Organic microelectrode arrays for bioelectronic applications DOI Creative Commons
Zixuan Lu,

Aimie Pavia,

Achilleas Savva

et al.

Materials Science and Engineering R Reports, Journal Year: 2023, Volume and Issue: 153, P. 100726 - 100726

Published: March 16, 2023

Microelectrode arrays (MEAs) are devices that gather multiple microscopic electrodes in a small area and used to electrically record and/or stimulate the biological activity of cells. Recently, MEAs use organic mixed ionic electronic conductors (OMIECs) as active materials, have gained significant attention due profound advantages over traditional metal-based MEAs. OMIECs, usually polymer-based, can be processed from solution offer high-charge capacitance mechanical properties match those These microelectrode with high signal-to-noise ratio low electrochemical impedance. Organic (OMEAs) been applied for vivo applications, showing outstanding biocompatibility lowering "foreign body responses". They also study vitro systems various scales, such tissues (macroscopic), cells (microscopic), membranes (nanoscale thickness), biomolecules (nanoscopic). Here we present an overview OMEA technology. First, discuss OMIECs benefits MEA Then, introduce OMEAs device physics based on typical techniques exemplar OMEAs. We then microfabrication methods functional Finally, collect together recent breakthroughs design novel bioelectronic applications OMEAs, spanning long-term implants electroactive recordings drug discovery, among others. The possibility using light-sensitive optically transparent is discussed this section. Overall, put all aspects necessary further advancement technology, i.e. fundamental materials principles, fabrication foster advances technologies.

Language: Английский

Polymer Semiconductors: Synthesis, Processing, and Applications DOI
Li Ding, Zi‐Di Yu, Xiaoye Wang

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(12), P. 7421 - 7497

Published: May 26, 2023

Polymer semiconductors composed of a carbon-based π conjugated backbone have been studied for several decades as active layers multifarious organic electronic devices. They combine the advantages electrical conductivity metals and mechanical behavior plastics, which are going to become one futures modulable materials. The performance materials depends both on their chemical structures multilevel microstructures in solid states. Despite great efforts that made, they still far from producing clear picture among intrinsic molecular structures, microstructures, device performances. This review summarizes development polymer recent aspects material design related synthetic strategies, processing technologies, functional applications. especially emphasized, plays decisive role determining performance. discussion shows panorama research sets up bridge across finally devices Finally, this discusses grand challenges future opportunities semiconductors.

Language: Английский

Citations

226
Cyano‐Functionalized n‐Type Polymer with High Electron Mobility for High‐Performance Organic Electrochemical Transistors DOI
Kui Feng,

Wentao Shan,

Junwei Wang

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(24)

Published: April 16, 2022

n-Type organic mixed ionic-electronic conductors (OMIECs) with high electron mobility are scarce and highly challenging to develop. As a result, the figure-of-merit (µC*) of n-type electrochemical transistors (OECTs) lags far behind p-type analogs, restraining development OECT-based low-power complementary circuits biosensors. Here, two donor-acceptor (D-A) polymers based on fused bithiophene imide dimer f-BTI2 as acceptor unit thienylene-vinylene-thienylene (TVT) donor co-unit reported. The cyanation TVT enables polymer f-BTI2g-TVTCN simultaneously enhanced ion-uptake ability, film structural order, charge-transport property. it is able obtain volumetric capacitance (C*) 170 ± 22 F cm-3 record OECT (μe,OECT ) 0.24 cm2 V-1 s-1 for f-BTI2g-TVTCN, subsequently achieving state-of-the-art µC* 41.3 cm-1 geometry-normalized transconductance (gm,norm 12.8 S in accumulation-mode OECTs. In contrast, only moderate 1.50 measured non-cyanated f-BTI2g-TVT. These remarkable results demonstrate great power cyano functionalization semiconductors developing OMIECs substantial aqueous environment high-performance

Language: Английский

Citations

103
Bioadhesive Technology Platforms DOI
Sarah J. Wu,

Xuanhe Zhao

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(24), P. 14084 - 14118

Published: Nov. 16, 2023

Bioadhesives have emerged as transformative and versatile tools in healthcare, offering the ability to attach tissues with ease minimal damage. These materials present numerous opportunities for tissue repair biomedical device integration, creating a broad landscape of applications that captivated clinical scientific interest alike. However, fully unlocking their potential requires multifaceted design strategies involving optimal adhesion, suitable biological interactions, efficient signal communication. In this Review, we delve into these pivotal aspects bioadhesive design, highlight latest advances applications, identify lie ahead bioadhesives multifunctional technology platforms.

Language: Английский

Citations

69
H2O2-activated in situ polymerization of aniline derivative in hydrogel for real-time monitoring and inhibition of wound bacterial infection DOI

Aihui Wang,

Guishi Fan,

Hongli Qi

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 289, P. 121798 - 121798

Published: Sept. 8, 2022

Language: Английский

Citations

49
AC amplification gain in organic electrochemical transistors for impedance-based single cell sensors DOI Creative Commons
Filippo Bonafè, Francesco Decataldo, Isabella Zironi

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 15, 2022

Abstract Research on electrolyte-gated and organic electrochemical transistor (OECT) architectures is motivated by the prospect of a highly biocompatible interface capable amplifying bioelectronic signals at site detection. Despite many demonstrations in these directions, quantitative model for OECTs as impedance biosensors still lacking. We overcome this issue introducing experiment where we simulate detection single cell sensing dielectric microparticle. The reproducible allows us to study impact geometry operation conditions device sensitivity. With data rationalize mathematical that provides clear guidelines optimization sensors, verify predictions an in-vitro experiment. In optimized geometry, OECT-based sensor record adhesion detachment transients, showing maximum gain 20.2±0.9 dB with respect electrode-based sensor.

