Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 187, P. 183 - 198
Published: Sept. 1, 2024
Language: Английский
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: March 26, 2024
Abstract Despite orientationally variant tears of the meniscus, suture repair is current clinical gold treatment. However, inaccessible in company with re-tears susceptibility remain unresolved. To extend meniscal tools from perspective adhesion and regeneration, we design a dual functional biologic-released bioadhesive (S-PIL10) comprised methacrylated silk fibroin crosslinked phenylboronic acid-ionic liquid loading growth factor TGF-β1, which integrates chemo-mechanical restoration inner regeneration. Supramolecular interactions β-sheets hydrogen bonds richened by (PIL) result enhanced wet adhesion, swelling resistance, anti-fatigue capabilities, compared to neat gel. Besides, elimination reactive oxygen species (ROS) S-PIL10 further fortifies localized meniscus tear affecting inflammatory microenvironment dynamic borate ester bonds, continuously releases TGF-β1 for cell recruitment bridging defect edge. In vivo rabbit models functionally evidence seamless dense reconstruction torn verifying that concept adhesive feasible providing promising revolutionary strategy preclinical research tears.
Language: Английский
Citations
55
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)
Published: June 14, 2024
Abstract Uncontrolled bleeding and wound infections following severe trauma pose significant challenges for existing tissue adhesives, primarily due to their weak wet adhesion, slow adhesion formation, cytotoxicity concerns, lack of antibacterial properties. Herein, an injectable hydrogel (denoted as ES gel) with rapid, robust adhesive sealing inherent activity based on ε‐polylysine a poly(ethylene glycol) derivative is developed. The engineered exhibits rapid gelation behavior, high mechanical strength, strong various tissues, can sustain ultrahigh burst pressure 450 mmHg. It also presents excellent biocompatibility, biodegradability, properties, on‐demand removability. Significantly improved hemostatic efficacy gel compared fibrin glue demonstrated using injury models in rats rabbits. Remarkably, the effectively halt lethal non‐compressible hemorrhages visceral organs (liver, spleen, heart) femoral artery fully anticoagulated pigs. Furthermore, outperforms commercial products sutureless closure repair rat liver defect, skin incision, infected full‐thickness models. Overall, this study highlights promising clinical applications managing uncontrolled hemorrhage, closure, repair.
Language: Английский
Citations
47
Bioactive Materials, Journal Year: 2024, Volume and Issue: 37, P. 106 - 118
Published: March 19, 2024
Effective control of post-extraction hemorrhage and alveolar bone resorption is critical for successful extraction socket treatment, which remains an unmet clinical challenge. Herein, injectable Tetra-PEG hydrogel that possesses rapid gelation, firm tissue adhesion, high mechanical strength, suitable degradability, excellent biocompatibility developed as a sutureless coagulation-independent bioadhesive the management sockets. Our results demonstrate robust adhesive sealing by can provide reliable protection underlying wound stabilize blood clots to facilitate healing.
Language: Английский
Citations
19
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Abstract Injectable shape‐memory materials represent a promising solution for managing severe bleeding from deep, inaccessible wounds. However, many existing expandable hemostats consist of randomly porous networks and often exhibit inadequate liquid absorption, non‐degradability, potential cytotoxicity, which limits their effectiveness in hemostasis wound repair. To overcome these challenges, this study introduces an anisotropic hemostatic cryogel, SALC, featuring oriented macroporous channels made biocompatible polymers (poly(ethylene glycol), gelatin, lignin) through simple one‐step cryo‐structuration process. This structural alignment provides the cryogel with low water flow resistance, efficient fluid transport, rapid shape recovery. SALC demonstrates superior adsorption retention, vitro tamponade sealing, pro‐coagulant properties compared to commercial gelatin sponges XSTAT, along favorable biocompatibility biodegradability. The efficacy surpasses clinically used counterparts rat models liver perforation femoral artery transection. Remarkably, achieves effective porcine hepatic, artery, cardiac injuries. Additionally, supports tissue regeneration by promoting cell migration angiogenesis while mitigating inflammatory responses. is also lightweight easy carry implement. Overall, shows clinical applications treating hemorrhages improving healing.
