Supramolecular Switching-Enabled Quorum Sensing Trap for Pathogen-Specific Recognition and Eradication to Treat Enteritis DOI
Xiaojie Wu,

Qinggele Borjihan,

Yueying Su

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Intestinal bacterial infections have become a significant threat to human health. However, the current typical antibiotic-based therapies not only contribute drug resistance but also disrupt gut microbiota balance, resulting in additional adverse effects on life activities. There is an urgent need develop new antibacterial materials that selectively eliminate pathogenic bacteria without disrupting beneficial communities or promoting resistance. Herein, we utilize quorum sensing (QS), universal mechanism for regulating community behavior, supramolecular QS trap by encapsulating cucurbit[7]uril (CB[7]) 1-vinyl-3-pentylimidazolium bromide ([VPIM]Br) form switch ([VPIM]Br⊂CB[7]) through host–guest interactions followed grafting it onto cell surfaces using atom transfer radical polymerization. Subsequently, matched pathogens are recognized and aggregated interbacterial signals. Furthermore, addition of amantadine (AD) facilitates release [VPIM]Br competitive binding CB[7] [VPIM]Br⊂CB[7] sterilization. This specifically triggers self-aggregation efficient elimination bacteria. The [VPIM]Br⊂CB[7]-based can increase diversity abundance intestinal microorganisms mice, effectively treating Escherichia coli K88-induced damage perturbing balance. supramolecular-switched opens up promising avenue recognize eradicate antibiotic-free treatment other inflammatory diseases.

Language: Английский

Plasmonic Supramolecular Nanozyme‐Based Bio‐Cockleburs for Synergistic Therapy of Infected Diabetic Wounds DOI Open Access
Xin Wang,

Xudong Qin,

Yi Liu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Abstract Diabetic wounds are a major devastating complication of diabetes due to hyperglycemia, bacterial invasion, and persistent inflammation, the current antibiotic treatments can lead emergence multidrug‐resistant bacteria. Herein, bimetallic nanozyme‐based biomimetic bio‐cocklebur (GNR@CeO 2 @GNPs) is designed synthesized for diabetic wound management by depositing spiky ceria (CeO ) shells gold nanoparticles (GNPs) on nanorod (GNR) nanoantenna. The plasmonic‐enhanced nanozyme catalysis self‐cascade reaction properties simultaneously boost two‐step enzyme‐mimicking catalytic activity GNR@CeO @GNPs, leading significant improvement in overall therapeutic efficacy rather than mere additive effects. Under glucose activation 808 nm laser irradiation, @GNPs material captures photons promotes transfer hot electrons from GNR GNPs into CeO , realizing “butterfly effect” consuming local glucose, overcoming limited antibacterial efficiency an individual PTT modality, providing substantial reactive oxygen species. In vitro vivo experiments demonstrate material's exceptional antibiofilm against Gram‐negative Gram‐positive bacteria, which reduce promote collagen deposition, facilitate angiogenesis, thereby accelerating healing. This study provides promising new strategy develop nanozymes with cascade mode antibiotic‐free synergistic treatment infected wounds.

Language: Английский

Citations

14
3D printing of multifunctional hydrogel scaffolds based on recombinant collagen for bile duct repair DOI Creative Commons
Jianquan Zhang, Yuanhui Gao, Yijun Yang

et al.

APL Materials, Journal Year: 2025, Volume and Issue: 13(2)

Published: Feb. 1, 2025

Bile duct injuries remain a significant clinical challenge following hepatobiliary surgeries. Recently, 3D-printed tubular scaffolds have shown promise as effective solutions for bile tissue repair. This study presents novel bi-layered scaffold, fabricated using advanced three-dimensional printing technology. The inner layer of this scaffold is constructed from poly(ε-caprolactone) methacrylate (PCLMA), which imparts high mechanical strength. outer composed biocompatible methacrylated recombinant type I collagen (rColMA) and ε-poly(L-lysine)-methacrylamide (EPLMA), providing excellent antibacterial properties. In addition, encapsulated interleukin-6-loaded liposomes (IL-6@Lip) are incorporated into the to further promote regeneration. innovative design creates an optimal microenvironment growth differentiation bone marrow mesenchymal stem cells (BMSCs) duct-like cells. These differentiated contribute regeneration, evidenced by expression key markers, including CK7, CK19, AQP1, AE2, CX43. rColMA/EPLMA/IL-6@Lip hydrogel in significantly enhances BMSC proliferation their epithelial Furthermore, vivo experiments show that PCLMA//rColMA/EPLMA/IL-6@Lip does not induce stasis. novel, pre-differentiated active offers valuable insights regeneration replacement research.

Language: Английский

Citations

0
pH triggered polycarvacrol-based antibacterial microspheres: Integrated offensive and defensive platform DOI
Xiangbin Sun, Xiaobing Ma, Yufeng He

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: 228, P. 113811 - 113811

Published: Feb. 7, 2025

Language: Английский

Citations

0
Macrocyclic host molecules: rising as a promising supramolecular material DOI
Xinguo Mao, Shuo Zhang, Qiang Shi

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110950 - 110950

Published: Feb. 1, 2025

Language: Английский

Citations

0
Synthesis of Ceo2@Cao Composite Antibacterial Materials and Their Use for Water Treatment and Mb Dye Degradation DOI

Qianqian Guo,

Xianggeng Wei, Donghui Yang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Enlarged Cleavable Linkages in Shuriken-like Quaternary Ammonium Compounds Providing Safer Bactericides DOI
Xiao‐Qi Xu,

Yanji Chu,

Zhipeng Liu

et al.

