Microenvironment Responsive Biomineralization Nanofirework Employing H2S-Assisted Photothermal Therapy to Prompt Bacterial Wound Healing DOI
Xianan Li, Hairui Deng,

Lingfeng Pan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(17), P. 20678 - 20689

Published: Aug. 17, 2024

Infected wounds present a complex challenge characterized by the dual problems of bacterial overgrowth and delayed healing. Conventional treatments have yet to address these issues concurrently effectively. In response this, we developed nanofirework, ZnS/CuS@BSA (BSA, bovine serum albumin), synthesized via biomineralization process. This nanocomposite is designed for hydrogen sulfide (H2S)-assisted photothermal therapy (PTT) targeting infections in wounds. Upon exposure 808 nm laser irradiation, CuS component nanofirework efficiently converts light energy into heat, which denatures bacteria wound. Simultaneously, acidic environment at wound site catalyzes controlled release H2S from ZnS component. released not only inhibits peroxidase activity, increases levels reactive oxygen species (ROS), but also enhances cell migration proliferation, accelerating healing Furthermore, concurrent zinc ions (Zn2+) compromises membrane integrity, enhancing overall antibacterial efficacy nanocomposite. Both vitro vivo studies substantiated capability significantly promote proliferation inhibit growth, thereby facilitating rapid infected innovative approach, integrating with PTT through biomineralized offers promising antibiotic-free strategy. It has potential enhance treatment wounds, presenting synergistic antimicrobial effect.

Language: Английский

Sprayable Hydrogel for pH-Responsive Nanozyme-Derived Bacteria-Infected Wound Healing DOI

Furong Chao,

Chengliang Cao, Yin Xu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Long-term inflammation and persistent bacterial infection are primary contributors to unhealed chronic wounds. The use of conventional antibiotics often leads bacteria drug resistance, diminishing wound healing effectiveness. Nanozymes have become a promising alternative antimicrobial materials due their low cost, easy synthesis, good stability. Herein, we develop novel sprayable hydrogel based on carboxymethyl chitosan (CMCS) oxidized hyaluronic acid (OHA), incorporating Au nanoparticle-carbon nitride (AuNPs-C3N4) nanozyme, glucose, Mn2+ for bacteria-infected healing. forms rapidly in situ upon spraying gradually degrades the area, releasing AuNPs-C3N4 which exhibits robust glucose oxidase-like (GOx-like) activity, initiating comprehensive catalytic cascade through Mn2+-mediated Fenton-like reaction that generates hydroxyl radicals (•OH) eliminate Staphylococcus aureus (S. aureus) Methicillin-resistant S. (MRSA). Computational results indicate interactions between AuNPs g-C3N4 maximize synergistic effects heterojunction, improving O2 adsorption facilitating electron-O2 optimize activity. Further experiments demonstrate can cover wounds situ, while CMCS promotes collagen production fibroblast proliferation, offering viable strategy

Language: Английский

Citations

1
Polymerization in Living Organisms for Biomedical Applications DOI Open Access

Xin Yun,

Yansong Dong, Zhishen Ge

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Abstract Intra‐tissue polymerization as a kind of reaction in biological tissues has the advantages good biocompatibility, accurate localization, and dynamic response. In this review, progress applications intra‐tissue technologies biomedicine are summarized. The biomedical different discussed, including living neural to improve device performance, preparation electronic devices plants animals, tumor for therapeutic monitoring purposes, skin wound therapy. Various strategies, electrochemical polymerization, enzymatic photopolymerization, free radical used described methods. Moreover, challenges field such precise control reactions development biocompatible materials, future direction is also prospected.

Language: Английский

Citations

0
Metal-Free Nanozyme-Hydrogel Enabled by Conductive Polymer Nanofibers for Multimodal Antibacterial Therapy DOI
Wenya Xu, Ziyi Zhu,

Zhen Tan

et al.

Chemistry of Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Stimuli-responsive hydrogels for skin wound healing and regeneration DOI Creative Commons
Hai Xin, D S Abdullah Al Maruf,

Foluso Akin-Ige

et al.

Emergent Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Abstract Skin wounds are not only an aesthetic concern but also pose great risks to quality of life and general health. As the most promising biomaterial, hydrogels three-dimensional polymeric networks have attracted intense research attention. Hydrogels developed a diverse range biomedical biopharmaceutical applications, owing their large water content, biocompatibility, tunable mechanical properties, stimuli-responsiveness. Stimuli-responsive smart materials which exhibit gelation, structural, degradation, performance function changes when treated with external stimulations. Using these prepare wound dressing is rapidly growing area has exhibited encouraging healing outcomes in small animal models, especially for treatment chronic wounds, diabetic persistent skin inflammations. The present work gives detailed critical analysis on design strategies, gelation mechanisms, selection, stimuli-responsiveness, hydrogel drug release profiles, dressings prepared by sensitivity temperature, pH, reactive oxygen species (ROS), glucose, enzymes, lights. We summarize, analyze, critically evaluate recent publications this explain, compare, assess why how various synthetic bio-polymers utilized scientists develop next generation regeneration. Graphical abstract

Language: Английский

Citations

2
Microenvironment Responsive Biomineralization Nanofirework Employing H2S-Assisted Photothermal Therapy to Prompt Bacterial Wound Healing DOI
Xianan Li, Hairui Deng,

Lingfeng Pan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(17), P. 20678 - 20689

Published: Aug. 17, 2024

Infected wounds present a complex challenge characterized by the dual problems of bacterial overgrowth and delayed healing. Conventional treatments have yet to address these issues concurrently effectively. In response this, we developed nanofirework, ZnS/CuS@BSA (BSA, bovine serum albumin), synthesized via biomineralization process. This nanocomposite is designed for hydrogen sulfide (H2S)-assisted photothermal therapy (PTT) targeting infections in wounds. Upon exposure 808 nm laser irradiation, CuS component nanofirework efficiently converts light energy into heat, which denatures bacteria wound. Simultaneously, acidic environment at wound site catalyzes controlled release H2S from ZnS component. released not only inhibits peroxidase activity, increases levels reactive oxygen species (ROS), but also enhances cell migration proliferation, accelerating healing Furthermore, concurrent zinc ions (Zn2+) compromises membrane integrity, enhancing overall antibacterial efficacy nanocomposite. Both vitro vivo studies substantiated capability significantly promote proliferation inhibit growth, thereby facilitating rapid infected innovative approach, integrating with PTT through biomineralized offers promising antibiotic-free strategy. It has potential enhance treatment wounds, presenting synergistic antimicrobial effect.

Language: Английский

Citations

0