Construction of Nanohydroxyapatite/Poly(sodium lipoate)-Based Bioactive Hydrogels for Cranial Bone Regeneration DOI

Jiaqiang Du,

Tingting Chen, Jing Yu

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 26(1), P. 705 - 714

Published: Dec. 28, 2024

Persistent oxidative stress following bone defects significantly impedes the repair of tissue. Designing an antioxidative hydrogel with a suitable mechanical strength can help alter local microenvironment and promote defect healing. In this work, α-lipoic acid (LA), natural antioxidant small molecule, was chemically cross-linked lipoic acid-functionalized poly(ethylene glycol) (PEGx, x = 6k or 10k) in sodium bicarbonate solution, to prepare LA-PEGx hydrogels (LPx, 10k). Furthermore, nanohydroxyapatite (nHA)-LA-PEGx (HLPx, 6k) were constructed through incorporating nHA. The exhibited moderate strength, facile injectability, self-healability, adhesion, biodegradability, biocompatibility, promising antioxidation efficiency. We verify advantage HLP6k-3 rat cranial model. Through regulation reactive oxygen species (ROS), osteoconduction, biomineralization capabilities, our system new formation. Overall, bioactive multiple functions hold significant promise for repairing defects.

Language: Английский

Exploring advancements in polysaccharide-based approaches: The cornerstone of next-generation cartilage regeneration therapeutics DOI
Noella Abraham,

Giriraj Pandey,

Tejaswini Kolipaka

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141352 - 141352

Published: Feb. 1, 2025

Language: Английский

Citations

2
Structural characterization and chondroprotective activity evaluation of four novel polysaccharides purified from Anoectochilus zhejiangensis on transgenic fluorescent zebrafish DOI
Tao Yi, Lisha Shen, Wei Luo

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123319 - 123319

Published: Jan. 1, 2025

Language: Английский

Citations

1
Polysaccharide base electrospun nanofibrous scaffolds for cartilage tissue engineering: Challenges and opportunities DOI

Atefeh Arash,

Fatemeh Dehgan,

Soheila Zamanlui Benisi

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134054 - 134054

Published: July 20, 2024

Language: Английский

Citations

6
Design, Characterization, and Biocompatibility of Modular Biopolymer-Based Single- and Double-Cross-Linked Networks Hydrogels DOI
Dipankar Das,

Aysha Awan,

Kawaljit Kaur

et al.

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: 6(21), P. 13158 - 13170

Published: Oct. 31, 2024

The synthesis of the modular ketone-rich dextrin acetoacetate (DXTAA) and its application in click chemistry-based single-cross-linked network (SN) double-cross-linked (DN) biopolymeric hydrogels are reported. DXTAA is obtained a base-catalyzed transesterification reaction between tert-butyl acetoacetate. forms covalently cross-linked SN with hydrazide derivative alginate (Alg-SDH) via hydrazone linkages aqueous solution without any initiator, heat, or catalyst. presence carboxylate groups Alg-SDH enables preparation DN using calcium ions as an ionic cross-linker. swelling ratio stability shown to be pH-dependent; hydrogel exhibits considerably higher at pH 7.4 compared hydrogel. Both noncytotoxic biocompatible. Thus, can considered promising cross-linker for situ biocompatible gel.

Language: Английский

Citations

3
Hydrogels Empowered Mesenchymal Stem Cells and the Derived Exosomes for Regenerative Medicine in Age-Related Musculoskeletal Diseases DOI Creative Commons
Lixin Liu,

Siwen Chen,

Yingfang Song

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107618 - 107618

Published: Jan. 1, 2025

Language: Английский

Citations

0
Construction of Cells‐Membrane‐Cells Living Complexes for Cartilage Repair by Enhancing the Structural Stability of Fibrous Membranes DOI

Yan‐Ru Hu,

Lihui Meng, Wenchao Li

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract 3D cartilage tissue engineering scaffolds with stable structures are crucial for promoting growth and repair. However, limited research attention is given to the effects of cells‐membrane‐cells sandwich‐like living complexes enhanced structural stability In this study, silk fibroin/graphene oxide@kartogenin (SF/GO@KGN) fibrous membranes improved developed through regulation crystallinity, constructed repair using rat bone marrow stromal cells (rBMSCs) SF/GO@KGN membranes. Results show that physicochemical properties membranes, including morphology, tensile strength, swelling ratio, degradation, KGN release rate greatly influenced by crystallinity The promotes adhesion, proliferation, chondrogenic differentiation rBMSCs on surface as well deposition cartilage's extracellular matrix (ECM). Animal experiments demonstrate high significantly promote early formation ECM deposition. This study not only provides a facile effective strategy regeneration but also new insights designing preparing other scaffolds.

