Medicinal Research Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 3, 2025
ABSTRACT
Adrenoceptors
(ARs)
play
a
vital
role
in
various
physiological
processes
and
are
key
therapeutic
targets.
The
advent
of
optical
control
techniques,
including
optogenetics
photopharmacology,
offers
the
potential
to
modulate
AR
signaling
with
precise
temporal
spatial
resolution.
In
this
review,
we
summarize
latest
advancements
signaling,
encompassing
optogenetics,
photocaged
compounds,
photoswitchable
compounds.
We
also
discuss
limitations
current
tools
provide
an
outlook
on
next
generation
optogenetic
photopharmacological
tools.
These
emerging
technologies
not
only
enhance
our
understanding
but
pave
way
for
developments.
Materials Horizons,
Journal Year:
2023,
Volume and Issue:
10(9), P. 3325 - 3350
Published: Jan. 1, 2023
This
review
provides
a
brief
overview
of
the
recent
developments
in
hydrogel
systems
that
respond
dynamically
to
various
stimuli,
including
some
interesting
fabrication
strategies,
and
their
application
cardiac,
bone,
neural
tissue
regeneration.
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
15(1), P. 138 - 157
Published: April 8, 2022
Neurotransmitters,
as
important
chemical
small
molecules,
perform
the
function
of
neural
signal
transmission
from
cell
to
cell.
Excess
concentrations
neurotransmitters
are
often
closely
associated
with
brain
diseases,
such
Alzheimer's
disease,
depression,
schizophrenia,
and
Parkinson's
disease.
On
other
hand,
release
under
induced
stimulation
indicates
occurrence
reward-related
behaviors,
including
food
drug
addiction.
Therefore,
understand
physiological
pathological
functions
neurotransmitters,
especially
in
complex
environments
living
brain,
it
is
urgent
develop
effective
tools
monitor
their
dynamics
high
sensitivity
specificity.
Over
past
30
years,
significant
advances
electrochemical
sensors
optical
probes
have
brought
new
possibilities
for
studying
neurons
circuits
by
monitoring
changes
neurotransmitters.
This
Review
focuses
on
progress
construction
vivo
analysis
summarizes
current
attempts
address
key
issues
development
selectivity,
sensitivity,
stability.
Combined
latest
technologies
methods,
several
strategies
sensor
provided
recording
environment
brain.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(9), P. 3712 - 3712
Published: April 25, 2023
Photoresponsive
biomaterials
have
garnered
increasing
attention
recently
due
to
their
ability
dynamically
regulate
biological
interactions
and
cellular
behaviors
in
response
light.
This
review
provides
an
overview
of
recent
advances
the
design,
synthesis,
applications
photoresponsive
biomaterials,
including
photochromic
molecules,
photocleavable
linkers,
photoreactive
polymers.
We
highlight
various
approaches
used
control
behavior
these
materials,
modulation
light
intensity,
wavelength,
duration.
Additionally,
we
discuss
fields,
drug
delivery,
tissue
engineering,
biosensing,
optical
storage.
A
selection
significant
cutting-edge
articles
collected
years
has
been
discussed
based
on
structural
pattern
light-responsive
performance,
focusing
mainly
photoactivity
azobenzene,
hydrazone,
diarylethenes,
spiropyrans,
design
smart
materials
as
most
targeted
desirable
application.
Overall,
this
highlights
potential
enable
spatiotemporal
processes
opens
up
exciting
opportunities
for
developing
advanced
with
enhanced
functionality.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(16)
Published: Feb. 8, 2023
Abstract
Extracellular
matrix
(ECM)
proteins
containing
cell‐attachable
Arg‐Gly‐Asp
(RGD)
sequences
exhibit
variable
bridging
and
non‐bridging
in
fibronectin‐collagen
laminin‐collagen
complexes
that
can
regulate
inflammation,
tissue
repair,
wound
healing.
In
this
study,
linking
molecule‐mediated
conjugation
of
1D
magnetic
nanocylinders
(MNCs)
to
material
surfaces
pre‐decorated
with
gold
nanospheres
(GNSs)
is
performed,
thereby
yielding
RGD‐coated
MNCs
(RGD‐MNCs)
over
GNSs
(RGD‐GNSs)
a
state.
The
RGD‐MNCs
are
drawn
closer
the
RGD‐GNSs
via
field‐mediated
compression
molecules
establish
between
them.
Relative
proportion
optimized
yield
effective
remote
stimulation
integrin
binding
variably
bridged
RGDs
similar
invariably
used
as
control
group.
Remote
manipulation
RGD
facilitates
attachment
structure
assembly
macrophages
leads
pro‐healing/anti‐inflammatory
phenotype
acquisition.
contrast,
non‐bridged
inhibited
macrophage
acquired
pro‐inflammatory
phenotypes.
use
various
nanomaterials
constructing
heterogeneous
materials
further
offer
modes
switching
understand
dynamic
integrin‐mediated
modulation
immunomodulatory
responses,
such
foreign
body
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 4, 2025
Abstract
Recent
advances
in
developing
photonic
technologies
using
various
materials
offer
enhanced
biosensing,
therapeutic
intervention,
and
non‐invasive
imaging
healthcare.
Here,
this
article
summarizes
significant
technological
advancements
materials,
devices,
bio‐interfaced
systems,
which
demonstrate
successful
applications
for
impacting
human
healthcare
via
improved
therapies,
advanced
diagnostics,
on‐skin
health
monitoring.
