Organic photosensitizers for antimicrobial phototherapy

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(9), P. 3324 - 3340

Published: Jan. 1, 2022

This tutorial review highlights the concept and significance of antibacterial phototherapy. Recent developments, advantages, challenges organic photosensitizers in this area are also discussed.

Language: Английский

---

The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(6), P. 1983 - 2030

Published: Jan. 1, 2022

This review summarized the progression of AIEgen-based photo-driven theranostics emphasizing on design strategies for efficient photosensitization, photothermal conversion and multimodal functionalities by adjusting excited energy dissipation.

Language: Английский

---

Supramolecular Photosensitizer Enables Oxygen-Independent Generation of Hydroxyl Radicals for Photodynamic Therapy

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(7), P. 4081 - 4087

Published: Feb. 13, 2023

The highly oxygen-dependent nature of photodynamic therapy (PDT) limits its therapeutic efficacy against hypoxic solid tumors in clinics, which is an urgent problem to be solved. Herein, we develop oxygen-independent supramolecular agent that produces hydroxyl radical (•OH) by oxidizing water the presence intracellularly abundant pyruvic acid under oxygen-free conditions. A fluorene-substituted BODIPY was designed as electron donor and coassembled with perylene diimide acceptor form quadruple hydrogen-bonded agent. Detailed mechanism studies reveal intermolecular transfer charge separation upon light irradiation result efficient generation ion pairs. Under conditions, cationic radicals directly oxidize generate cytotoxic •OH, anionic electrons acid, realizing catalytic cycle. Thus, this exhibited superb photocytotoxicity even severe environments excellent vivo antitumor on HeLa-bearing mouse models. This work provides a strategy for constructing agents, opens up avenue effective PDT tumors.

Language: Английский

---

Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405

Published: July 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Language: Английский

---

Triarylboron‐Doped Acenethiophenes as Organic Sonosensitizers for Highly Efficient Sonodynamic Therapy with Low Phototoxicity

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(49)

Published: Oct. 4, 2022

The development of efficient organic sonosensitizers is crucial for sonodynamic therapy (SDT) in the field cancer treatment. Herein, a new strategy based on triarylboron-doped acenethiophene scaffolds presented. attachment boron to linear acenethiophenes lowers lowest unoccupied molecular orbital (LUMO) energy, resulting redshifted absorptions and emissions. After encapsulation with amphiphilic polymer DSPE-mPEG2000 , it found that nanostructured BAnTh-NPs BTeTh-NPs (nanoparticles BAnTh BTeTh) shows hydroxyl radical (• OH) generation under ultrasound (US) irradiation aqueous solution almost no phototoxicity, which can overcome shortcomings O2 -dependent SDT avoid potential cutaneous phototoxicity issue. In vitro vivo therapeutic results validate boron-doped as enable high efficiency low good biocompatibility, indicating boron-functionalization acenes promising toward SDT.

Language: Английский

---

BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self‐Assembly, Properties, and Applications

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(18)

Published: Nov. 18, 2022

Abstract The use of boron dipyrromethene (BODIPY) in biomedicine is reviewed. To open, its synthesis and regulatory strategies are summarized, inspiring cutting‐edge work post‐functionalization highlighted. A brief overview assembly model BODIPY then provided: introduced as a promising building block for the formation single‐ multicomponent self‐assembled systems, including nanostructures suitable aqueous environments, thereby showing great development potential supramolecular applications. frontier progress biomedical application thereafter described, supported by examples frontiers applications BODIPY‐containing smart materials: it mainly involves materials based on blocks their assemblies fluorescence bioimaging, photoacoustic imaging, disease treatment photodynamic therapy, photothermal immunotherapy. Lastly, not only current status family field but also challenges worth considering summarized. At same time, insights into future prospects biomedically applicable provided.

