Endothelium-Inspired Hemocompatible Silicone Surfaces: An Elegant Balance between Antifouling Properties and Endothelial Cell Selectivity DOI

Qiulian Wu,

Shuaihang Guo,

Xinyi Liang

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(11), P. 7202 - 7215

Published: Aug. 27, 2024

To address the adverse reactions caused by implantation of blood-contacting materials, researchers have developed different strategies, which mimicking multiple key features endothelial cells is most effective. However, simultaneously immobilizing chemical components on a single material surface and maintaining effects individual are challenging. In this work, endothelium-mimicking silicone surfaces were incorporating antifouling polymer poly(oligo(ethylene glycol) methacrylate), glycosaminoglycan analog poly(sodium 4-vinyl-benzenesulfonate) nitric oxide catalyst (selenocystamine dihydrochloride). Through rational regulation components, harmoniously resisted nonspecific protein adsorption, platelet adhesion activation smooth muscle cell hyperproliferation while promoting proliferation migration. The coculture experiment with HUVECs HUVSMCs showed that optimum selectivity HUVECs/HUVSMCs was ∼1.7. This work contributes insight into control properties selectivity, providing new avenue for development materials.

Language: Английский

3D printed sodium Alginate-Gelatin hydrogel loaded with Santalum album oil as an antibacterial Full-Thickness wound healing and scar reduction Scaffold: In vitro and in vivo study DOI

Shahabaj S Mujawar,

Gajanan K Arbade,

Sonali Rukwal

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125164 - 125164

Published: Jan. 5, 2025

Language: Английский

Citations

1
Multimechanism Long-Term Antibacterial Coating with Simultaneous Antifouling, Contact-Active, and Release-Kill Properties DOI

Jui-Lin Wang,

Song Wang,

Pian Zhong

et al.

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: 6(10), P. 5726 - 5737

Published: May 15, 2024

Catheter-related infections are some of the most common acquired in hospitals, and designing functional coatings on surface medical catheters to limit bacterial colonization biofilm formation can be effective avoiding infections. In this study, a composite coating (PU-PDA-Ag-PDA-PHMG) with simultaneous antifouling, contact-active, release-kill properties was prepared polyurethane (PU) surfaces using polydopamine, Ag nanoparticles, polyhexamethylene guanidine. This systematically evaluated by studying its long-term hydrophilicity, antibacterial property, antibiofilm silver release rate, mechanical biocompatibility. The results scanning electron microscopy, atomic force Fourier transform infrared spectrometry, X-ray photoelectron spectroscopy showed that PU-PDA-Ag-PDA-PHMG multimechanism successfully PU surface. Relative value 97.62° for unmodified substrate, water contact angle increased from 49.73° 61.68° after 28 days deionized immersion, indicating excellent hydrophilic properties. Also, reduces protein adhesion 58.67%. After immersion PBS solution, rates against Staphylococcus aureus Escherichia coli still reached 97.67% 99.5%, respectively, broad-spectrum property significantly improved compared single-mechanism coating, almost free any bacteria. total amount ions released about 16.95% PU-PDA-Ag within 14 days, which proved could reduce rate ions. preparation process also did not change original biocompatibility (cytotoxicity level 1). conclusion, developed study has great potential reducing catheter-associated

Language: Английский

Citations

5
Biofilm formation in cardiovascular infection and bioengineering approaches for treatment and prevention DOI Creative Commons
Qi Tong,

Qiyue Xu,

Jie Cai

et al.

MedComm – Biomaterials and Applications, Journal Year: 2025, Volume and Issue: 4(1)

Published: Jan. 31, 2025

Abstract At present, cardiovascular infection such as infective endocarditis (IE) has become a major disease with high mortality rate. The essence of IE is actually the associated biofilm formation, which can occur not only on native heart valves, but also prosthetic valves and implants left assist devices, vascular grafts, pacemakers. Biofilms are bacterial aggregates that composed self‐produced extracellular polymeric substance (EPS), difficult challenging for treatment infections. Therefore, it important to explore develop effective anti‐biofilm methods biofilm‐associated infection. This review provides comprehension strategies degrading EPS in biofilm, application nanodrug delivery systems biofilm‐related infections, strategy targeting drug resistance genes through gene editing technology quorum sensing biofilm. Furthermore, this some optimize antibacterial properties prevent formation. applications these will provide novel preventive therapeutic ways

Language: Английский

Citations

0
Mussel-Inspired Hydrogel Applied to Wound Healing: A Review and Future Prospects DOI Creative Commons

Yanai Chen,

Yijia Cao,

Peixin Cui

et al.

Biomimetics, Journal Year: 2025, Volume and Issue: 10(4), P. 206 - 206

Published: March 26, 2025

The application background of mussel-inspired materials is based on the unique underwater adhesive ability marine mussels, which has inspired researchers to develop bionic with strong adhesion, self-healing ability, biocompatibility, and environmental friendliness. Specifically, 3, 4-dihydroxyphenylalanine (DOPA) in mussel byssus able form non-covalent forces a variety surfaces, are critical for mussel's adhesion enable material dissipate energy repair itself under external forces. Mussel-inspired hydrogels ideal medical due their physical chemical properties, such as excellent tissue hemostasis bacteriostasis, biosafety, plasticity. This paper reviewed chitosan, cellulose, hyaluronic acid, gelatin, alginate, other biomedical discussed advanced functions wound dressings, including antibacterial, anti-inflammatory, antioxidant hemostasis, transport, self-healing, stimulating response, so on. At same time, technical challenges limitations biomimetic hydrogel applications were further discussed, its potential solutions future research developments field biomedicine highlighted.

Language: Английский

Citations

0
Recent advances in gel coatings: from lab to industry DOI
Lingling Zhang, Yujin Hu, Li‐Wei Wu

et al.

Journal of Materials Chemistry A, Journal Year: 2024, Volume and Issue: 12(30), P. 18901 - 18920

Published: Jan. 1, 2024

The review summarizes and categorizes innovative gel synthesis methods coating fabrication techniques with robust interfacial adhesion, focusing on the strategies of user eco-friendliness in versatile scenarios.

Language: Английский

Citations

3
Endothelium-Inspired Hemocompatible Silicone Surfaces: An Elegant Balance between Antifouling Properties and Endothelial Cell Selectivity DOI

Qiulian Wu,

Shuaihang Guo,

Xinyi Liang

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(11), P. 7202 - 7215

Published: Aug. 27, 2024

To address the adverse reactions caused by implantation of blood-contacting materials, researchers have developed different strategies, which mimicking multiple key features endothelial cells is most effective. However, simultaneously immobilizing chemical components on a single material surface and maintaining effects individual are challenging. In this work, endothelium-mimicking silicone surfaces were incorporating antifouling polymer poly(oligo(ethylene glycol) methacrylate), glycosaminoglycan analog poly(sodium 4-vinyl-benzenesulfonate) nitric oxide catalyst (selenocystamine dihydrochloride). Through rational regulation components, harmoniously resisted nonspecific protein adsorption, platelet adhesion activation smooth muscle cell hyperproliferation while promoting proliferation migration. The coculture experiment with HUVECs HUVSMCs showed that optimum selectivity HUVECs/HUVSMCs was ∼1.7. This work contributes insight into control properties selectivity, providing new avenue for development materials.

Language: Английский

Citations

3