Multiple Stimuli‐Responsive MXene‐Based Hydrogel as Intelligent Drug Delivery Carriers for Deep Chronic Wound Healing

Small, Journal Year: 2021, Volume and Issue: 18(5)

Published: Nov. 25, 2021

Chronic wound healing is an important and basic issue in medical healthcare fields. Recently, stimuli-responsive hydrogel systems have emerged as promising drug delivery carriers for management. However, given to the limited therapeutic outcomes, new efficient treatment are urgently needed. Here, development of a 2D MXene-based system highly photo- magnetic-responsive oriented deep chronic wounds repair presented. The intelligent responsive composed MXene-wrapped magnetic colloids poly(N-isopropyl acrylamide)-alginate dual-network hydrogels. It demonstrated that exhibits multiple response capability controllable ability, which can reduce toxic side effects drugs promote process well. Notably, practical performance by applying it full-thickness cutaneous subcutaneous infected rat model, indicates great prospect clinical other related biomedical

Language: Английский

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In Situ 3D Bioprinting Living Photosynthetic Scaffolds for Autotrophic Wound Healing

Research, Journal Year: 2022, Volume and Issue: 2022

Published: Jan. 1, 2022

Three-dimensional (3D) bioprinting has been extensively explored for tissue repair and regeneration, while the insufficient nutrient oxygen availability in printed constructs, as well lack of adaptive dimensions shapes, compromises overall therapeutic efficacy limits their further application. Herein, inspired by natural symbiotic relationship between salamanders algae, we present novel living photosynthetic scaffolds using an situ microfluidic-assisted 3D strategy adapting irregular-shaped wounds promoting healing. As oxygenic photosynthesis unicellular microalga (Chlorella pyrenoidosa) was incorporated during printing, generated could produce sustainable under light illumination, which facilitated cell proliferation, migration, differentiation even hypoxic conditions. Thus, when microalgae-laden were directly into diabetic wounds, they significantly accelerate chronic wound closure alleviating local hypoxia, increasing angiogenesis, extracellular matrix (ECM) synthesis. These results indicate that microalgae offers effective autotrophic biosystem healing, suggesting a promising diverse engineering applications.

Language: Английский

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1D, 2D, and 3D scaffolds promoting angiogenesis for enhanced wound healing

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 437, P. 134690 - 134690

Published: Jan. 15, 2022

Language: Английский

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Bioengineering methods for vascularizing organoids

Cell Reports Methods, Journal Year: 2024, Volume and Issue: 4(6), P. 100779 - 100779

Published: May 16, 2024

Organoids, self-organizing three-dimensional (3D) structures derived from stem cells, offer unique advantages for studying organ development, modeling diseases, and screening potential therapeutics. However, their translational ability to mimic complex in vivo functions are often hindered by the lack of an integrated vascular network. To address this critical limitation, bioengineering strategies rapidly advancing enable efficient vascularization organoids. These methods encompass co-culturing organoids with various cell types, lineage-specific organoids, co-differentiating cells into organ-specific lineages, using organoid-on-a-chip technology integrate perfusable vasculature within 3D bioprinting also create This review explores field organoid vascularization, examining biological principles that inform approaches. Additionally, envisions how converging disciplines biology, biomaterials, advanced fabrication technologies will propel creation increasingly sophisticated models, ultimately accelerating biomedical discoveries innovations.

Language: Английский

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Recent advances in 3D bioprinting of vascularized tissues

Materials & Design, Journal Year: 2020, Volume and Issue: 199, P. 109398 - 109398

Published: Dec. 10, 2020

3D bioprinting is a technology that combines computing science, biology and material engineering. It has been extensively explored to fabricate vascularized constructs for tissue This scalable, reproducible highly precise fabrication offers great potential achieve vascularization in printed tissues, which an important milestone towards organ printing the foreseeable future. A successful integrates range of hierarchical, perfusable channels within mechanically supportive biomaterials. review summarises recent advances tissues. Firstly, common biomaterials used as bioinks are introduced. While natural polymers more suitable mimic extracellular matrix resulting effective cell growth, synthetic offer tailorable mechanical properties printability. Afterwards, main techniques their most practical applications fabricating vascular networks described. Furthermore, future trends prospects also discussed.

