Holistic One Health Surveillance Framework: Synergizing Environmental, Animal, and Human Determinants for Enhanced Infectious Disease Management

ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: 10(3), P. 808 - 826

Published: Feb. 28, 2024

Recent pandemics, including the COVID-19 outbreak, have brought up growing concerns about transmission of zoonotic diseases from animals to humans. This highlights requirement for a novel approach discern and address escalating health threats. The One Health paradigm has been developed as responsive strategy confront forthcoming outbreaks through early warning, highlighting interconnectedness humans, animals, their environment. system employs several innovative methods such use advanced technology, global collaboration, data-driven decision-making come with an extraordinary solution improving worldwide disease responses. Review deliberates environmental, animal, human factors that influence risk, analyzes challenges advantages inherent in using surveillance system, demonstrates how these can be empowered by Big Data Artificial Intelligence. Holistic Surveillance Framework presented herein holds potential revolutionize our capacity monitor, understand, mitigate impact infectious on populations.

Language: Английский

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Advances in design and preparation of nanozymes and their applications for constructing higher sensitive lateral flow assays

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215797 - 215797

Published: April 4, 2024

Language: Английский

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Impact of Metabolites from Foodborne Pathogens on Cancer

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3886 - 3886

Published: Dec. 1, 2024

Foodborne pathogens are microorganisms that cause illness through contamination, presenting significant risks to public health and food safety. This review explores the metabolites produced by these pathogens, including toxins secondary metabolites, their implications for human health, particularly concerning cancer risk. We examine various such as Salmonella sp., Campylobacter Escherichia coli, Listeria monocytogenes, detailing specific of concern carcinogenic mechanisms. study discusses analytical techniques detecting chromatography, spectrometry, immunoassays, along with challenges associated detection. covers effective control strategies, processing techniques, sanitation practices, regulatory measures, emerging technologies in pathogen control. manuscript considers broader highlighting importance robust policies, awareness, education. identifies research gaps innovative approaches, recommending advancements detection methods, preventive policy improvements better manage foodborne metabolites.

Language: Английский

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Research Progress in Small-Molecule Detection Using Aptamer-Based SERS Techniques

Biosensors, Journal Year: 2025, Volume and Issue: 15(1), P. 29 - 29

Published: Jan. 8, 2025

Nucleic acid aptamers are single-stranded oligonucleotides that selected through exponential enrichment (SELEX) technology from synthetic DNA/RNA libraries. These can specifically recognize and bind to target molecules, serving as specific recognition elements. Surface-enhanced Raman scattering (SERS) spectroscopy is an ultra-sensitive, non-destructive analytical technique rapidly acquire the “fingerprint information” of measured molecules. It has been widely applied in qualitative trace analysis across various fields, including food safety, environmental monitoring, biomedical applications. Small such toxins, antibiotics, pesticides, have significant biological effects harmful both human health environment. In this paper, we mainly introduced application research progress SERS detection with (aptamer-based techniques) field small-molecule detection, particularly pesticide (animal) residues, toxins. And prospect combining two methods were reviewed.

Language: Английский

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Advancements and Challenges on SERS-based Multimodal Biosensors for Biotoxin Detection

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 152, P. 104672 - 104672

Published: Aug. 18, 2024

Language: Английский

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Ultrasensitive Electrochemiluminescence Biosensing Platform Based on Polymer Dots with Aggregation-Induced Emission for Dual-Biotoxin Assay

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(29), P. 37748 - 37756

Published: July 11, 2024

Multitarget assay has always been a hot topic in electrochemiluminescence (ECL) methods. Herein, "on-off-on" ECL aptasensor was developed for the ultrasensitive and sequential detection of possible biological warfare agents, deoxynivalenol (DON) abrin (ABR). As luminophore, polymer dots (Pdots) with aggregation-induced emission exhibit high efficiency aptasensor, i.e., signal "on" state. The DON assays mainly depend on quenching due to efficient effect between ferrocene-H2-ferrocene (Fc-H2-Fc) Pdots, "off" When is incubated oligonucleotide sequence S2 replace Fc-H2-Fc, obvious recovery occurs, state, which can be used sequentially detect ABR. limit (LOD) 0.73 fg·mL-1 range 5.0 50 ng·mL-1; LOD ABR ∼0.38 pg·mL-1 1.25 μg·mL-1. as-designed exhibits good stability reproducibility, specificity, favorable practicality. Therefore, this work provides new approach food safety as model design an biosensor multitarget detection.