Language: Английский

Citations

0
Construction and performance evaluation of fully biomimetic hyaline cartilage matrix scaffolds for joint defect regeneration DOI
Haidi Sun,

Zhonglian Wu,

Lihua Liu

et al.

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(6), P. 065035 - 065035

Published: Oct. 17, 2024

Due to the absence of nerves and blood vessels in articular cartilage, its regeneration repair present a significant complex challenge osteoarthritis treatment. Developing specialized physical chemical microenvironment supporting cell growth has been difficult cartilage grafting, especially when aiming for comprehensive biomimetic solutions. Based on previous research, we have designed tissue-engineered decellularized living hyaline graft (dLhCG). The study developed method improve hydrophilicity stiffness scaffolds by employing grafting techniques phenotype matrix scaffold tissue engineering. Here, reported using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride /N-hydroxysuccinimide (EDC/NHS) achieve chondroitin sulfate (CS) onto dLhCG, ultimately producing with CS (dLhCG/CS). Young's modulus measurements revealed that cross-linked exhibited enhanced mechanical properties. We implanted dLhCG/CS into trochlear region rat joints evaluated their functionality through histological analysis biomechanical tests. After 12 weeks, demonstrated excellent bioinductive activity comparable dLhCG. regenerated effectively maintained similar properties, playing crucial role regeneration.

Language: Английский

Citations

2
Metal-organic frameworks (MOFs) and their derivatives as emerging biomaterials for the treatment of osteoarthritis DOI Creative Commons

Yufu Liu,

Hongwei Zhang, Tianyan Chen

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 18, 2024

As a novel class of smart biomaterials with promising potentials, metal-organic frameworks (MOFs) are widely utilized in the field biomedicine. Current researches indicate that therapeutic strategies for osteoarthritis (OA) highly limited to achieving symptom improvement and reducing both pain inflammation. Together, introduction MOFs into treatment OA holds potential offer significant benefits. This is because not only have intrinsic biological activities, but also act as carriers facilitate controlled drug delivery prolong duration management OA. paper presents review recent studies explored usage drugs or OA, which examines progress tissue engineering These anticipated enhance comprehension provide strong evidence favor their utilization

Language: Английский

Citations

0
Advancing Cartilage Tissue Engineering: A Review of 3D Bioprinting Approaches and Bioink Properties DOI
Gabriele Boretti,

Arsalan Amirfallah,

Kyle J. Edmunds

et al.

Tissue Engineering Part B Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Articular cartilage is crucial in human physiology, and its degeneration poses a significant public health challenge. While recent advancements 3D bioprinting tissue engineering show promise for regeneration, there remains gap between research findings clinical application. This review critically examines the mechanical biological properties of hyaline cartilage, along with current manufacturing methods analysis techniques. Moreover, we provide quantitative synthesis bioink used engineering. After screening 181 initial works, 33 studies using extrusion were analyzed synthesized, presenting results that indicate main materials, cells, utilized evaluation. Altogether, this motivates standardization analyses biomaterial assessments bioprinted constructs to clarify their chondrogenic potential.

Language: Английский

Citations

0
Construction of Nanohydroxyapatite/Poly(sodium lipoate)-Based Bioactive Hydrogels for Cranial Bone Regeneration DOI

Jiaqiang Du,

Tingting Chen, Jing Yu

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 26(1), P. 705 - 714

Published: Dec. 28, 2024

Persistent oxidative stress following bone defects significantly impedes the repair of tissue. Designing an antioxidative hydrogel with a suitable mechanical strength can help alter local microenvironment and promote defect healing. In this work, α-lipoic acid (LA), natural antioxidant small molecule, was chemically cross-linked lipoic acid-functionalized poly(ethylene glycol) (PEGx, x = 6k or 10k) in sodium bicarbonate solution, to prepare LA-PEGx hydrogels (LPx, 10k). Furthermore, nanohydroxyapatite (nHA)-LA-PEGx (HLPx, 6k) were constructed through incorporating nHA. The exhibited moderate strength, facile injectability, self-healability, adhesion, biodegradability, biocompatibility, promising antioxidation efficiency. We verify advantage HLP6k-3 rat cranial model. Through regulation reactive oxygen species (ROS), osteoconduction, biomineralization capabilities, our system new formation. Overall, bioactive multiple functions hold significant promise for repairing defects.

Language: Английский

Citations

0