Language: Английский

---

Integration of TADF Photosensitizer as “Electron Pump” and BSA as “Electron Reservoir” for Boosting Type I Photodynamic Therapy

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(14), P. 8130 - 8140

Published: March 31, 2023

Type I photosensitization provides an effective solution to the problem of unsatisfactory photodynamic therapeutic (PDT) effects caused by tumor hypoxia. The challenge in development mode is boost photosensitizer's own electron transfer capacity. Herein, we found that use bovine serum albumin (BSA) encapsulate a thermally activated delayed fluorescence (TADF) photosensitizer PS can significantly promote PDT process generate mass superoxide anions (O2•–). This opened new strategy employing BSA as "electron reservoir" and TADF pump". We integrated these roles one system preparing nanophotosensitizer PS@BSA. performance was demonstrated with cells under hypoxic conditions. Furthermore, PS@BSA took full advantage tumor-targeting role achieved efficient for tumor-bearing mice vivo experiments. work route improve efficiency tumors.

Language: Английский

---

The Current Status of Photodynamic Therapy in Cancer Treatment

Cancers, Journal Year: 2023, Volume and Issue: 15(3), P. 585 - 585

Published: Jan. 18, 2023

Although we have made great strides in treating deadly diseases over the years, cancer therapy still remains a daunting challenge. Among numerous anticancer methods, photodynamic (PDT), non-invasive therapeutic approach, has attracted much attention. PDT exhibits outstanding performance therapy, but some unavoidable disadvantages, including limited light penetration depth, poor tumor selectivity, as well oxygen dependence, largely limit its efficiency for solid tumors treatment. Thus, strategies gone into overcoming these obstacles, such exploring new photosensitizers with higher conversion efficiency, alleviating hypoxia to fuel generation of reactive species (ROS), designing tumor-targeted PS, and applying PDT-based combination strategies. In this review, briefly summarized related approaches, which are mainly characterized by advanced PSs, PSs excellent additional refreshing features. We also summarize therapies effects.

Language: Английский

---

A Dual‐Locked Activatable Phototheranostic Probe for Biomarker‐Regulated Photodynamic and Photothermal Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(26)

Published: April 9, 2022

Activatable phototheranostics holds promise for precision cancer treatment owing to the "turn-on" signals and therapeutic effects. However, most activatable phototheranostic probes only possess photodynamic therapy (PDT) or photothermal (PTT), which suffer from poor efficacy due deficient cellular oxygen complex tumor microenvironment. We herein report a dual-locked probe that activates near-infrared fluorescence (NIRF) in tumor, triggers PDT response tumor-periphery biomarker, switches PTT upon detecting tumor-core-hypoxia biomarker. This PDT-PTT auto-regulated exhibits complete ablation under photoirradiation of single laser source by producing cytotoxic singlet at periphery generating hyperthermia tumor-core where is too hypoxic PDT. represents promising molecular design approach toward precise phototheranostics.

Language: Английский

---

Self-Assembled Metallacage with Second Near-Infrared Aggregation-Induced Emission for Enhanced Multimodal Theranostics

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(28), P. 12825 - 12833

Published: July 5, 2022

The construction of supramolecular coordination complexes (SCCs) featuring prominent cancer theranostic functions is an appealing yet significantly challenging task. In this study, we rationally designed and facilely constructed a prism-like metallacage C-DTTP with efficient fluorescence emission in the second near-infrared (NIR-II) region through assembly aggregation-induced emission-active four-arm ligand 90° Pt acceptors Pt(PEt3)2(OTf)2. held longest maximum wavelength (1005 nm) compared those previously reported SCCs up to now exhibited both high photothermal conversion efficiency (39.3%) superior reactive oxygen species generation behavior precursor ligand. vitro vivo assessments demonstrated that metallacage-loaded nanoparticles excellent biocompatibility stability were capable simultaneously affording precise tumor diagnosis complete elimination by means NIR-II fluorescence/photothermal dual imaging-guided photodynamic/photothermal synergistic therapy.

Language: Английский

---