Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
60(44), P. 23695 - 23704
Published: Aug. 30, 2021
We
report
the
first
cellular
application
of
emerging
near-quantitative
photoswitch
pyrrole
hemithioindigo,
by
rationally
designing
photopharmaceutical
PHTub
inhibitors
cytoskeletal
protein
tubulin.
PHTubs
allow
simultaneous
visible-light
imaging
and
photoswitching
in
live
cells,
delivering
cell-precise
photomodulation
microtubule
dynamics,
photocontrol
over
cell
cycle
progression
death.
This
is
acute
use
a
hemithioindigo
for
high-spatiotemporal-resolution
biological
control
cells.
It
additionally
demonstrates
utility
photoswitches,
enabling
dark-active
design
to
overcome
residual
background
activity
during
photopatterning.
work
opens
up
new
horizons
high-precision
research
using
shows
applicability
as
valuable
scaffold
range
other
targets.
Bioactive Materials,
Journal Year:
2021,
Volume and Issue:
9, P. 428 - 445
Published: Aug. 5, 2021
Periodontitis
is
an
inflammatory
disease
initiated
by
bacterial
infection,
developed
excessive
immune
response,
and
aggravated
high
level
of
reactive
oxygen
species
(ROS).
Hence,
herein,
a
versatile
metal-organic
framework
(MOF)-based
nanoplatform
prepared
using
mesoporous
Prussian
blue
(MPB)
nanoparticles
to
load
BA,
denoted
as
MPB-BA.
The
established
MPB-BA
serves
shelter
reservoir
for
vulnerable
immunomodulatory
drug
which
possesses
antioxidant,
anti-inflammatory
anti-bacterial
effects.
Thus,
can
exert
its
functions
through
scavenging
intracellular
ROS
switch
macrophages
from
M1
M2
phenotype
so
relieve
inflammation.
underlying
molecular
mechanism
lies
in
the
upregulation
phosphorylated
nuclear
factor
erythroid
2-related
2
(Nrf2)
scavenge
subsequently
inhibit
kappa-B
(NF-κB)
signal
pathway.
Moreover,
also
exhibited
efficient
photothermal
antibacterial
activity
against
periodontal
pathogens
under
near-infrared
(NIR)
light
irradiation.
In
vivo
RNA
sequencing
results
revealed
involvement
both
antioxidant
pathways
after
application.
Meanwhile,
micro-CT
immunohistochemical
staining
p-Nrf2
p-P65
further
confirmed
superior
therapeutic
effects
than
minocycline
hydrochloride.
This
work
may
provide
insight
into
treatment
periodontitis
regulating
Nrf2/NF-κB
signaling
pathway
bioplatform-assisted
immunotherapy.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(50)
Published: Sept. 12, 2021
Abstract
Photoresponsive
biomaterials
are
experiencing
a
transition
from
in
vitro
models
to
vivo
demonstrations
that
point
toward
clinical
translation.
Dynamic
hydrogels
for
cell
encapsulation,
light‐responsive
carriers
controlled
drug
delivery,
and
nanomaterials
containing
photosensitizers
photodynamic
therapy
relevant
examples.
Nonetheless,
the
step
clinic
largely
depends
on
their
combination
with
technologies
bring
light
into
body.
This
review
highlights
challenge
of
photoactivation
vivo,
presents
strategies
management
can
be
adopted
this
purpose.
The
authors’
focus
is
materials‐driven,
particularly
upconversion
nanoparticles
assist
“direct
path”
delivery
through
tissue,
optical
waveguides
“clear
between
external
source
target.
intention
photoresponsive
community
medical
by
presenting
concepts
integrated
targets.
authors
also
aim
stimulate
further
innovation
materials‐based
platforms
highlighting
needs
opportunities
biomaterials.
Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
60(44), P. 23695 - 23704
Published: Aug. 30, 2021
We
report
the
first
cellular
application
of
emerging
near-quantitative
photoswitch
pyrrole
hemithioindigo,
by
rationally
designing
photopharmaceutical
PHTub
inhibitors
cytoskeletal
protein
tubulin.
PHTubs
allow
simultaneous
visible-light
imaging
and
photoswitching
in
live
cells,
delivering
cell-precise
photomodulation
microtubule
dynamics,
photocontrol
over
cell
cycle
progression
death.
This
is
acute
use
a
hemithioindigo
for
high-spatiotemporal-resolution
biological
control
cells.
It
additionally
demonstrates
utility
photoswitches,
enabling
dark-active
design
to
overcome
residual
background
activity
during
photopatterning.
work
opens
up
new
horizons
high-precision
research
using
shows
applicability
as
valuable
scaffold
range
other
targets.
