage regeneration, organoid culture. emerging SPH platform could provide alternative strategy developing more effective tissue engineering.
Language: Английский
Citations
1
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 660, P. 124344 - 124344
Published: June 15, 2024
Language: Английский
Citations
0