Language: Английский

Citations

42
A retrainable neuromorphic biosensor for on-chip learning and classification DOI
Eveline R. W. van Doremaele, Xudong Ji, Jonathan Rivnay

et al.

Nature Electronics, Journal Year: 2023, Volume and Issue: 6(10), P. 765 - 770

Published: Sept. 14, 2023

Language: Английский

Citations

34
Brain‐Inspired Organic Electronics: Merging Neuromorphic Computing and Bioelectronics Using Conductive Polymers DOI Creative Commons
Imke Krauhausen, Charles‐Théophile Coen, Simone Spolaor

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(15)

Published: Oct. 22, 2023

Abstract Neuromorphic computing offers the opportunity to curtail huge energy demands of modern artificial intelligence (AI) applications by implementing computations into new, brain‐inspired architectures. However, lack fabrication processes able integrate several units monolithic systems and need for hardware‐tailored training algorithms still limit scope application performance neuromorphic hardware. Recent advancements in field organic transistors present new opportunities smart sensing applications, thanks their unique properties such as behavior, low‐voltage operation, mixed ionic‐electronic conductivity. Organic push boundaries efficient hardware AI, facilitating decentralized on‐chip learning serving a foundation advancement closed‐loop intelligent next generation. The biocompatibility dual conductivity materials introduce prospects biointegration bioelectronics. Their ability sense regulate biosystems, well neuro‐inspired functions can be combined with create next‐generation These will seamlessly interact biological locally compute biosignals relevant matter.

Language: Английский

Citations

32
Nanomaterial-based microelectrode arrays for in vitro bidirectional brain–computer interfaces: a review DOI Creative Commons
Yaoyao Liu, Shihong Xu, Yan Yang

et al.

Microsystems & Nanoengineering, Journal Year: 2023, Volume and Issue: 9(1)

Published: Jan. 30, 2023

Abstract A bidirectional in vitro brain–computer interface (BCI) directly connects isolated brain cells with the surrounding environment, reads neural signals and inputs modulatory instructions. As a noninvasive BCI, it has clear advantages understanding exploiting advanced function due to simplified structure high controllability of ex vivo networks. However, core BCIs, microelectrode arrays (MEAs), urgently need improvements strength signal detection, precision modulation biocompatibility. Notably, nanomaterial-based MEAs cater all requirements by converging multilevel simultaneously applying stimuli at an excellent spatiotemporal resolution, as well supporting long-term cultivation neurons. This is enabled advantageous electrochemical characteristics nanomaterials, such their active atomic reactivity outstanding charge conduction efficiency, improving performance MEAs. Here, we review fabrication applied BCIs from interdisciplinary perspective. We also consider decoding coding activity through highlight various usages coupled dissociated cultures benefit future developments BCIs.

Language: Английский

Citations

29
Interface‐Engineered Field‐Effect Transistor Electronic Devices for Biosensing DOI
Yun Zhang, Duo Chen, He Wang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 4, 2023

Promising advances in molecular medicine have promoted the urgent requirement for reliable and sensitive diagnostic tools. Electronic biosensing devices based on field-effect transistors (FETs) exhibit a wide range of benefits, including rapid label-free detection, high sensitivity, easy operation, capability integration, possessing significant potential application disease screening health monitoring. In this perspective, tremendous efforts achievements development high-performance FET biosensors past decade are summarized, with emphasis interface engineering FET-based electrical platforms biomolecule identification. First, an overview strategies modulation recognition element design is discussed detail. For further step, applications vitro detection real-time monitoring biological systems comprehensively reviewed. Finally, key opportunities challenges electronic discussed. It anticipated that comprehensive understanding will inspire additional techniques developing highly sensitive, specific, stable as well emerging designs next-generation electronics.

Language: Английский

Citations

25
A Highly Conductive n-Type Conjugated Polymer Synthesized in Water DOI Creative Commons
Qifan Li, Jun‐Da Huang, Tiefeng Liu

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(23), P. 15860 - 15868

Published: May 30, 2024

Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is a benchmark hole-transporting (p-type) polymer that finds applications in diverse electronic devices. Most of its success due to facile synthesis water, exceptional processability from aqueous solutions, and outstanding electrical performance ambient. Applications fields like (opto-)electronics, bioelectronics, energy harvesting/storage devices often necessitate the complementary use both p-type n-type (electron-transporting) materials. However, availability materials amenable water-based polymerization processing remains limited. Herein, we present novel method enabling direct yielding highly conductive, water-processable conjugated polymer, namely, poly[(2,2′-(2,5-dihydroxy-1,4-phenylene)diacetic acid)-stat-3,7-dihydrobenzo[1,2-b:4,5-b′]difuran-2,6-dione] (PDADF), with remarkable conductivity as high 66 S cm–1, ranking among highest for polymers processed using green solvents. The new PDADF also exhibits stability, maintaining 90% initial after 146 days storage air. Our synthetic approach, along it yields, promises significant advancements sustainable development organic

Language: Английский

Citations

14