Chemistry of Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Although they offer great convenience in preventing microbial infections, the nondegradable feature of most commercial quaternary ammonium compounds (QACs) has led to persistent environmental accumulation, raising significant concerns about their detrimental impacts on public and ecological health. In this study, we report a kind shuriken-like QACs with rapid hydrolysis properties under mild conditions, enabled by introduction enlarged cleavable linkages as backbones. Such present potent bactericidal activity owing multicationic "heads" yet can be converted entirely harmless forms choline silicone oil after degradation. Both cytotoxicity assessment biosafety evaluation confirm nontoxic nature degradation products. The performance fruit preservation infection prevention fabric surfaces further illustrates broad application prospects such degradable within realm food safety With advantages hydrolysis, friendliness, low biotoxicity, concept an "enlarged linkage" strategy will pave way for exploiting generation disinfectants that effectively combat threats while ensuring minimal footprint.

Language: Английский

Citations

0
Nanomedical technologies for bacterial infection prevention and novel perspectives in surgery DOI Open Access
Ilmutdin M. Abdulagatov, Razin Ragimov,

Magomed A. Hamidov

et al.

Journal of Experimental and Clinical Surgery, Journal Year: 2025, Volume and Issue: 18(1), P. 68 - 78

Published: March 14, 2025

This paper provides an overview of the current state-of-the-art for using nanotechnology achievements in medicine Russia and abroad. The perspectives challenges associated with development implementation antibacterial nanocoatings industry creating medical implants, instruments devices are considered. Synthesis technologies deposition on surface implants surgical products materials discussed. results preliminary research field nanomedicine their various applications surgery, as well future perspectives, presented. authors support effectiveness to impart properties order prevent postoperative complications, fact ensuring improved quality, service life reliability implants. Nanocoatings allow providing barrier properties, high strength, wear resistance, corrosion necessary favorable physical properties. As demonstrated, based analysed published Russian foreign papers, application functional allows solving numerous problems medicine: particular, it prevents penetration toxic substances from implant into body, biofilm formation infectious since some nanofilms have properties; increases due anticorrosive activity titanium and, most importantly, improves quality patients. describes fundamental principles atomic layer (ALD) a wide range problems, competitiveness developed national technology compared world analogues.

Language: Английский

Citations

0
Design and synthesis of metal–organic cycles/cages (MOCs) and their applications DOI Creative Commons
Yuanyuan Li, Fengmin Zhang, Yan Sun

et al.

APL Materials, Journal Year: 2024, Volume and Issue: 12(7)

Published: July 1, 2024

Metal–organic cycles/cages (MOCs) are a class of nanoscale molecular entities that possess distinct shapes and sizes designed synthesized through the predictable integration organic inorganic ligands. The diverse functionalities MOCs render them valuable in fields biology, chemistry, materials. First, cavity renders suitable for host–guest interactions, which subsequently employed to induce conformational changes, this approach is particularly advantageous catalysis, sensing, controlled loading release. Furthermore, MOC- polymer-based aggregates can be applied biomedical research cascaded light-harvesting systems. Benefiting from high specific surface area, initial exploration MOC-based hierarchical assemblies indicates their potential applications biomedicine catalysis. microsheets centimeter films used dual-mode catalysis novel wound dressing nonhealing wounds. In addition, design synthesis with different various strategies discussed. We summarized latest progress past 5 years Review.

Language: Английский

Citations

1
Antimicrobial Macrocycles – Synthesis, Characterization, and Activity Comparison with Their Linear Polycationic Analogues DOI
Rafał J. Kopiasz, Maciej Dranka, Waldemar Tomaszewski

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

One of the promising candidates for new antimicrobial agents is membrane-lytic compounds that kill microbes through cell membrane permeabilization, such as peptides (AMPs) and their synthetic mimics (SMAMPs). Although SMAMPs have been under investigation nearly 30 years, a few challenges must be addressed before they can reach clinical use. In this work, step-growth polymerization leading to already-known highly ionenes was redirected toward formation macrocyclic quaternary ammonium salts (MQAs) employing high dilution principle. Antimicrobial assays cytotoxicity studies revealed activity MQAs better selectivity than polymeric analogues. Therefore, seem class antibacterial agents. Additionally, experiments using large unilamellar liposomes (LUVs) whole cells significant differences between in ability adsorb onto surface LUVs well permeate lipid bilayer.

Language: Английский

Citations

1
Novel octacationic-resorcin[4]arenes featuring quaternary ammonium groups as multivalent biocides DOI Creative Commons
Vittoria Ferrara, Veronica Iuliano, Placido Neri

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(15), P. 4101 - 4108

Published: Jan. 1, 2024

We obtained Multi-QACs (quaternary ammonium compounds) by introducing tetraalkylammonium groups on the wider rim of resorcin[4]arenes. These new compounds exhibit significant bacteriostatic activity and a surprising multivalent effect.

Language: Английский

Citations

0