ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(10), P. 5302 - 5311
Published: Oct. 10, 2024
The
development
of
stimulus-responsive
and
amplification-based
strategies
is
crucial
for
achieving
improved
spatial
specificity
enhanced
sensitivity
in
tumor
molecular
imaging,
addressing
challenges
such
as
off-tumor
signal
leakage
limited
biomarker
content.
Therefore,
a
cyclically
activated
enzymatic
biosensor
based
on
the
modification
an
AP
site
within
tetrahedral
framework
DNA
(AP-tFNA)
was
rationally
developed
cell-specific
imaging
using
endogenous
enzyme
apurinic/apyrimidinic
endonuclease
1
(APE1)
target,
exhibiting
superior
high
sensitivity.
APE1,
which
predominantly
localizes
nucleus
normal
cells
but
exhibits
cytosolic
expression
cancer
cells,
can
specifically
recognize
cleave
AP-tFNA,
resulting
separation
fluorophore
quenching
group,
thereby
inducing
fluorescence
signal.
Additionally,
upon
completion
excision
one
APE1
released,
initiating
subsequent
cycle
hydrolytic
cleavage
reactions.
experimental
results
demonstrated
that
AP-tFNA
enables
precise
differentiation
both
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(9), P. 5630 - 5649
Published: Aug. 16, 2024
Fluorine
magnetic
resonance
imaging
(19F
MRI)
is
a
rapidly
evolving
research
area
with
high
potential
to
advance
the
field
of
clinical
diagnostics.
In
this
review,
we
provide
an
overview
recent
progress
in
fluorinated
stimuli-responsive
polymers
applied
as
19F
MRI
tracers.
These
respond
internal
or
external
stimuli
(e.g.,
temperature,
pH,
oxidative
stress,
and
specific
molecules)
by
altering
their
physicochemical
properties,
such
self-assembly,
drug
release,
polymer
degradation.
Incorporating
noninvasive
labels
enables
us
track
biodistribution
polymers.
Furthermore,
triggering
transformation,
can
induce
changes
signals,
including
attenuation,
amplification,
chemical
shift
changes,
monitor
alterations
environment
tracer.
Ultimately,
review
highlights
emerging
fluoropolymer
tracers
current
context
diagnostics
research.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(11), P. 7015 - 7057
Published: Oct. 18, 2024
Biomedical
polymers
play
a
key
role
in
preventing,
diagnosing,
and
treating
diseases,
showcasing
wide
range
of
applications.
Their
unique
advantages,
such
as
rich
source,
good
biocompatibility,
excellent
modifiability,
make
them
ideal
biomaterials
for
drug
delivery,
biomedical
imaging,
tissue
engineering.
However,
conventional
suffer
from
poor
degradation
Nanoscale,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
pH-responsive
aqueous
nanoassembly
from
a
fluorescent
neutral
polyester
selectively
targets
mitochondria
in
cancer
cells
over
non-cancerous
due
to
positive
charge
gain,
while
similar
assemblies
cationic
polyesters
show
no
such
selectivity.
ACS Macro Letters,
Journal Year:
2025,
Volume and Issue:
unknown, P. 558 - 563
Published: April 21, 2025
We
report
a
self-immolative
polymer
(SIP)
that
generates
fluorescent
response
upon
metathesis
depolymerization.
Functionally
distinct
from
other
degradable
polymers,
SIPs
offer
the
ability
to
release
many
subunits
per
one
signal
molecule,
making
them
advantageous
for
variety
of
applications
such
as
molecular
detection
and
amplification.
Utilizing
robust
copper(I)-catalyzed
azide-alkyne
cycloaddition
(CuAAC)
chemistry
orthogonally
functionalize
alkynes,
fluorophore
coumarin
quencher
4-((4-(dimethylamino)phenyl)azo)
(DABCYL)
were
efficiently
installed
side
chains
on
SIP.
The
depolymerization
mediated
by
Grubbs
3rd-generation
(G3)
organoruthenium
initiator
enabled
fluorescence
turn-on
under
nanomolar
SIP
concentrations.
To
demonstrate
utility
fluorogenic
SIP,
we
showed
temperature-dependent
this
metathesis-triggered
using
thermally
responsive
2nd-generation
(G2)
initiator.
Biomacromolecules,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 30, 2025
This
paper
reports
a
modular
design
of
self-immolative
poly(benzyl
ether)
(PBE)
amphiphiles
that
allows
precise
control
over
polymer
chain
structure,
end-group
placement,
and
degradation
behavior.
By
tuning
block
sequences
exposing
reactive
end
groups,
these
undergo
efficient
head-to-tail
depolymerization
upon
external
stimuli.
Structural
variations
in
the
monomers
enable
micelle
formation
with
groups
displayed
on
surface,
while
carboxylate
content
hydrophilic
influences
global
morphology.
The
resulting
micelles
are
degradable
aqueous
environments
can
transform
into
spherical
structures
when
combined
conventional
surfactants.
As
proof
concept,
small-molecule
cargos
were
successfully
loaded
released
from
mixed
demand.
platform
offers
versatile
route
to
create
functional,
stimulus-responsive
surfactants
tunable
assembly,
degradation,
controlled
release
capabilities.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 26, 2025
Abstract
Stimulus-responsive
triplet
excited
states
and
multiexcitonic
logic
gates
have
garnered
increasing
interest.
Singlet
fission
is
an
efficient
multiple
exciton
generation
process,
in
which
one
singlet
converts
into
two
triplets.
is,
however,
rarely
reported
to
be
switchable
by
external
stimuli.
Here
we
design
a
meta
-diethynylphenylene-linked
tetracene
dimer
featuring
pyridyl
endgroups
that
function
as
acid/base-responsive
switch,
enabling
the
reversible
modulation
of
fission.
In
its
neutral
form,
interchromophore
charge-transfer
state
facilitates
promotes
formation
correlated
triplet-pair
state.
Upon
treatment
with
acid,
protonation
nitrogens
generates
more
strongly
electron-accepting
pyridinium,
leading
intra-chromophore
state,
inhibits
Finally,
IMPLICATION
gate
constructed
using
acid
base
inputs
monitoring
based
on
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(45), P. 11826 - 11840
Published: Jan. 1, 2024
Esterase
and
reactive
oxygen
species-responsive
polymer-chlorambucil
conjugates
form
self-assembled
nanoaggregates,
which
surrogate
another
anticancer
drug,
doxorubicin,
show
synergistic
activity
by
receptor-mediated
endocytosis.