Language: Английский

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Phytochemical fingerprinting of phytotoxins as a cutting-edge approach for unveiling nature’s secrets in forensic science

Natural Products and Bioprospecting, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

The integration of phytochemistry into forensic science has emerged as a groundbreaking frontier, providing unprecedented insights nature's secrets through the precise application phytochemical fingerprinting phytotoxins cutting-edge approach. This study explores dynamic intersection and science, highlighting how unique profiles toxic plants their secondary metabolites, serve distinctive markers for investigations. By utilizing advanced techniques such Ultra-High-Performance Liquid Chromatography (UHPLC) High-Resolution Mass Spectrometry (HRMS), detection quantification plant-derived are made more accurate in contexts. Real-world case studies presented to demonstrate critical role plant toxins outcomes legal proceedings. challenges, potential, future prospects integrating were discussed. review aims illuminate promising tool enhance precision depth analyses, offering new complex stories embedded toxins.

Language: Английский

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A Novel Colorimetric Sensor Composed from Alkaline Phosphatase-Graphene Oxide Nanoconjugates and Enzyme Induced Gold Nanoparticle Aggregation for the Detection of Deoxynivalenol-3-Glucoside

Published: Jan. 1, 2025

Goji berry is highly susceptible to fungal and mycotoxin during the processing storage. Current detection methods require use of complex sample preparation, expensive analytical platforms professional operators, making rapid on-site difficult. This study explored a sensor based on β-Co(OH)2 nanosheets mediated composite material from graphene oxide (MGO), polyethyleneimine (PEI), alkaline phosphatase (ALP) referred as MGO@PEI-ALP conjugate for masked (Deoxynivalenol-3-glucoside, D3G) in goji berries. The new was able detect D3G range 0.50-3.50 mg/L with 0.30 limit detection, well below maximum standard (1.0 mg) specified by European Union. Meanwhile, this method could effectively remove dietary agricultural products. suggested visualization approach recognition mycotoxin, offering valuable insights food safety quality.

Language: Английский

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Nomograms applicability in clinical toxicology – enhancing precision in clinical decision-making: a systematic review

Critical Reviews in Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: Feb. 13, 2025

Nomograms represent powerful predictive tools that could be easily applied to guide managing acutely intoxicated patients. Thus, several nomograms were developed and validated in the last few decades predict various outcomes following acute poisoning. However, adopted remain sporadic efforts of researchers limited their usefulness clinical settings. We aimed bridge gap between theoretical formulation hands-on application benefit poisoned In this context, systematic review was conducted a reference for implementing these toxicology practice. This included 27 studies published over 60 years. A total 60,883 patients ranging 2 91 years enrolled. These elaborated 38 nomograms; 13 addressed poisoning general, 25 specially designed six poisons/categories, including pesticides (n = 9), psychotropic drugs 5), alcohol 4), analgesics, anti-inflammatory medications 3), carbon monoxide 2), digoxin 2). Despite first nomogram 1960, 81.5% emerged after 2016, with significant increase trend (p < .001). The Glasgow Coma Scale, patient age, poison concentration, bicarbonate level, blood pressure most frequently used predictors. eight outcomes, mortality 14, 36.8%), need intensive care unit (ICU) admission 9, 23.7%), complications 6, 15.8%), optimization therapy 4, 10.5%), severity 2, 5.3%). Also, mechanical ventilation (MV), diagnosis poisoning, suicidal predicted by one each them. nomograms' performances tested using receiver operating characteristic analysis area under curve 26 derived ranged 0.839 0.999. External validation on 16 only; 15 cohorts within same nomograms. only subjected external other studies. externally consist 10 particular and, un-specified poison-specific concerned methanol opioid 1), clozapine 1). Regarding general approach, two mortality. Nevertheless, four separate prediction complications, ICU admission, MV, established ensured performance reliability universal applicability Meanwhile, remaining 22 lacking promising research opportunities.

Language: Английский

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Advances in chromatography: contemporary techniques and applications

Essential Chem, Journal Year: 2025, Volume and Issue: 2(1), P. 1 - 27

Published: March 13, 2025

Language: Английский

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