Mechanical
grinding
of
molecules,
a
straightforward
yet
efficient
chemical
reaction
technique,
now
has
established
the
field
mechanochemistry.
While
many
physicochemical
behaviors
upon
mechanical
have
been
revealed,
its
application
on
vapor-phase
cocrystallization
not
demonstrated.
In
this
work,
we
show
that
can
encourage
sublimation,
which
is
highly
demanded
for
successful
synthesis
molecular
cocrystals
by
physical
vapor
transport
(PVT)
process.
When
mixture
fluoranthene
(FA)
and
tetracyanoquinodimethane
(TCNQ)
powders
ground
together
used
as
precursor,
PVT
at
170
°C
results
in
large,
thin
belt-shaped
FA-TCNQ
with
high
selectivity
yield.
contrast,
simple
FA
TCNQ
mostly
irregular
crystals
negligible
yield
due
to
dominance
vapors
°C.
Thermogravimetric
analysis
reduced
sublimation
temperatures
both
after
grinding,
responsible
formation
cocrystals.
We
believe
study
opens
new
chapter
provides
understanding
effect
grinding.
Journal of drug targeting,
Journal Year:
2024,
Volume and Issue:
32(2), P. 115 - 127
Published: Jan. 2, 2024
Pharmaceutical
cocrystals,
owing
to
their
manifold
applications,
are
acting
as
bridge
between
drug
discovery
and
pharmaceutical
product
development.
The
ability
scale
up
cocrystals
through
continuous
manufacturing
approaches
offers
superior
economic
products.
Moreover,
can
be
an
aid
for
the
nanoparticulate
systems
solve
issues
related
scale-up
cost.
Cocrystals
grabbed
attention
of
academic
researchers
scientist
due
potential
target
various
diseases
like
cancer.
present
review
is
mainly
focussed
on
diverse
comprehensive
applications
in
delivery
including
solubility
dissolution
enhancement,
improvement
bioavailability
drug,
mechanical
flow
properties
active
ingredients,
controlled/sustained
release
colour
tuning
API.
Besides,
phytochemical
based
multi-drug
tumour
therapy
have
been
discussed
this
review.
Additionally,
recent
progress
pertinent
also
included,
which
may
provide
future
directions
cocrystals.
Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(5), P. 2577 - 2589
Published: April 22, 2024
This
study
aimed
to
repurpose
the
antifungal
drug
flucytosine
(FCN)
for
anticancer
activity
together
with
cocrystals
of
nutraceutical
coformers
sinapic
acid
(SNP)
and
syringic
(SYA).
The
cocrystal
screening
experiments
SNP
resulted
in
three
hydrate
forms
which
two
are
polymorphs,
namely,
FCN-SNP
F-I
F-II,
third
one
different
stoichiometry
asymmetric
unit
(1:2:1
ratio
FCN:SNP:H
Crystal Growth & Design,
Journal Year:
2024,
Volume and Issue:
24(11), P. 4652 - 4667
Published: May 15, 2024
Understanding
drug
cocrystal
formation
and
its
competitive
mechanism
is
important
for
improving
the
physicochemical
properties
of
drugs.
In
this
article,
polyhydroxy
natural
products
their
mechanisms
are
discussed
through
experimental
screening
theoretical
calculations.
The
conditions
types
cocrystals
were
determined
based
on
efficient
experiments
product
cocrystals.
To
investigate
difficulty
stability
formation,
carried
out
simultaneously.
By
simulation
electrostatic
potential
surface
molecules
Hirshfeld
crystals,
mode
hydrogen
bonding
within
crystals
was
determined.
strength
assessed
intermolecular
interactions
energy
framework
crystal
structure.
A
"substitution
model"
constructed
results
calculations,
which
great
significance
prediction
design
provides
a
feasible
solution
European Journal of Pharmaceutical Sciences,
Journal Year:
2025,
Volume and Issue:
209, P. 107115 - 107115
Published: April 30, 2025
Secnidazole
is
a
second
generation
5-nitroimidazole
with
high
potential
for
application
in
anaerobic
periodontal
infections
therapy.
In
this
study,
the
process
of
developing
drug-loaded
films
composed
oppositely
charged
chitosan
and
pectin
intra-pocket
administration
presented.
Due
to
limitations
layer-by-layer
technique
receiving
systems
type,
which
resulted
from
spontaneous
crystallization
secnidazole
at
stage
drying,
new
preparation
method
was
developed.
For
purpose,
drug
cocrystallization
as
well
two-step
drying
procedure
were
implemented
order
minimize
crystals
growth
during
solvent
evaporation.
Through
visual
assessment,
mechanical
strength
measurements
scanning
electron
microscopy
imaging,
most
promising
secnidazole-chitosan
cocrystals-loaded
selected
further
physicochemical
(via
differential
calorimetry,
Fourier
transform
infrared
spectroscopy,
X-ray
powder
diffraction,
optical
microscopy)
pharmaceutical
(in
vitro
release,
antimicrobial
swelling
tests)
analyses.
The
impact
utilized
polymeric
composition
polyelectrolyte
complex
structures
form
(crystalline/amorphous)
on
performance
observed.
increased
temperature
enhanced
secnidazole-polymers
miscibility,
desirable
loading
improvement
also
significantly
prolonged
release
artificial
saliva.