Language: Английский
Citations
3
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: April 25, 2024
Abstract Soft bioelectronic devices exhibit motion-adaptive properties for neural interfaces to investigate complex circuits. Here, we develop a fabrication approach through the control of metamorphic polymers’ amorphous-crystalline transition miniaturize and integrate multiple components into hydrogel bioelectronics. We attain an about 80% diameter reduction in chemically cross-linked polyvinyl alcohol fibers fully hydrated state. This strategy allows regulation properties, including refractive index (1.37-1.40 at 480 nm), light transmission (>96%), stretchability (139-169%), bending stiffness (4.6 ± 1.4 N/m), elastic modulus (2.8-9.3 MPa). To exploit applications, apply step-index optical probes mouse ventral tegmental area, coupled with fiber photometry recordings social behavioral assays. Additionally, fabricate carbon nanotubes-PVA microelectrodes by incorporating conductive nanomaterials spontaneous activities recording. enable simultaneous optogenetic stimulation electrophysiological light-triggered Channelrhodopsin-2 transgenic mice.
Language: Английский
Citations
15
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 492, P. 152290 - 152290
Published: May 16, 2024
Language: Английский
Citations
11
BMEMat, Journal Year: 2024, Volume and Issue: unknown
Published: May 24, 2024
Abstract With high biocompatibility and degradability, polysaccharide‐based hydrogels are favorable healthcare materials. However, in many biomedical applications, these materials inconvenient to handle with fixed morphology, unable closely match the wounds, easy detach due insufficient adhesion. Inspired by superior wet adhesive properties of marine mussels, researchers have used mussel‐inspired chemistry create mussel‐mimetic injectable that simple operate, controllable shape, highly adhesive, significantly extended their applications such as tissue adhesives, delivery vehicles, engineering scaffolds, wearable sensors. there few comprehensive reviews on both adhesion injectability, critical analyses hydrogels' preparation methods applications. This review fills this gap systematically summarizes strategies for novel hydrogels, including modifying polysaccharides catechol‐ or pyrogallol‐containing small molecules leveraging different interactions between catechol‐/pyrogallol‐modified other substances form crosslinked hydrogels. Furthermore, recent discussed, future challenges research trends proposed.
Language: Английский
Citations
11
Small, Journal Year: 2024, Volume and Issue: 20(33)
Published: April 21, 2024
Abstract The quest for efficient hemostatic agents in emergency medicine is critical, particularly managing massive hemorrhages dynamic and high‐pressure wound environments. Traditional self‐gelling powders, while beneficial due to their ease of application rapid action, fall short such challenging conditions. To bridge this gap, the research introduces a novel powder that combines ultrafast covalent gelation robust wet adhesion, presenting significant advancement acute hemorrhage control. This ternary system comprises ε ‐polylysine ( ‐PLL) 4‐arm polyethylene glycol succinyl succinate (4‐arm‐PEG‐NHS) forming hydrogel framework. Na 2 HPO 4 functions as “H + sucker” expedite amidation reaction, slashing time under 10 s, crucial immediate blood loss restriction. Moreover, PEG chains' hydrophilicity facilitates absorption interfacial blood, increasing generated hydrogel's cross‐linking density strengthens its tissue bonding, thereby resulting excellent mechanical adhesion properties. In vitro experiments reveal optimized formulation's exceptional compliance, procoagulant activity, biocompatibility antibacterial efficacy. porcine models heart injuries arterial punctures, it outperforms commercial agent Celox, confirming effective hemostasis. Conclusively, study presents transformative approach hemostasis, offering reliable potent solution management hemorrhage.
Language: Английский
Citations
10
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract Open wounds damage the integrity of injured tissues and expose them to bacterial infections. Traditional suturing often lead reinjuring damaged tissues. This delays healing process, especially in presence a infection. A Janus hydrogel adhesive with bio‐adhesion multi‐mode disinfection (BAMD) capabilities (a BAMD hydrogel) is developed using spin‐coating which can serve as an alternative traditional sutures. The organic–inorganic hybrid combination Chinese‐medicine organic small molecule rhein (Rhe) graphene oxide (GO) endows dual‐mode antibacterial activity driven by photodynamic (PD) photothermal (PT) effects including short‐term rapid (15‐min irradiation, 99.95% bactericidal rate) long‐term action absence light (100% rate after 6 h dark incubation). vivo results demonstrated 97.25% against MRSA. Throughout wound recovery effectively reduced inflammation promoted tissue healing. versatile strategy offers new insights into preventing postoperative adhesion sealing repairing large‐scale damage.
Language: Английский
Citations
2
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 285 - 302
Published: Jan. 13, 2025
Language: Английский
Citations
2