The
details
of
required
necessary
properties,
device
configurations
are
described
next‐generation
followed
by
an
explanation
the
working
principles
light‐based
therapeutics
diagnostics.
Next,
paper
shares
recent
examples
integrated
systems
focusing
on
translation
immediate
clinical
studies.
In
addition,
limitations
existing
devices
future
directions
smart
discussed.
Collectively,
review
focus
trends
new
nanomaterials,
light
delivery
methods,
system
designs,
mechanical
structures,
material
functionalization,
to
advance
digital
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(8)
Published: Jan. 18, 2023
Abstract
In
natural
microenvironment,
various
proteins
containing
adhesive
ligands
in
fibrous
and
non‐fibrous
structures
dynamically
couple
decouple
to
regulate
stem
cell
fate.
Herein,
materials
presenting
movably
couplable
are
developed
by
grafting
liganded
gold
nanoparticles
(AuNPs)
a
substrate
followed
flexibly
movable
linear
nanomaterials
(MLNs)
the
via
long
bendable
linker,
thereby
creating
space
between
MLNs
AuNPs
decoupled
state.
Magnetic
control
of
decreases
this
bending
linker
AuNPs.
Remote
ligand
coupling
stimulates
integrin
recruitment
coupled
ligands,
non‐toxically
facilitating
focal
adhesion,
mechanosensing,
potential
differentiation
cells,
which
is
suppressed
decoupling.
Versatile
tuning
size,
aspect
ratio,
distributions,
can
help
decipher
dynamic
ligand‐coupling‐dependent
fate
advance
regenerative
therapies.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
37, P. 407 - 423
Published: April 23, 2024
Traditional
optical
waveguides
or
mediums
are
often
silica-based
materials,
but
their
applications
in
biomedicine
and
healthcare
limited
due
to
the
poor
biocompatibility
unsuitable
mechanical
properties.
In
term
of
human
body,
a
biocompatible
hydrogel
system
with
excellent
transparency
flexibility
could
be
beneficial.
this
review,
we
explore
different
designs
hydrogel-based
derived
from
natural
synthetic
sources.
We
highlighted
key
developments
such
as
light
emitting
contact
lenses,
implantable
fibres,
biosensing
systems,
luminating
fluorescent
materials.
Finally,
expand
further
on
challenges
perspectives
for
achieve
clinical
applications.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(19)
Published: April 13, 2024
The
emerging
field
of
photopharmacology
is
a
promising
chemobiological
methodology
for
optical
control
drug
activities
that
could
ultimately
solve
the
off-target
toxicity
outside
disease
location
many
drugs
treatment
given
pathology.
use
photolytic
reactions
looks
very
attractive
light-activated
release
but
requires
to
develop
sensitive
red
or
near-infrared
light
excitation
better
tissue
penetration.
This
review
will
present
concepts
triplet-triplet
annihilation
upconversion-based
photolysis
and
their
recent
in
vivo
applications
light-induced
delivery
using
photoactivatable
nanoparticles.
Coordination Chemistry Reviews,
Journal Year:
2024,
Volume and Issue:
515, P. 215921 - 215921
Published: May 21, 2024
Nitric
oxide
(NO)
is
an
important
biochemical
molecule
that
endogenously
produced
to
act
for
instance
as
neurotransmitter,
effect
cell
growth,
or
regulate
the
immune
response.
Therapeutic
treatment
with
exogeneous
NO
difficult
owing
its
gaseous
and
reactive
nature
and,
not
surprising,
specific
molecules
deliver
have
been
developed.
Amongst
various
triggers
deliberately
release
from
these
NO-releasing
molecules,
light
most
elegant
allows
a
high
degree
of
control
over
time
location
NO-release.
For
therapeutic
applications,
it
necessary
use
long-wavelength
light,
preferably
in
red
near
infrared
region,
which
challenging
achieve.
This
review
gives
overview
on
approaches
red-shift
activation
wavelength
light-activated
NO-release
nitrosoamines,
o-substituted
nitroarenes,
L-arginine,
cupferron,
nitrosyl
metal
complexes.
While
focusing
single
photon
excitation
events,
direct
mechanisms
are
covered
well
photoelectron
transfer,
energy
chemiluminescence
photothermal
light-triggered
oxidation
pathways.
each
NO-releaser
class,
photochemical
mechanism
discussed,
biological
applications
mentioned.
SusMat,
Journal Year:
2024,
Volume and Issue:
4(3)
Published: May 27, 2024
Abstract
Spider
silk,
possessing
exceptional
combination
properties,
is
classified
as
a
bio‐gel
fiber.
Thereby,
it
serves
valuable
origin
of
inspiration
for
the
advancement
various
artificial
gel
fiber
materials
with
distinct
functionalities.
Gel
fibers
exhibit
promising
potential
utilization
in
diverse
fields,
including
smart
textiles,
muscle,
tissue
engineering,
and
strain
sensing.
However,
there
are
still
numerous
challenges
improving
performance
functionalizing
applications
spider
silk‐inspired
fibers.
Thus,
to
gain
penetrating
insight
into
bioinspired
fibers,
this
review
provided
comprehensive
overview
encompassing
three
key
aspects:
fundamental
design
concepts
implementing
strategies
properties
strengthening
functionalities
application
prospects
In
particular,
multiple
toughening
mechanisms
were
introduced
at
micro,
nano,
molecular‐level
structures
Additionally,
existing
summarized.
This
aims
offer
significant
guidance
development
inspire
further
research
field
high‐performance