Language: Английский

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3D printing technology as innovative solutions for biomedical applications

Drug Discovery Today, Journal Year: 2020, Volume and Issue: 26(2), P. 360 - 383

Published: Nov. 16, 2020

Language: Английский

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Prevascularized Micro-/Nano-Sized Spheroid/Bead Aggregates for Vascular Tissue Engineering

Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 13(1)

Published: Aug. 18, 2021

Efficient strategies to promote microvascularization in vascular tissue engineering, a central priority regenerative medicine, are still scarce; nano- and micro-sized aggregates spheres or beads harboring primitive microvascular beds promising methods engineering. Capillaries the smallest type numerous blood vessels, which distributed densely cardiovascular system. To mimic this network, specific cell components proangiogenic factors required. Herein, advanced biofabrication including extrusion-based droplet-based bioprinting, Kenzan, biogripper approaches, deliberated with emphasis on newest works prevascular microspheres/microbeads.

Language: Английский

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Digital light processing (DLP)‐based (bio)printing strategies for tissue modeling and regeneration

Aggregate, Journal Year: 2022, Volume and Issue: 4(2)

Published: Oct. 3, 2022

Abstract Digital light processing (DLP)‐based bioprinting technology has recently aroused considerable concerns as a strategy to deliver biomedical materials and/or specific cells create sophisticated structures for various tissue modeling and regeneration. In this review, we display concise introduction of DLP bioprinting, further discussion on the design manufacture (bio)printer with varied bioinks their applications toward drug screening, disease modeling, repair, regenerative medicine. Finally, advantages, challenges, perspectives printing platforms are detailed. It is believed that will play decisive role in field model medicine, mainly due its time‐efficient, higher resolution, amenability automation needs.

Language: Английский

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Production of Multiple Cell‐Laden Microtissue Spheroids with a Biomimetic Hepatic‐Lobule‐Like Structure

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(36)

Published: July 19, 2021

The construction of an in vitro 3D cellular model to mimic the human liver is highly desired for drug discovery and clinical applications, such as patient-specific treatment cell-based therapy regenerative medicine. However, current bioprinting strategies are limited their ability generate multiple cell-laden microtissues with biomimetic structures. This study presents a method producing hepatic-lobule-like microtissue spheroids using system incorporating precursor cartridge microfluidic emulsification system. can be successfully generated at speed approximately 45 min

Language: Английский

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Stem Cell-Laden Hydrogel-Based 3D Bioprinting for Bone and Cartilage Tissue Engineering

Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10

Published: May 17, 2022

Tremendous advances in tissue engineering and regenerative medicine have revealed the potential of fabricating biomaterials to solve dilemma bone articular defects by promoting osteochondral cartilage regeneration. Three-dimensional (3D) bioprinting is an innovative fabrication technology precisely distribute cell-laden bioink for construction artificial tissues, demonstrating great prospect joint areas. With well controllable printability, biocompatibility, biodegradability, mechanical properties, hydrogels been emerging as attractive 3D material, which provides a favorable biomimetic microenvironment cell adhesion, orientation, migration, proliferation, differentiation. Stem cell-based therapy has known promising approach medicine; however, limitations arise from uncontrollable differentiation stem cells fortunately could be improved after were encapsulated hydrogel. In this review, our focus was centered on characterization application hydrogel-based engineering. We not only highlighted effect various kinds hydrogels, cells, inorganic particles, growth factors chondrogenesis osteogenesis but also outlined relationship between biophysical properties like osteoinductivity, regeneration cartilage. This study invented discuss challenge we encountering, recent progress achieved, future perspective proposed field.

Language: Английский

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